No abstract

Androgen receptor blocking agents have an established role in the treatment of disseminated prostate carcinoma. However, combined androgen blockade in elderly men with disseminated prostate carcinoma results in high bone turnover with significant cancellous bone loss. The results of this study show that adjuvant therapy with intermittent cyclic etidronate may prevent these changes and decrease the risk of spinal fractures.

Antenatal clinical factors were modestly predictive of return for testing and abnormal glucose tolerance post-pregnancy in women with GDM. Risk score calculations were ineffective in predicting outcomes: risk scores developed in other populations require validation. Ongoing glucose screening is indicated for all women with GDM.

In women with GDM, fasting glucose on OGTT predicted response to metformin: at fasting glucose ≤5.2 mmol/L, the probability of response was 93%. Antenatal clinics should determine locally relevant predictors of response to metformin in women with GDM.

The impact of personal construct and psychodynamic group work on the psychosocial functioning of offender adolescents was evaluated. The repeated measures design involved 3 data collections. Data from 102 participants included measures of 5 pairs of maturational processes and 5 psychological states. Group work was effective immediately after terminating treatment in increasing helpful maturational processes and in reducing the less helpful maturational processes. The group work was also effective to some extent in reducing less helpful psychological states. The implications of this research for future interventions and its evaluation are discussed.