Efficacy of octreotide but not long‐acting somatostatin analogue for severe refractory diabetic diarrhoea

Corbould, A.; Campbell, J.

doi:10.1111/j.1464-5491.2009.02766.x

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…Tricyclic antidepressants may be beneficial because of their anticholinergic properties. Case reports have supported the efficacy of somatostatin analogs in otherwise refractory, apparently secretory, diarrhea in patients with autonomic neuropathy (84). Clonidine, an a-2-adrenergic RA is effective in the treatment of refractory diarrhea (85), but patients must be monitored for hypotension, especially when dehydrated.…”

Section: Managementmentioning

confidence: 99%

Gastrointestinal Symptoms in Diabetes: Prevalence, Assessment, Pathogenesis, and Management

et al. 2018

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If you haven't measured something, you really don't know much about it.-Karl Pearson (attributed)Gastrointestinal (GI) symptoms represent an important and often unappreciated cause of morbidity in diabetes, although the significance of this burden across the spectrum of patients and the underlying pathophysiology, including the relationship of symptoms with glycemic control, remain poorly defined. The relevance of GI symptoms and the necessity for their accurate assessment have increased with the greater focus on the gut as a therapeutic target for glucose lowering. This review addresses the prevalence, assessment, pathogenesis, and management of GI symptoms in diabetes, beginning with broad principles and then focusing on specific segments of the GI tract. We initially performed a literature search of PubMed by using synonyms and combinations of the following search terms: "gastrointestinal symptoms", "diabetes", "prevalence", "pathogenesis", "diagnosis", and "management". We restricted the search results to English only. Review papers and meta-analyses are presented as the highest level of evidence where possible followed by randomized controlled trials, uncontrolled trials, retrospective and observational data, and expert opinion.

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Section: Managementmentioning

confidence: 99%

Gastrointestinal Symptoms in Diabetes: Prevalence, Assessment, Pathogenesis, and Management

et al. 2018

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“…Трициклічні антидепресанти можуть бути корисними через антихолінергічні властивості. Клінічні випадки підтвердили ефективність аналогів соматостатину у разі рефрактерної секреторної діареї у пацієнтів з вегетативною нейропатією [43]. Клонідин, α 2 -адренергічний агоніст рецепторів, ефективний при лікуванні рефрактерної діареї, але слід контролювати вияви гіпотонії, особливо при явищах зневоднення [44].…”

Section: ураження кишечникаunclassified

Gastrointestinal tract disorders in diabetes mellitus

Tkach¹,

Chichula²

2020

CE&ES

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“…Loperamide and codeine are used but neither is recommended for long‐term treatment and they may not be very effective. Both octreotide and lanreotide have been tried to treat the autonomic component …”

Section: ‘Diabetic Diarrhoea’mentioning

confidence: 99%

Diarrhoea and diabetes

Hillson¹

2018

Practical Diabetes

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Efficacy of octreotide but not long‐acting somatostatin analogue for severe refractory diabetic diarrhoea

Cited by 9 publications

References 11 publications

Gastrointestinal Symptoms in Diabetes: Prevalence, Assessment, Pathogenesis, and Management

Gastrointestinal Symptoms in Diabetes: Prevalence, Assessment, Pathogenesis, and Management

Gastrointestinal tract disorders in diabetes mellitus

Diarrhoea and diabetes

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