Efficacy of natural antimicrobials derived from phenolic compounds in the control of biofilm in children and adolescents compared to synthetic antimicrobials: A systematic review and meta-analysis

Martins, Mariana Leonel; Ribeiro-Lages, Mariana Batista; Ferreira, Daniele Masterson Tavares Pereira; Magno, Marcela Baraúno; Cavalcanti, Yuri Wanderley; Maia, Lucianne Cople; Fonseca‐Gonçalves, Andréa

doi:10.1016/j.archoralbio.2020.104844

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Biochemical tests included hydrogen sulphide, Indole, Methyl-red, Voges Proskauer, urea, motility, oxidase, and catalase tests. Incubation was at 37˚C for 24 hours [20].…”

Section: Identification Biofilm Positive Bacteriamentioning

confidence: 99%

Antimicrobial Activities of Extracts of <i>Macrosphyra longistyla</i> against Gram-Positive Oral Biofilm-Formers from School Children in Southwestern Nigeria and Toxicity Studies Using Brine Shrimps

Nwankwo,

Folarin,

Osho

2024

AiM

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The world will benefit from more effective antimicrobial agents against oral conditions arising from the actions of biofilm forming bacteria. Also, information is lacking on the oral biofilm-forming bacterial diversity in Southwestern Nigeria. In this study, we isolate and characterize oral biofilm producing bacteria in the oral cavities of schoolchildren in Southwestern Nigeria.We also investigate the antimicrobial properties of Macrosphyra longistyla extracts against the biofilm-formers and the toxicity of potent extracts. Samples were obtained from 109 schoolchildren aged 4 -14 years from Lagos, Oyo and Osun States. Agar well diffusion technique was used in the antimicrobial susceptibility testing. Toxicity testing was done using brine shrimps (Artemia salina). Biofilm-formers in this study are Klebsiella sp., Streptococcus sp., Staphylococcus sp., and Micrococcus sp. Ethanol leaf extracts had the highest activity against all biofilm-producing bacteria. Ethanol stem bark extract, which elicited activity against Klebsiella only, was found to be less toxic than the ethanol leaf extract. Staphylococcus showed >10 mm susceptibility to the ethanol and aqueous extracts of Macrosphyra longistyla. Streptococcus and Micrococcus were susceptible to the antimicrobial actions of the ethanolic leaf extracts. Although the ethanol extracts of the leaves had lower minimum inhibitory concentrations than the ethanol extracts of the stem bark, toxicity studies showed ethanol extracts of the stem-bark to be more toxic than the ethanol extracts of the leaves. In conclusion, ethanolic extracts of Macrosphyra longistyla show potential as sources of antimicrobials against gram-positive, oral biofilm-forming bacteria.

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“…Biochemical tests included hydrogen sulphide, Indole, Methyl-red, Voges Proskauer, urea, motility, oxidase, and catalase tests. Incubation was at 37˚C for 24 hours [20].…”

Section: Identification Biofilm Positive Bacteriamentioning

confidence: 99%

Antimicrobial Activities of Extracts of <i>Macrosphyra longistyla</i> against Gram-Positive Oral Biofilm-Formers from School Children in Southwestern Nigeria and Toxicity Studies Using Brine Shrimps

Nwankwo,

Folarin,

Osho

2024

AiM

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“…On the other hand, herbal mouthwashes as antiplaque agents are inferior to the gold standard chlorhexidine mouth wash [ 147 ]. According to a recent systematic review and meta-analysis, there is low to moderate evidence that natural antimicrobials derived from phenolic compounds are as effective as chlorhexidine in reducing oral microorganisms counts but not for controlling dental biofilm [ 148 ]. However, the available clinical trials exhibit a high degree of heterogeneity and risk of biases that limit the justification of using these products [ 149 , 150 ].…”

Section: Novel Antibacterial Agents and Strategies To Overcome Bacterial Resistance In Dental Biofilm: Pros And Consmentioning

confidence: 99%

Classic vs. Novel Antibacterial Approaches for Eradicating Dental Biofilm as Adjunct to Periodontal Debridement: An Evidence-Based Overview

et al. 2021

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Periodontitis is a multifactorial chronic inflammatory disease that affects tooth-supporting soft/hard tissues of the dentition. The dental plaque biofilm is considered as a primary etiological factor in susceptible patients; however, other factors contribute to progression, such as diabetes and smoking. Current management utilizes mechanical biofilm removal as the gold standard of treatment. Antibacterial agents might be indicated in certain conditions as an adjunct to this mechanical approach. However, in view of the growing concern about bacterial resistance, alternative approaches have been investigated. Currently, a range of antimicrobial agents and protocols have been used in clinical management, but these remain largely non-validated. This review aimed to evaluate the efficacy of adjunctive antibiotic use in periodontal management and to compare them to recently suggested alternatives. Evidence from in vitro, observational and clinical trial studies suggests efficacy in the use of adjunctive antimicrobials in patients with grade C periodontitis of young age or where the associated risk factors are inconsistent with the amount of bone loss present. Meanwhile, alternative approaches such as photodynamic therapy, bacteriophage therapy and probiotics showed limited supportive evidence, and more studies are warranted to validate their efficiency.

