Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas: 10 year single-center experience and literature review

Teran, Dolores Ayllon; Beltran, Oscar; Bru, Rubén Ciria; González, Elena Mateos; Rosa, M.J. Peña; Molina, A.; Cillero, Pedro López; Delgado, Javier Briceño

doi:10.3748/wjg.v20.i29.10137

Cited by 14 publications

(7 citation statements)

References 22 publications

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“…Radiology plays a significant role in defining important tumor features which affect prognosis and resectability, including caudate lobe invasion, extrahepatic abdominal disease, and portal vein involvement [62]. Most research points to combination therapy consisting of chemotherapy, resection, and liver transplant to provide the best prognosis, with pre-operative cisplatin and doxorubicin improving resection rates from 30% to 87% [63], and 5 year survival after transplant of 82.6% [64].…”

Section: Hepatoblastomamentioning

confidence: 99%

Rare primary hepatic malignancies: A case-based review

McArthur

Allen

et al. 2021

Clinical Imaging

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Section: Hepatoblastomamentioning

confidence: 99%

Rare primary hepatic malignancies: A case-based review

McArthur

Allen

et al. 2021

Clinical Imaging

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“…In particular, late effects of treatment, such as renal insufficiency, tissue hypoplasia, and bone deformities [12], lead to lifelong limitations in daily life and represent a high level of suffering. Survival rates have improved from 20 to 80-90 percent in recent decades [13][14][15] due to excellent research in diagnostics [16,17] and therapy [18,19]. Nevertheless, it is important to survey the HRQoL and mental health of affected persons to explore a possible gap in healthcare.…”

Section: Introductionmentioning

confidence: 99%

Health-Related Quality of Life and Mental Health of Children with Embryonal Abdominal Tumors

Behrendt,

Boettcher,

Zierke

et al. 2023

Children

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(1) Background: Embryonal abdominal tumors are one of the most common entities of solid childhood cancer. The present study investigates the Health-Related Quality of Life (HRQoL) and the mental health of children to obtain a comprehensive picture of their health status and uncover a possible gap in healthcare. (2) Methods: The sample consisted of 54 children who were treated for embryonal abdominal tumors and a control group of 46 children who received uncomplicated outpatient surgery. The HRQoL and the mental health were assessed by the parent proxy reports of the questionnaires Pediatric Quality of Life Inventory (PedsQL) and Strengths and Difficulties Questionnaire (SDQ). (3) Results: Children with embryonal abdominal tumors showed significantly lower HRQoL and mental health values compared to the norm data. The index group showed lower values in the social subscales of HRQoL and mental health compared to the control group. (4) Conclusions: Embryonal abdominal tumors affect the well-being of children. There is still a gap in healthcare due to children’s HRQoL and mental health, especially regarding social development. It is essential to further advance the psychological care of children and improve their chances to develop social relationships.

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“…As a rare cancer with an incidence of only 1.2–1.5/1000,000 in children, hepatoblastoma (HB) is usually diagnosed in children aged under 3 years [ 1 ]. However, HB is the most common malignant tumor in hepatic cancer in children, accounting for 60% of the primary hepatic cancer in children [ 2 , 3 ]. With the continuous improvement in modern medical technology, the disease-free survival rate in low-risk children with HB can reach 80–90% [ 4 ]; however, the prognosis in high-risk pediatric patients, especially those with distant metastasis, remains poor.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and prognostic factors of hepatoblastoma in 316 children aged under 3 years – a 14-year retrospective single-center study

Zhi

Zhang

et al. 2021

BMC Pediatr

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Background The aim of the present study was to summarize the clinical characteristics of in children aged under 3 years and analyze the related factors affecting the prognosis. Methods The clinical data of 316 children aged under 3 years (192 males and 124 females) who were admitted to Beijing Tongren Hospital with a pathological diagnosis of HB between May 2005 and May 2019 were analyzed retrospectively. The factors influencing the therapeutic effects on and survival of HB in children with HB were analyzed. Results (1) The median age of the enrolled patients was 1.45 years. The most common initial symptom was an abdominal mass (69.0%). The average serum alpha-fetoprotein (AFP) level and platelet count at the initial visit were (97,406.5 ± 5022.8) ng/mL and (418 ± 206) × 109/L, respectively. The epithelial type was the main pathological type (51.9%). According to the PRETEXT preoperative typing system, the most common stage was stage III (57.0%), whereas according to the postoperative Evans staging system, the most common stage was stage IV (41.8%). At the initial visit, 62 cases (19.6%) had vascular invasion, 52 cases (16.5%) had extrahepatic tumor extension, and 20 cases (6.3%) had tumor rupture. Distant metastasis occurred in 132 cases, and the most common metastatic site was the lung (80.3%). The incidence in East China was relatively high (35.4%). (2) The children were followed up until May 2020 (the median follow-up duration was 62 months). It was found that 194 patients had complete remission and 62 had partial remission. The Kaplan–Meier survival analysis showed that the overall survival was 95.3, 88.2, and 79.8% at 1 year, 3 years, and 5 years, respectively, and the event-free survival was 91.1, 83.2, and 75.1%, respectively. The Cox regression analysis showed that AFP level, platelet count, PRETEXT IV, vascular invasion, and distant metastasis at the initial visit were independent risk factors for the prognosis of children with HB (p < 0.05 in all). Conclusion The prognosis of HB was correlated with the AFP level, platelet count, PRETEXT staging, vascular invasion, and distant metastasis at initial diagnosis.

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Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas: 10 year single-center experience and literature review

Abstract: Our series shows how multimodal management of Hbl, exhaustive control and a meticulous surgical approach leads to almost 100% complete resection with optimal postoperative results.

Cited by 14 publications

References 22 publications

Rare primary hepatic malignancies: A case-based review

Rare primary hepatic malignancies: A case-based review

Health-Related Quality of Life and Mental Health of Children with Embryonal Abdominal Tumors

Clinical characteristics and prognostic factors of hepatoblastoma in 316 children aged under 3 years – a 14-year retrospective single-center study

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