Efficacy of microwave versus radiofrequency ablation for treatment of small hepatocellular carcinoma: experimental and clinical studies

Gao, Qian; Wang, Neng; Shen, Qiang; Sheng, Yue Hong; Zhao, J.; Kuang, Ming; Liu, Guangjian; Wu, Mengchao

doi:10.1007/s00330-012-2442-1

Cited by 151 publications

(121 citation statements)

References 23 publications

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“…The authors considered a high probability of long-term survival of patients with a single lesion ≤4.0 cm in maximum diameter and Child-Pugh class A cirrhosis. Numerous studies have compared MWA with RFA for treating HCC and found similar disease-free survival, cumulative survival, and complication rates in the two groups [68,69,70,71,72,73,74]. However, so far, only one RCT [68] has compared the efficacy of MWA with that of RFA, in a series of 72 patients (36 RFA/36 MWA) with equivalent background demographics and mean tumor sizes.…”

Section: Local Ablative Therapymentioning

confidence: 99%

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

Shi

Zhai

2016

Gastrointest Tumors

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Background: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most common cause of cancer-related deaths. Hepatic resection and liver transplantation are considered to be the preferred treatment for HCC. However, as novel therapeutic options such as image-guided locoregional therapies have emerged and been refined, the manner in which HCC is treated has changed dramatically compared with what it was considered just 2 decades earlier. Summary: This study reviews the current results of various image-guided locoregional therapies for treating HCC, especially focusing on thermal ablative and transarterial techniques. Key Message: Advances in image-guided locoregional therapies, including local ablative therapy and transarterial therapy, have led to a major breakthrough in the management of HCC. Both survival rates and cure rates of patients with HCC have improved markedly since the introduction of these techniques. Practical Implications: Radiofrequency ablation is currently considered as an alternative to surgical resection for patients with early-stage HCC. A newer technique of ablation such as microwave ablation is increasingly being used, especially for large HCC. Transarterial chemoembolization has become a standard care for asymptomatic patients with multinodular tumors in intermediate-stage disease, and transarterial radioembolization has become the method of choice in HCC cases with portal vein thrombosis. Moreover, combination treatment modalities, such as thermal-based ablation combined with transarterial chemoembolization or ¹²⁵I seed implant brachytherapy, may further broaden their clinical indications for HCC. Moreover, use of localized radiation in combination with thermal ablation has been reported to improve tumor control and long-term survival.

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Section: Local Ablative Therapymentioning

confidence: 99%

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

Shi

Zhai

2016

Gastrointest Tumors

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“…Microwave ablation (MWA) is also utilised to generate thermal ablation. New devices have a greater burn area with a more consistent penumbra when compared to RFA [95,96]. These treatments are likely to have an evolving role in the future either in combination with resection or in isolation [97].…”

Section: Operative Approachmentioning

confidence: 99%

Surgery for Colorectal Liver Metastases

McNally

Parks²

2013

Dig Surg

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Half of all patients with colorectal cancer develop metastatic disease. The liver is the principal site for metastases, and surgical resection is the only modality that offers the potential for long-term cure. Appropriate patient selection for surgery and improvements in perioperative care have resulted in low morbidity and mortality rates, resulting in this being the therapy of choice for suitable patients. Modern management of colorectal liver metastases is multimodal incorporating open and laparoscopic surgery, ablative therapies such as radiofrequency ablation or microwave ablation and (neo)adjuvant chemotherapy. The majority of patients with hepatic metastases should be considered for resectional surgery, if all disease can be resected, as this offers the only opportunity for prolonged survival.

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“…[7] Although energy delivery was underpowered with respect to the maximum power output of the system, MCT yielded ablation areas comparable to those previously reported by other authors who performed MCT using a power output of 100 W and a 14-gauge cooled shaft antenna without choke device. [8] As the minichoked MWA system can also use a 14-gauge antenna with a power output of 100 W, it is hypothesizable that ablation areas even larger than those obtained in the above-mentioned in vivo comparison between MCT and RFA could be achieved using the maximum power output. Indeed, we treated some HCCs and liver metastases measuring up to 7 cm × 6 cm, performing two insertions of a 14-gauge minichoked antenna and using a power output of 90 W for a total ablation time of 20 min, achieving coagulation areas measuring up to 10 cm × 7 cm [ Figures 1 and 2].…”

Section: To the Editormentioning

confidence: 99%

Microwave coagulation therapy: the future is quite rosy

Tombesi¹,

Vece²,

Sartori³

2015

Hepatoma Res

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Efficacy of microwave versus radiofrequency ablation for treatment of small hepatocellular carcinoma: experimental and clinical studies

Abstract: MW ablation using a modified cooled-shaft antenna produces a larger ablation zone than RF ablation, with an efficacy similar to RF ablation in local tumour control. MW ablation is a safe and promising treatment of sHCC.

Cited by 151 publications

References 23 publications

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

Surgery for Colorectal Liver Metastases

Microwave coagulation therapy: the future is quite rosy

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