Efficacy of mosapride citrate in proximal gastric accommodation and gastrointestinal motility in healthy volunteers: a double-blind placebo-controlled ultrasonographic study

Kusunoki, Hiroaki; Haruma, Ken; Hata, Jiro; Kamada, Takenobu; Ishii, Manabu; Yamashita, Naohito; Inoue, Kentaro; Imamura, Hiroshi; Manabe, Noriaki; Shiotani, Akiko

doi:10.1007/s00535-010-0292-7

Cited by 31 publications

(49 citation statements)

References 40 publications

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“…Ultrasonography has already been used clinically on humans, and gastric motility has been investigated in patients with functional dyspepsia [17], gastric ulcer [9], and diabetes with metabolic syndrome [26]. In addition, the prokinetic effect of 5HT 4 receptor agonist mosapride citrate was investigated using this ultrasonographic method [16]. In contrast, the significance of canine gastric motility is poorly understood because there have been limits to the use of previous assessment methods in clinical settings.…”

Section: Discussionmentioning

confidence: 99%

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Real-Time Ultrasonographic Evaluation of Canine Gastric Motility in the Postprandial State

Tsukamoto

Ohno

Tsukagoshi

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Gastric motility is affected by several pathological conditions which may induce upper gastrointestinal clinical symptoms. The pathogenesis of canine gastric motility disorders is poorly understood because of methodological limitations. This study aimed at establishing a simple method for evaluating postprandial gastric motility in dogs. Gastric motility was ultrasonographically assessed in 7 healthy beagles using a technique previously described in humans. The motility index (MI), an indicator of gastric antral motility, was calculated by measuring the area of the gastric antrum in both a contracted and relaxed phase and by counting the number of contractions. The MI was measured every 30 min for 3 hr after feeding and compared with gastric emptying as assessed by a 13 C-octanoic acid breath test. The MI at 30 min had the lowest variability in the 7 dogs (mean ± SD, 9.77  0.42; coefficient of variance, 4.25%), and a significant correlation was observed with gastric emptying coefficient (R 2 =0.8126, P=0.005) and half-emptying time (R 2 =0.654, P=0.027). When atropine was administered, a significant decrease in the MI at 30 min was observed compared with the control (9.77  0.42 vs. 5.19  0.22, P=0.0003). In conclusion, evaluation of the MI at 30 min is suitable for assessing gastric motility and enables us to assess gastric motility simply in a short time. By using this method, further studies for the pathogenesis of canine gastric motility disorders are warranted.KEY WORDS: 13 C-octanoic acid breath test, canine, gastric motility, motility index, ultrasonography.J. Vet. Med. Sci. 73(9): 1133-1138, 2011 Gastric motility disorders are caused secondary by several diseases or drug administration and possibly related with the pathogenesis of upper gastrointestinal clinical symptoms such as anorexia, vomiting, abdominal pain, and emesis. Several methods for evaluating gastric motility in both humans and dogs have been described [25,29]. Gastric motor activity has 2 characteristic phases: fasting and the postprandial phase. Many of the previous studies have focused on the postprandial phase. Postprandial gastric motility is assessed either by quantifying gastric emptying time and/or gastric antral motility or by detecting the electrical excitement caused by gastric movement. Gastric emptying can be evaluated using scintigraphy [1,14], a 13 Coctanoic acid breath test [8,31], or radiopaque markers [18,27], whereas gastric antral motility is examined using force transducers [13] or abdominal ultrasonography [5,7,9,19].Of these methods, scintigraphy is considered the gold standard for evaluating gastric emptying in both humans and dogs [22,29]. However, it requires a specialized facility and exposure to radiation. The 13 C-octanoic acid breath test is an indirect method of assessing gastric emptying using a non-radioisotope-labeled substrate. The test involves monitoring the rate of 13 CO 2 in expired air following ingestion of a test meal mixed with 13 C-octanoic acid. The 13 C-octanoic acid breath test has ...

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Section: Discussionmentioning

confidence: 99%

“…Ultrasonographic evaluation of gastric motility in humans has been applied in clinical settings, and several clinical trials have been performed to estimate the pathogenesis of gastric motility disorders on a large scale [9,16,17,26]. Previous reports have described the ultrasonographic assessment of gastric motility or emptying in dogs [7,19].…”

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confidence: 99%

Real-Time Ultrasonographic Evaluation of Canine Gastric Motility in the Postprandial State

Tsukamoto

Ohno

Tsukagoshi

et al. 2011

The Journal of Veterinary Medical Science

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“…Several pathophysiological causes of FD have been identified, such as delayed gastric emptying (Gilja et al, 1996;Quartero et al, 1998;Kusunoki et al, 2010;Karamanolis et al, 2006), abnormal antroduodenal motility (Stanghellini et al, 1992;Kusunoki et al, 2000), altered sensitivity to duodenal acid or lipid exposure (Burbera et al, 1995;Samson et al, 1999), visceral hypersensitivity (Mertz et al, 1998;Undeland et al, 1998), and impaired accommodation reflex (Salet et al, 1998;Tack et al, 1998). Among these, an impaired accommodation reflex is the most frequently observed pathophysiological condition in patients with FD.…”

