Efficacy of olive leaf extract–containing cream for facial rejuvenation: A pilot study

Abstract

Background Olive leaf extract (OLE), a naturally extracted product from olive leaves, contains oleuropein and other bioactive phenolic compounds. Oleuropein was identified to have various medical properties. It was also found to inhibit the effects of both acute and chronic UVB‐induced skin damage as well as accelerate wound healing activity. Aims To evaluate the efficacy of olive leaf extract–containing cream on facial rejuvenation. Methods This is a prospective pilot study with a total of 36 participants, who presented with photoaging skin. All participants applied the olive leaf extract–containing cream (SUPERHEAL™ O‐Live Cream, PhytoCeuticals, Inc, USA) to their whole face twice daily for 2 months. Primary outcomes measured in the study were the changes in the biophysical properties of the skin assessed with the following parameters: melanin and erythema index, transepidermal water loss (TEWL), skin hydration, skin pH, sebum level, texture, and wrinkles. Results After 2 months, TEWL decreased significantly (P = .007) and maintained the results 1 month after discontinuation of the treatment (P = .007). Skin hydration also increased significantly after 2 months (P = .004). Wrinkles improved significantly on all follow‐ups (P < .001, P = .001, P = .001, respectively). An image of the skin captured using Visioscan® showed improvement of the skin texture 2 months after treatment. Majority of the participants (64%) noted improvement in their skin texture. Conclusion Olive leaf extract–containing cream provided benefits on skin rejuvenation in human skin.

A Novel Pro-Melanogenic Effect of Standardized Dry Olive Leaf Extract on Primary Human Melanocytes from Lightly Pigmented and Moderately Pigmented Skin

“…Moreover, several previous studies have demonstrated the beneficial effects of DOLE, which, along with its aqueous solubility, provides an attractive candidate for further evaluation for the treatment of skin pigmentary disorders. A previous clinical study [38] showed that the application of a patented OLE-containing cream (SuperHeal™ O-Live Cream, PhytoCeuticals, Inc., Elmwood Park, NJ, USA) for two months led to facial rejuvenation; the authors attributed the effects to the photoprotective, antioxidant, and anti-inflammatory properties of OLE in the formulation. Although the melanin index was not changed from the baseline group, the authors further reported that 53% of the 36 study participants showed visual reduction in hyperpigmented facial spots.…”

Biological effects of the olive tree and its derivatives on the skin

“…47 In terms of adverse effects, no cases of toxicity were reported, probably due to the fact that these products are not able to reach the dermal venous circulation. 48 In the same vein, Wanitphakdeedecha et al 49 described that the use of a facial cream enriched with olive leaf extract promotes facial rejuvenation by decreasing transepidermal water loss and wrinkles and improving hydration.…”

“…In vivo: prospective pilot study with humans (women and men): after two months of applying the cream twice daily, transepidermal water loss was reduced, skin hydration was increased, wrinkles and skin texture improved. 49…”

Potential therapeutic of olive oil industry by‐products in skin health: a review

“…Moreover, this effect was correlated to the decrease of cutaneous inflammation and the antioxidant activity of olive phenolic compounds like HTyr. Wanitphakdeedecha et al (2020) conducted a study where SUPERHEAL TM O-Live Cream was applied twice daily for 2 months in thirty-six female volunteers. The reported results showed that the transepidermal water loss (TEWL) started to decrease and the skin hydration started to significantly increase 2 months after the beginning of the treatment.…”