Efficacy of lycopene in the management of oral submucous fibrosis

Kumar, Abhinav; Bagewadi, Anjana; Keluskar, Vaishali; Singh, Mohit Pal

doi:10.1016/j.tripleo.2006.07.011

Cited by 150 publications

(118 citation statements)

References 14 publications

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“…Previous reports from Indian Subcontinent revealed maximum number of patients in the 21e30 yrs and 21e40 yrs age groups. 15,19 Maleefemale ratio, in our study is 6.9:1, is in accordance with a 6.8:1 ratio in a series of 239 patients reported by Pandya et al and other studies. 3,17,20 The higher involvement of males in all studies, reflects their easy access to the abusive habits when compared with females.…”

Section: Discussionsupporting

confidence: 94%

Prevalence of oral submucous fibrosis among habitual gutkha and areca nut chewers in Moradabad district

Nigam

Konidena

Dhillon³

et al. 2014

Journal of Oral Biology and Craniofacial Research

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Moradabad Gutkha chewersAreca nut a b s t r a c t Background: To determine the prevalence and severity of oral submucous fibrosis (OSMF) among habitual gutkha, areca nut and pan chewers of Moradabad, India.Method: A survey was conducted for a period of one year in east, west, north and south zones of Moradabad district, Uttar Pradesh. One thousand habitual chewers were selected as study participants, using a stratified random sampling technique, between the ages of 11e40 yrs, with a habit of chewing gutkha, areca nut, pan for over a year. A detailed history was recorded and meticulous clinical examination was conducted. Evaluation of taste sensation, hearing, interincisal distance, clinical staging was done in the OSMF patients found amongst habitual chewers. The obtained data was statistically analyzed using an SPSS 16.5 version soft ware.Results: The prevalence of OSMF was 6.3% (63/1000) and gutkha chewing was the most common abusive habit (42/63) amongst OSMF patients. Stage 1, Stage 2, Stage 3 OSMF was seen in 28, 19 and 16 patients respectively. Restricted mouth opening, altered taste perception and defective hearing was observed in 37/63 (58.7%), 24/63 (38.09%) and 14/63 (22.22%) respectively. Conclusion:Our study shows a prevalence of 6.3% OSMF among habitual chewers of Moradabad. Prevalence and severity were more in urban and rural patients respectively.

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Section: Discussionsupporting

confidence: 94%

Prevalence of oral submucous fibrosis among habitual gutkha and areca nut chewers in Moradabad district

Nigam

Konidena

Dhillon³

et al. 2014

Journal of Oral Biology and Craniofacial Research

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“…Our view is also supported by Chole et al [2] But it was contradicting with the findings of Kumar et al who stated that the results were better when lycopene is used alone. [3] In our study, the greater improvement in mouth opening when lycopene was combined with intralesional steroids may be attributed to the synergistic effect obtained when both the drugs were used together. Our study clearly demonstrates that Lycopene in combination with intralesional steroids and Hyaluronidase, is highly efficacious in improving the mouth opening and reducing other symptoms in patients with Oral Submucous Fibrosis.…”

Section: Ijmds • Wwwijmdsorg • July 2016; 5(2) 1232mentioning

confidence: 51%

“…Also Kumar et al suggests that severe cases of OSF are poor responders to lycopene. [3] So in our study, we included patients only with grade III and IV OSF. The improvement in mouth opening from baseline (before start of treatment) to week 6 was statistically significant among both groups.…”

Section: Ijmds • Wwwijmdsorg • July 2016; 5(2) 1232mentioning

confidence: 99%

“…[2] Arecanut chewing is deep rooted in Indian culture and has been used as a mouth freshening agent that has various symbolic roles throughout Indian history. [3] The most alarming fact is that this habit is becoming increasingly popular among adolescents. The ingredients of arecanut induce excessive reactive oxygen species which damages the cell structures, including lipids and membranes, proteins and nucleic acids.…”

Section: Introductionmentioning

confidence: 99%

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Use of Lycopene in the Management of Oral Submucous Fibrosis:A Clinical Study

Kaur

Singh

Goyal

2016

International Journal of Medical and Dental Sciences

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“…Protocol: Before the treatment sessions, mouth opening was assessed as the inter-incisal distance as measured from the mesio-incisal edge of the upper left central incisor tooth to the mesio-incisal edge of the lower left central incisor tooth. The measurement was made using a geometric divider and scale and was recorded in millimeters [7].…”

Section: Methodsmentioning

confidence: 99%