Efficacy of Neuromodulation Interventions for the Treatment of Sexual Dysfunction: A Systematic Review

Jin, Max Y.; D’Souza, Ryan S; Abd‐Elsayed, Alaa

doi:10.1016/j.neurom.2022.07.004

Cited by 6 publications

(5 citation statements)

References 65 publications

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“…Despite the advantages of noninvasive neuromodulation techniques over drug control and invasive methods, significant problems persist in their clinical application. These mainly include the following: (1). The high attenuation of the skull makes it difficult to regulate the intensity of the stimulating signals when they reach the target points, and high-intensity signals can easily burn skin tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Neurological diseases are characterized by dysfunction in the nervous system, whereas mental health disorders mainly encompass cognitive, emotional, willpower, and behavioral disorders (clinical manifestations) caused by brain dysfunction. These diseases often lack a clear pathogenic focus and only manifest as neurological dysfunctions [ 1 ], making treatment difficult. Simultaneously, a large number of patients has these diseases.…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review

et al. 2023

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We review the research progress on noninvasive neural regulatory systems through system design and theoretical guidance. We provide an overview of the development history of noninvasive neuromodulation technology, focusing on system design. We also discuss typical cases of neuromodulation that use modern noninvasive electrical stimulation and the main limitations associated with this technology. In addition, we propose a closed-loop system design solution of the “time domain”, “space domain”, and “multi-electrode combination”. For theoretical guidance, this paper provides an overview of the “digital brain” development process used for noninvasive electrical-stimulation-targeted modeling and the development of “digital human” programs in various countries. We also summarize the core problems of the existing “digital brain” used for noninvasive electrical-stimulation-targeted modeling according to the existing achievements and propose segmenting the tissue. For this, the tissue parameters of a multimodal image obtained from a fresh cadaver were considered as an index. The digital projection of the multimodal image of the brain of a living individual was implemented, following which the segmented tissues could be reconstructed to obtain a “digital twin brain” model with personalized tissue structure differences. The “closed-loop system” and “personalized digital twin brain” not only enable the noninvasive electrical stimulation of neuromodulation to achieve the visualization of the results and adaptive regulation of the stimulation parameters but also enable the system to have individual differences and more accurate stimulation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review

et al. 2023

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“…The local tissue inflammation factors as shown in chronic pain conditions can lead to central changes in pain perception. Peripheral nerve stimulation systems may be directly inhibiting local neurotransmitters and endorphins that are linked to chronic pain and may work in conjunction with the gating theory [ 11 , 12 ]. It is suggested that peripheral nerve stimulation systems can have central neuroplastic effects to change pain states and this may explain the continued pain relief that is experienced by patients following peripheral nerve stimulation lead removal.…”

Section: Proposed Mechanism Of Action For Peripheral Nerve Stimulationmentioning

confidence: 99%

Peripheral Nerve Stimulation in Painful Conditions of the Upper Extremity—An Overview

et al. 2022

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Our objective is to present a brief history of the evolution of peripheral nerve stimulation, the current understanding of peripheral nerve stimulation mechanisms in chronic pain, peripheral nerve stimulation applications in upper extremity chronic pain conditions, and complications of peripheral nerve stimulation. The evolution of peripheral nerve stimulation from the early ages to the current status has been facilitated by discoveries in neurobehavioral mechanisms of pain, advances in technology and percutaneous lead development, and the availability of high-quality portable ultrasound units. Peripheral nerve stimulation application in managing upper extremity pain of amputated limbs, post-stroke shoulder pain, complex regional pain syndrome (CRPS), and median, ulnar, and radial neuropathies are discussed. Finally, we describe complications of peripheral nerve stimulation. The availability of ultrasound-guided peripheral nerve stimulation techniques and superior peripheral nerve stimulation technology have opened up new and minimally invasive treatment options for chronic intractable neuropathic pain of the upper extremity. Additionally, the ability to place peripheral nerve stimulation leads percutaneously without open peripheral nerve surgery expands the pool of implanting physicians, while simultaneously decreasing the risks and complications that are associated with open surgery.

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“…Specific symptoms treated by neuromodulation include pain associated with disease or trauma, urological conditions, and other functional disorders [ 24 ]. Common questionnaires to assess these symptoms include the Visual Analogue Scale (VAS) and the Numeric Rating Scale (NRS) for pain, and the Short-Form Health Survey (SF-36) for physical function.…”

Section: Introductionmentioning

confidence: 99%

Neuromodulation for Peripheral Nerve Regeneration: Systematic Review of Mechanisms and In Vivo Highlights

et al. 2023

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While denervation can occur with aging, peripheral nerve injuries are debilitating and often leads to a loss of function and neuropathic pain. Although injured peripheral nerves can regenerate and reinnervate their targets, this process is slow and directionless. There is some evidence supporting the use of neuromodulation to enhance the regeneration of peripheral nerves. This systematic review reported on the underlying mechanisms that allow neuromodulation to aid peripheral nerve regeneration and highlighted important in vivo studies that demonstrate its efficacy. Studies were identified from PubMed (inception through September 2022) and the results were synthesized qualitatively. Included studies were required to contain content related to peripheral nerve regeneration and some form of neuromodulation. Studies reporting in vivo highlights were subject to a risk of bias assessment using the Cochrane Risk of Bias tool. The results of 52 studies indicate that neuromodulation enhances natural peripheral nerve regeneration processes, but still requires other interventions (e.g., conduits) to control the direction of reinnervation. Additional human studies are warranted to verify the applicability of animal studies and to determine how neuromodulation can be optimized for the greatest functional restoration.

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Efficacy of Neuromodulation Interventions for the Treatment of Sexual Dysfunction: A Systematic Review

Cited by 6 publications

References 65 publications

Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review

Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review

Peripheral Nerve Stimulation in Painful Conditions of the Upper Extremity—An Overview

Neuromodulation for Peripheral Nerve Regeneration: Systematic Review of Mechanisms and In Vivo Highlights

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