Section: Figmentioning

confidence: 99%

“…However, the reproducibility of the measurements was not adequately evaluated. In this regard, we selected and confirmed some landmarks to ensure that the same portion of the stomach was analyzed throughout all the measurements (Hara et al, 2002;Kusunoki et al, 2010). Therefore, we believe that there is very little possibility of inconsistencies caused by human errors in this method.…”

Section: Figmentioning

confidence: 99%

Simple and non-invasive assessment of the accommodation reflex of the proximal stomach

Kusunoki

Haruma

Hara

et al. 2010

J Smooth Muscle Res

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Background: Impaired gastric accommodation of the proximal stomach is one of the major pathophysiological mechanisms in functional dyspepsia (FD). However, no useful method exists for the clinical evaluation of this phenomenon. Aim: The aim of the present study was to establish a simple and non-invasive method for evaluating the accommodation reflex of the proximal stomach. Methods: Nine healthy subjects received up to 1,700 mL water (stepwise administration in 100-mL increments) using a nasogastric tube while they were in a supine position. To assess the meal-induced gastric accommodation reflex, we measured the cross-sectional area of the proximal stomach via ultrasonography (US) at 3-min intervals after administration of water. We also measured the pressure of the water column using the same tube. Then, we administrated up to 400 mL of water in 100-mL increments and measured the area of the proximal stomach in 44 FD patients with early satiation (the measurements were performed at intervals of 3-min), and we compared the results with those for 44 healthy subjects. Results: The incremental changes in the area of the proximal stomach corresponded well with the amount of water administered. The area of the proximal stomach increased, but the antral area and the intragastric pressure remained relatively stable. After administration of more than 100 ml water, the area of the proximal stomach in healthy subjects was significantly greater than that in FD patients.

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“…In our previous study, we reported that extracorporeal ultrasonography (US) is a useful modality for the assessment of meal-induced gastric AR, gastric emptying rate (GER), antral contractions, and duodenogastric reflux (DGR) (17)(18)(19)(20)(21)(22). The aim of this study was to determine the clinical effects of Rikkunshito on gastric AR and gastroduodenal motility in FD patients by using US.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Rikkunshito, a Traditional Japanese Medicine (Kampo), in Treating Functional Dyspepsia

et al. 2010

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Background Rikkunshito, a traditional Japanese (Kampo) medicine, is widely prescribed as an oral preparation for the treatment of functional dyspepsia (FD). In our previous study, we reported that extracorporeal ultrasonography (US) is a useful technique for the assessment of the gastric accommodation reflex (AR) and duodenogastric motility. In this study, we examined the effects of Rikkunshito on the gastroduodenal function in patients with FD. Methods Sixteen FD patients (median age, 45 y) underwent US, before and after 14 days of treatment with Rikkunshito (7.5 g b.d.). For assessment of the AR, a cross-sectional area of the proximal stomach was measured after incremental ingestion of a liquid meal up to 400-mL. The expansion rate was used as the parameter to determine the AR. Then, the gastric emptying rate (GER), motility index (MI), and reflux index (RI) were evaluated using previously reported methods. Results Although no significant changes were observed in the total score of the Gastrointestinal Symptom Rating Scale (GSRS), the scores of 3 of the 15 symptoms of GSRS decreased significantly after treatment with Rikkunshito. The expansion rate of the proximal stomach was significantly greater after treatment with Rikkunshito than before the treatment. Although the GER and MI increased significantly, no significant differences in the RI were observed after treatment with Rikkunshito. Conclusion These observations suggested that Rikkunshito may be beneficial for the treatment of FD patients with impaired AR and gastric motility. These results also suggested that Rikkunshito has a therapeutic potential for FD and GERD.

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Efficacy of mosapride citrate in proximal gastric accommodation and gastrointestinal motility in healthy volunteers: a double-blind placebo-controlled ultrasonographic study

Abstract: This study shows that mosapride citrate enhances the meal-induced gastric accommodation reflex and promotes adequate gastroduodenal coordination and motility in healthy volunteers.

Cited by 31 publications

References 40 publications

Real-Time Ultrasonographic Evaluation of Canine Gastric Motility in the Postprandial State

Real-Time Ultrasonographic Evaluation of Canine Gastric Motility in the Postprandial State

Simple and non-invasive assessment of the accommodation reflex of the proximal stomach

Efficacy of Rikkunshito, a Traditional Japanese Medicine (Kampo), in Treating Functional Dyspepsia

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