Efficacy of nanoemulsion with Pterodon emarginatus Vogel oleoresin for topical treatment of cutaneous leishmaniasis

Kawakami, Monique; Zamora, Lisset Ortíz; Araújo, Raquel Silva; Fernandes, Caio P.; Ricotta, Tiago Q.N.; Oliveira, Laser Antônio Machado; Queiroz-Júnior, Celso Martins; Fernandes, Ana Paula; Conceição, Edemilson Cardoso da; Ferreira, Lucas Antônio Miranda; Barros, André Luís Branco de; Aguiar, Marta Gontijo; Oliveira, Anna Eliza Maciel de Faria Mota

doi:10.1016/j.biopha.2020.111109

Cited by 25 publications

(15 citation statements)

References 65 publications

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Section: Future Nanotechnological Therapies For Fungal Infectionmentioning

confidence: 99%

“…NEs can be used as transport tools for systemic antimicrobial (Harun et al, 2018;Karami et al, 2019), topical (Hussain et al, 2020;Santos et al, 2012), oral (Baheti et al, 2015), and intraperitoneal therapies (Al-Otaibi, Alkhatib, & Wali, 2019; Kawakami et al, 2021), or administered by gel (Almasi et al, 2021;Sinha et al, 2016) To conclude, NE and ME are essential nanotechnological tools for the controlled, selective, safe, and effective transport of natural products against fungal infections. Natural products make the system even more biocompatible, contributing to the development of medicines composed of medicinal plants and using nanotechnological assistance in combating fungal resistance (Table 3).…”

Section: Nanoemulsionmentioning

confidence: 99%

See 1 more Smart Citation

Natural product‐based nanomedicine applied to fungal infection treatment: A review of the last 4 years

Marena

Ramos

Carvalho

et al. 2022

Phytotherapy Research

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Fungal infections are one of the main public health problems, especially in immunocompromised patients, nosocomial environments, patients with chronic diseases, and transplant recipients. These diseases are increasingly frequent and lethal because the microorganism has a high capacity to acquire resistance to available therapy. The main resistance factors are the emergence of new strains and the uncontrolled use of antifungals. It is, therefore, important to develop new methods that contribute to combating fungal diseases in the clinical area. Natural products have considerable potential for the development of new drugs with antifungal activity, mainly due to their biocompatibility and low toxic effect. This promising antimicrobial activity of natural products is mainly due to the presence of flavonoids, terpenes, and quinones, which explains their antifungal potential. Pharmaceutical nanotechnology has been explored to enhance the delivery, selectivity, and clinical efficacy of these products. Nanotechnological systems provide a safe and selective environment for various substances, such as natural products, improving antifungal activity. However, further safety experiments (in vivo or clinical trials) need to be carried out to prove the therapeutic action of natural products, since they may have undesirable, toxic, and mutagenic effects. Therefore, this review article addresses the main nanotechnological methods using natural products for effective future treatment against the main fungal diseases.

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Section: Future Nanotechnological Therapies For Fungal Infectionmentioning

confidence: 99%

Section: Nanoemulsionmentioning

confidence: 99%

Natural product‐based nanomedicine applied to fungal infection treatment: A review of the last 4 years

Marena

Ramos

Carvalho

et al. 2022

Phytotherapy Research

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“…These proved to be an efficient delivery system for the lipophilic natural compounds. through the skin against Leishmania parasites [144] . Formulation of nano-emulsions comprising synthetic chalcone showed stable leishmanicidal activity in in vitro studies [145] .…”

Section: Nano-emulsionsmentioning

confidence: 99%

Perceptions on therapeutic modalities regarding the virulence and immunity of cutaneous leishmaniasis

Saftawy

Hamed

Sameh

et al. 2021

Parasitologists United Journal

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“…The anti-inflammatory effects of P. emarginatus oleoresin from fruits Kawakami et al [ 136 ] was evaluated with the topical use of NE oleoresin at 20% (wt/wt) in combination with intraperitoneal (i.p.) meglumine antimoniate in the treatment of lesions caused by Leishmania (Leishmania) amazonensis.…”

Section: Nanotechnology As a Drug Delivery Strategy For Encapsulating...mentioning

confidence: 99%

Recent progress in micro and nano-encapsulation of bioactive derivatives of the Brazilian genus Pterodon

Lemos

Oliveira

Araújo

et al. 2021

Biomedicine & Pharmacotherapy

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Efficacy of nanoemulsion with Pterodon emarginatus Vogel oleoresin for topical treatment of cutaneous leishmaniasis

Cited by 25 publications

References 65 publications

Natural product‐based nanomedicine applied to fungal infection treatment: A review of the last 4 years

Natural product‐based nanomedicine applied to fungal infection treatment: A review of the last 4 years

Perceptions on therapeutic modalities regarding the virulence and immunity of cutaneous leishmaniasis

Recent progress in micro and nano-encapsulation of bioactive derivatives of the Brazilian genus Pterodon

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