Efficacy of mimetic viral dynein binding peptide binding nanoparticles in blood-brain barrier model

Liu, Nan; Li, Mingyuan; Xie, Fei; Lv, Jiaqi; Gào, Xīn; Zhang, Hui; Gao, Jing; Zheng, Anna

doi:10.1016/j.jddst.2022.103523

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…Active targeting is a key feature of nanomedicine in cancer therapy for enhancing drug reach-ability to the intended region, which leads to therapeutic success and reduces adverse effects [16,[106][107][108][109][110]. Various ligands may be linked to the surface of LPHNPs due to their structural specificity and multi-functionality, allowing for therapeutic targeting of tumorous sites [111][112][113][114][115][116] Antibodies [117,118], peptides [119,120] folate [121][122][123][124], transferrin [125][126][127][128] and aptamers [129][130][131][132][133][134] are some of the ligands employed for targeting LPHNPs. This nanocarrier system may also be proved effective for the oral route of drug administration against life-threatening diseases [135][136][137].…”

Section: Advantages Of Lphnpsmentioning

confidence: 99%

Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

Gajbhiye,

Salve,

Narwade

et al. 2023

Mol Cancer

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Lipid-based polymeric nanoparticles are the highly popular carrier systems for cancer drug therapy. But presently, detailed investigations have revealed their flaws as drug delivery carriers. Lipid polymer hybrid nanoparticles (LPHNPs) are advanced core–shell nanoconstructs with a polymeric core region enclosed by a lipidic layer, presumed to be derived from both liposomes and polymeric nanounits. This unique concept is of utmost importance as a combinable drug delivery platform in oncology due to its dual structured character. To add advantage and restrict one’s limitation by other, LPHNPs have been designed so to gain number of advantages such as stability, high loading of cargo, increased biocompatibility, rate-limiting controlled release, and elevated drug half-lives as well as therapeutic effectiveness while minimizing their drawbacks. The outer shell, in particular, can be functionalized in a variety of ways with stimuli-responsive moieties and ligands to provide intelligent holding and for active targeting of antineoplastic medicines, transport of genes, and theragnostic. This review comprehensively provides insight into recent substantial advancements in developing strategies for treating various cancer using LPHNPs. The bioactivity assessment factors have also been highlighted with a discussion of LPHNPs future clinical prospects. Graphical Abstract

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Section: Advantages Of Lphnpsmentioning

confidence: 99%

Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

Gajbhiye,

Salve,

Narwade

et al. 2023

Mol Cancer

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“…NAs enter the cytoplasm after being released from polyplexes.They should be bound to the transporter at this point to reach the site of therapeutic action, which could be the nuclei or other organelles (Figure 1). The cytoplasmic dynein seems to be a perfect intracellular transport molecule [96]. Some viruses use dynein during cellular infection due to the special protein sequences with the ability to bind with dynein light chain 8 (LC8) [97].…”

Section: Transport Through the Cytoplasm And Nuclear Localization Sig...mentioning

confidence: 99%

“…This feature can be transferred to non-viral carriers to increase their effective delivery of NA in the intracellular compartment. Thus, it has recently been demonstrated that a dyneinbinding peptide derived from the Ebola virus (VP35 protein) facilitates efficient cytoplasmic transport and can also be used for BBB passing [96]. PAMAM modified with a dynein LC8 binding module was successfully used during intracellular muscle delivery [98].…”

Section: Transport Through the Cytoplasm And Nuclear Localization Sig...mentioning

confidence: 99%

Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications

Shtykalova

Deviatkin

Freund

et al. 2023

Life

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Over the past decades, non-viral DNA and RNA delivery systems have been intensively studied as an alternative to viral vectors. Despite the most significant advantage over viruses, such as the lack of immunogenicity and cytotoxicity, the widespread use of non-viral carriers in clinical practice is still limited due to the insufficient efficacy associated with the difficulties of overcoming extracellular and intracellular barriers. Overcoming barriers by non-viral carriers is facilitated by their chemical structure, surface charge, as well as developed modifications. Currently, there are many different forms of non-viral carriers for various applications. This review aimed to summarize recent developments based on the essential requirements for non-viral carriers for gene therapy.

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Targeting inflammatory signaling in obsessive compulsive disorder: a promising approach

Bhatt,

Anitha,

Chellappan

et al. 2023

Metab Brain Dis

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Efficacy of mimetic viral dynein binding peptide binding nanoparticles in blood-brain barrier model

Cited by 3 publications

References 28 publications

Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications

Targeting inflammatory signaling in obsessive compulsive disorder: a promising approach

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