Efficacy of Lycium barbarum polysaccharide and synergism with paclitaxel/cisplatin in ovarian cancer in mice

Zhu, Lei; Han, Yunguo; Wang, H.

doi:10.4314/tjpr.v16i7.25

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…67,68 Although such techniques have yet to be applied to LB, research using various multi-component LB extracts is ongoing. Synergism with other drugs, such as paclitaxel/ cisplatin in the treatment of ovarian cancer, 69 interferon-α2b in renal cell carcinoma, 70 and others, has also been observed.…”

Section: Composition: Single Component Versus Synergistic Blends In Rmentioning

confidence: 94%

Demystifying traditional Chinese medicines:Lycium barbarumas a model therapeutic

Manthey

Chiu

2018

Tradit. Med. Mod. Med.

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The practice of Traditional Chinese Medicine (TCM) focuses on holistic treatment of the body. This often includes preparation and application of medicinal herbs, either alone or in combination with other supplements. Lycium barbarum (LB), for example, is a commonly used herbal supplement in many Asian countries, being most well-known for improving kidney, liver, and eye health. It is also one of the most widely scientifically researched TCMs and a large body of literature is available describing its effects on various tissues and organ systems. In this perspective, we briefly expand upon how LB can be used as a model TCM in the systematic study of other herbal medicines, highlighting two of the primary barriers to their use in modern medicine worldwide.

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Section: Composition: Single Component Versus Synergistic Blends In Rmentioning

confidence: 94%

Demystifying traditional Chinese medicines:Lycium barbarumas a model therapeutic

Manthey

Chiu

2018

Tradit. Med. Mod. Med.

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“…Animals experiments have demonstrated that NPs from herbs could regulate Nrf2 antioxidant pathway for liver protection ( 14 , 36 , 41 , 54 , 57 , 67 , 116 , 120 , 147 – 153 ), kidney protection ( 21 , 59 , 154 – 157 ), lung protection ( 20 , 158 ), neuroprotection ( 22 , 121 ), cardioprotection ( 124 , 159 ), gastrointestinal protection ( 16 , 40 , 48 , 127 , 128 , 160 , 161 ), anti-oxidation ( 15 , 47 , 162 – 164 ), anti-diabetic ( 56 , 58 , 135 , 146 , 165 , 166 ), anti-aging ( 18 , 68 , 84 , 167 ), anti-inflammation ( 23 ), anti-depression ( 25 ), anti-cancer ( 168 ), and improving reproductive function ( 169 , 170 ), as implied in Table 1 .…”

Section: Regulation Of Nps On Nrf2 Antioxidant Pathway For Health-pro...mentioning

confidence: 99%

“…Lycium barbarum polysaccharide revealed anti-inflammation against cerulein-induced mice by adding nuclear Nrf2 protein expression and HO-1 activity in pancreas ( 23 ). Meanwhile, this polysaccharide implied anti-cancer action against ID-8 cells bearing-mice through up-regulation of mRNA and protein expressions of Keap1, Nrf2 and HO-1 in liver and kidney tissues ( 168 ). Polygonatum cyrtonema polysaccharide had anti-depression activity on LPS and CUMS-induced mice via increasing protein expressions of Nrf2 and HO-1 in hippocampal tissues ( 25 ).…”

Section: Regulation Of Nps On Nrf2 Antioxidant Pathway For Health-pro...mentioning

confidence: 99%

Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

Luo

Shen

et al. 2023

Front. Nutr.

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Natural polysaccharides (NPs) possess numerous health-promoting effects, such as liver protection, kidney protection, lung protection, neuroprotection, cardioprotection, gastrointestinal protection, anti-oxidation, anti-diabetic, and anti-aging. Nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway is an important endogenous antioxidant pathway, which plays crucial roles in maintaining human health as its protection against oxidative stress. Accumulating evidence suggested that Nrf2 antioxidant pathway might be one of key regulatory targets for the health-promoting effects of NPs. However, the information concerning regulation of NPs on Nrf2 antioxidant pathway is scattered, and NPs show different regulatory behaviors in their different health-promoting processes. Therefore, in this article, structural features of NPs having regulation on Nrf2 antioxidant pathway are overviewed. Moreover, regulatory effects of NPs on this pathway for health-promoting effects are summarized. Furthermore, structure-activity relationship of NPs for health-promoting effects by regulating the pathway is preliminarily discussed. Otherwise, the prospects on future work for regulation of NPs on this pathway are proposed. This review is beneficial to well-understanding of underlying mechanisms for health-promoting effects of NPs from the view angle of Nrf2 antioxidant pathway, and provides a theoretical basis for the development and utilization of NPs in promoting human health.

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Lycium barbarum (Goji) as functional food: a review of its nutrition, phytochemical structure, biological features, and food industry prospects

Zhang

et al. 2022

Critical Reviews in Food Science and Nutrition

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Efficacy of Lycium barbarum polysaccharide and synergism with paclitaxel/cisplatin in ovarian cancer in mice

Abstract: Purpose: To determine the efficacy of Lycium barbarum polysaccharide (LBP) in ovarian cancer, and the synergistic effect when used in combination with paclitaxel/cisplatin (PXT∕DDP

Cited by 3 publications

References 19 publications

Demystifying traditional Chinese medicines:Lycium barbarumas a model therapeutic

Demystifying traditional Chinese medicines:Lycium barbarumas a model therapeutic

Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

Lycium barbarum (Goji) as functional food: a review of its nutrition, phytochemical structure, biological features, and food industry prospects

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