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Pediatric dentistry systematic reviews using the GRADE approach: methodological study

Alvarenga-Brant,

Notaro,

Stefani

et al. 2024

BMC Oral Health

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Background To assess the reporting of the certainty of the evidence using the GRADE approach in systematic reviews of interventions in pediatric dentistry. Methods The inclusion criteria were systematic reviews of randomized clinical trials (RCTs) and non-randomized studies of interventions (NRSIs) in pediatric dentistry that reported the certainty of the evidence through the GRADE approach. Paired independent reviewers screened the studies, extracted data, and appraised the methodological quality using the Assessing the Methodological Quality of Systematic Reviews (AMSTAR 2) tool. The certainty of the evidence was extracted for each outcome. A descriptive analysis was conducted. Results Around 28% of pediatric dentistry reviews of interventions used the GRADE approach (n = 24). Twenty reviews reported 112 evidence outcomes from RCTs and 13 from NRSIs using GRADE evidence profile tables. The methodological quality was high (16.7%), moderate (12.5%), low (37.5%), and critically low (33.3%), fulfilling the majority of the AMSTAR 2 criteria. The certainty of the evidence for outcomes generated from RCTs and NRSIs was very low (40.2% and 84.6%), low (33.1% and 7.7%), moderate (17.8% and 7.7%), and high (9.8% and 0.0%). The main reasons to downgrade the certainty were due to (for RCTs and NRSIs, respectively): risk of bias (68.8% and 84.6%), imprecision (67.8% and 100.0%), inconsistency (18.8% and 23.1%), indirectness (17.8% and 0.0%), and publication bias (7.1% and 0.0%). Conclusion The proportion of systematic reviews assessing the certainty of the evidence using the GRADE approach was considered small, considering the total initial number of published pediatric dentistry reviews of intervention. The certainty of the evidence was mainly very low and low, and the main problems for downgrading the certainty of evidence were due to risk of bias and imprecision. Registration PROSPERO database #CRD42022365443.

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Efficacy of natural antimicrobials derived from phenolic compounds in the control of biofilm in children and adolescents compared to synthetic antimicrobials: A systematic review and meta-analysis

Cited by 4 publications

References 29 publications

Antimicrobial Activities of Extracts of <i>Macrosphyra longistyla</i> against Gram-Positive Oral Biofilm-Formers from School Children in Southwestern Nigeria and Toxicity Studies Using Brine Shrimps

Antimicrobial Activities of Extracts of <i>Macrosphyra longistyla</i> against Gram-Positive Oral Biofilm-Formers from School Children in Southwestern Nigeria and Toxicity Studies Using Brine Shrimps

Classic vs. Novel Antibacterial Approaches for Eradicating Dental Biofilm as Adjunct to Periodontal Debridement: An Evidence-Based Overview

Pediatric dentistry systematic reviews using the GRADE approach: methodological study

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Efficacy of natural antimicrobials derived from phenolic compounds in the control of biofilm in children and adolescents compared to synthetic antimicrobials: A systematic review and meta-analysis

Cited by 4 publications

References 29 publications

Antimicrobial Activities of Extracts of &lt;i&gt;Macrosphyra longistyla&lt;/i&gt; against Gram-Positive Oral Biofilm-Formers from School Children in Southwestern Nigeria and Toxicity Studies Using Brine Shrimps

Antimicrobial Activities of Extracts of &lt;i&gt;Macrosphyra longistyla&lt;/i&gt; against Gram-Positive Oral Biofilm-Formers from School Children in Southwestern Nigeria and Toxicity Studies Using Brine Shrimps

Classic vs. Novel Antibacterial Approaches for Eradicating Dental Biofilm as Adjunct to Periodontal Debridement: An Evidence-Based Overview

Pediatric dentistry systematic reviews using the GRADE approach: methodological study

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Product

Resources

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Antimicrobial Activities of Extracts of <i>Macrosphyra longistyla</i> against Gram-Positive Oral Biofilm-Formers from School Children in Southwestern Nigeria and Toxicity Studies Using Brine Shrimps

Antimicrobial Activities of Extracts of <i>Macrosphyra longistyla</i> against Gram-Positive Oral Biofilm-Formers from School Children in Southwestern Nigeria and Toxicity Studies Using Brine Shrimps