Use of Lycopene in the Management of Oral Submucous Fibrosis:A Clinical Study

Abstract

ABSTRACT

Comparative Efficacy of Interventions for the Management of Oral Submucous Fibrosis: A Systematic Review and Network Meta-Analysis

“…The general characteristics of the included studies are listed in Supplementary Table S4 [ 6 , 14 , 18 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ]. A total of 2063 patients are involved in the trials with most of the trials conducted in India, 1 trial conducted in Pakistan [ 50 ] and 2 trials conducted in China [ 6 , 47 ].…”

“…The clinical parameters assessed mentioned in the included randomized controlled trials consist of mouth opening, burning sensation, ulceration reduction, relief of fibrous bands, tongue protrusion, cheek flexibility, pain, speech, and swallowing difficulty. Out of 32 studies that measured mouth opening, 18 studies used vernier calipers [ 18 , 36 , 38 , 39 , 40 , 41 , 42 , 43 , 46 , 50 , 51 , 52 , 53 , 55 , 58 , 59 , 61 , 63 ], 3 studies used geometric scale/divider [ 14 , 39 , 60 ], 2 studies used sliding calipers [ 6 , 47 ], 3 studies used a metal scale/divider [ 37 , 56 , 62 ] and 7 studies did not mention any particular scale or divider [ 35 , 44 , 45 , 48 , 49 , 54 , 57 ]. Out of the 32 studies, 15 studies evaluated the burning sensation.…”

“…Out of the 32 studies, 15 studies evaluated the burning sensation. Most of the studies reported evaluation of burning sensation using the visual analogue scale (VAS) [ 6 , 14 , 18 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 46 , 47 , 48 , 49 , 51 , 52 , 54 , 55 , 58 , 59 , 60 , 61 , 62 , 63 ] while some studies evaluated burning sensation categorizing as absent, present and reduced [ 43 , 44 , 45 , 56 , 57 ] and 1 study evaluated the sensation as mild, moderate and severe [ 53 ]. Some studies reported pain, difficulty in speech and swallowing categorizing as absence, presence and reduction [ 44 , 45 , 48 , 57 ].…”

“…The primary outcome identified was the improvement in mouth opening (difference between post-treatment and pre-treatment). Most of the included studies demonstrated statistically significant improvement in mouth opening [ 14 , 35 , 36 , 38 , 40 , 41 , 42 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ].…”

Oral Submucous Fibrosis;

“…Kaur H et al 14 also conducted a study on this topic and concluded that Lycopene and intralesional steroids and Hyaluronidase is significantly effective in treatment of OSF by improving the mouth opening and reducing the symptoms of OSF there were no side effects were reported with its use.…”