Efficacy of Non-heme Iron Fortified Diets: A Review

Salim-ur-Rehman, .; Huma, Nuzhat; Tarar, Omer Mukhtar; Shah, Wajid Ali

doi:10.1080/10408390802304206

Cited by 18 publications

(4 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Micronutrient malnutrition, particularly deficiencies in Fe and Zn, afflicts over three billion people worldwide, resulting in overall poor heath, anemia, increased morbidity and mortality rates, and reduced worker productivity (Bouis 2007, Peleg et al 2008, Salim-Ur-Rehman et al 2010, Welch and Graham 2004. It is a particular problem in developing countries, where most people rely on cereals as their staple food.…”

Section: Introductionmentioning

confidence: 99%

Wheat-Aegilops chromosome addition lines showing high iron and zinc contents in grains

et al. 2011

View full text Add to dashboard Cite

Deficiencies of iron (Fe) and zinc (Zn) in afflict over three billion people worldwide, and deficiencies of these minerals in soil also limit crop production in one-third (Fe) and nearly half (Zn) of the world's total cereal growing area. Screening genetic resources for improving wheat grain Fe and Zn contents and efficiency can contribute to both human health and crop production. We evaluated 47 wheat-Aegilops disomic addition lines derived from 6 Aegilops species to identify the chromosomes carrying genes for high grain Fe and Zn concentrations. Addition lines with chromosomes 1S l and 2S l of Ae. longissima, 1S S and 2S S of Ae. searsii, 2U and 6U of Ae. umbellulata, B of Ae. caudata, 4S v of Ae. peregrina, and 5 M g of Ae. geniculata showed increased grain Fe or Zn concentration of between 50% and 248% compared with the recipient cultivar, Chinese Spring. Most of alien chromosomes addition lines with significantly higher grain Fe and/or Zn concentrations belonged to the U and S genotypes and homoeologous groups 1 and 2 chromosomes. These lines could be used for the precise introgression of genes into elite wheat cultivars to improve wheat micronutrient concentrations.

show abstract

Section: Introductionmentioning

confidence: 99%

Wheat-Aegilops chromosome addition lines showing high iron and zinc contents in grains

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The ability of hemoglobin hydrolysate to promote absorption of non-heme iron may be attributed to the special amino acids and peptides produced from hemoglobin hydrolysis. The poor absorption efficiency of non-heme iron in vivo is due to its low solubility [36]. The carboxyl, hydroxyl and amino groups of amino acids and peptides increase the solubility of non-heme iron in combination with it [18,37].…”

Section: Discussionmentioning

confidence: 99%

The efficiency and safety evaluation of hemoglobin hydrolysate as a non-heme iron fortifier

Xue¹,

Jiang²,

Zhang³

et al. 2024

Food Science and Human Wellness

View full text Add to dashboard Cite

Hemoglobin hydrolysate is derived from the enzymatic degradation of hemoglobin. This work aimed to evaluate whether hemoglobin hydrolysate promotes the absorption of non-heme iron and the safety of absorbed iron in mice by analyzing the iron binding content, iron circulation, and liver homeostasis. We found that hemoglobin hydrolysate promoted the absorption of non-heme iron with high efficiency in duodenum by spontaneously binding non-heme iron during digestion, and increased hepatic iron content by up-regulating divalent metal transporter 1 (DMT1), zinc transporter 14 (ZIP14), but hepatic iron content only increased at 3 weeks. Duodenal iron entered the blood through ferroportin without restriction at 3 weeks, and excessive iron entered the liver and then affected the hepatocyte membranes permeability and lipid synthesis through oxidative stress. With the prolongation of dietary intervention, the up-regulated hepcidin acted on the ferroportin to restrict excess iron from entering the blood, and then the hepatic homeostasis recovered. In addition, hemoglobin hydrolysate enhanced the hepatic antioxidant capacity. Taken together, hemoglobin hydrolysate has a strong ability to promote the absorption of non-heme iron in vivo, and the absorbed iron is relatively safe due to the regulation of hepcidin.

show abstract

“…Micronutrient malnutrition, particularly deficiencies in Fe and Zn, affects over three billion people in the world (Salim- Ur-Rehman et al, 2010;Wang et al, 2011;Welch and Graham, 2004). Iron is an important component in human diets since it regulates enzyme activity and plays a role in the immune system (Lynch, 2003); it is an important component of human blood (Tuman and Doisy, 1978).…”

mentioning

confidence: 99%

Diversity of Iron and Zinc Content in Bananas from East and Central Africa

Pillay¹,

Fungo²

2016

horts

View full text Add to dashboard Cite

Bananas and plantains (Musa sp.) are major staple foods in many developing countries of the world. Although bananas are rich in carbohydrate, fiber, protein, fat, and vitamins A, C, and B6 they are largely deficient of iron (Fe), iodine, and zinc (Zn). A small increase in the micronutrient content of bananas could play a major role in combating disorders that are due to deficiency of mineral micronutrients such as Fe and Zn. The objective of this study was to determine the Fe and Zn content of 47 banana genotypes from a germplasm collection in Uganda using atomic absorption spectrophotometry. The Fe and Zn content showed wide variability and highly significant differences (P < 0.001) within and among the different banana categories selected for this study. The highest average Fe content (1.42 mg/100 g) was found in ‘Saba’ (ABB) while the least Fe content (0.06 mg/100 g) was found in ‘Kikundi’ (AAA). The highest average Zn content (1.21 mg/100 g) among the analyzed accessions was found in ‘Kivuvu’ (ABB) while Zn was not detectable in both ‘Kabucuragye’ (AAA) and ‘Grand Naine’ (AAA). Considering these figures, there is a greater than 20-fold variation in the Fe and Zn levels of the banana genotypes used this study suggesting that genetic improvement of genotypes for enhanced micronutrient levels may be achieved by breeding.

show abstract

Efficacy of Non-heme Iron Fortified Diets: A Review

Cited by 18 publications

References 79 publications

Wheat-Aegilops chromosome addition lines showing high iron and zinc contents in grains

Wheat-Aegilops chromosome addition lines showing high iron and zinc contents in grains

The efficiency and safety evaluation of hemoglobin hydrolysate as a non-heme iron fortifier

Diversity of Iron and Zinc Content in Bananas from East and Central Africa

Contact Info

Product

Resources

About