<i>Lycium barbarum</i>
            (Goji) as functional food: a review of its nutrition, phytochemical structure, biological features, and food industry prospects

Ma, Run-Hui; Zhang, Xiuxiu; Ni, Zhi‐Jing; Thakur, Kiran; Wang, Wei; Yan, Yamei; Cao, Yang; Zhang, Jianguo; Rengasamy, Kannan R.R.; Wei, Zhao‐Jun

doi:10.1080/10408398.2022.2078788

Cited by 34 publications

(36 citation statements)

References 94 publications

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“…77 Fifteen conjugated spermidines (Lycibarbar spermidines A−O) were only observed in Lycium berries. 77 These compounds exhibit a distinctive structural characteristic: spermidine is linked to hydroxycinnamic acid and subsequently conjugated with hexoside. Similarly in barley, agmatine conjugated with hexoside has also been discovered, for example, p-coumaroyl agmatine hexoside, feruloyl agmatine hexoside, and sinapoyl agmatine hexoside.…”

Section: Sources and Quantitiesmentioning

confidence: 99%

Section: Identification Sources and Quantities Of Cpasmentioning

confidence: 99%

“…In addition, CPAs have been identified in Solanaceae plants such as tomatoes and Lycium berries . Fifteen conjugated spermidines (Lycibarbar spermidines A–O) were only observed in Lycium berries . These compounds exhibit a distinctive structural characteristic: spermidine is linked to hydroxycinnamic acid and subsequently conjugated with hexoside.…”

Section: Identification Sources and Quantities Of Cpasmentioning

confidence: 99%

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New Insights into Identification, Distribution, and Health Benefits of Polyamines and Their Derivatives

Qiao,

Cai,

Wang

et al. 2024

J. Agric. Food Chem.

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Polyamines and their derivatives are ubiquitously present in free or conjugated forms in various foods from animal, plant, and microbial origins. The current knowledge of free polyamines in foods and their contents is readily available; furthermore, conjugated polyamines generate considerable recent research interest due to their potential health benefits. The structural diversity of conjugated polyamines results in challenging their qualitative and quantitative analysis in food. Herein, we review and summarize the knowledge published on polyamines and their derivatives in foods, including their identification, sources, quantities, and health benefits. Particularly, facing the inherent challenges of isomer identification in conjugated polyamines, this paper provides a comprehensive overview of conjugated polyamines' structural characteristics, including the cleavage patterns and characteristic ion fragments of MS/MS for isomer identification. Free polyamines are present in all types of food, while conjugated polyamines are limited to plant-derived foods. Spermidine is renowned for antiaging properties, acclaimed as antiaging vitamins. Conjugated polyamines highlight their anti-inflammatory properties and have emerged as the mainstream drugs for antiprostatitis. This paper will likely help us gain better insight into polyamines and their derivatives to further develop functional foods and personalized nutraceuticals.

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Section: Sources and Quantitiesmentioning

confidence: 99%

Section: Identification Sources and Quantities Of Cpasmentioning

confidence: 99%

Section: Identification Sources and Quantities Of Cpasmentioning

confidence: 99%

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New Insights into Identification, Distribution, and Health Benefits of Polyamines and Their Derivatives

Qiao,

Cai,

Wang

et al. 2024

J. Agric. Food Chem.

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“…L. barbarum contains many phytochemicals and nutrients, including carotenoids, flavonoids, zeaxanthin, Lycium barbarum polysaccharides (LBP), fats, proteins, vitamins, and mineral elements. [16] LBP, the main active ingredients in the fruit of L. barbarum, have been reported to have some health benefits, such as anti-inflammatory, [15] antioxidant, [17,18] hypoglycemic and hypolipidemic [19][20][21] properties in recent years. Because of these health properties, L. barbarum has excellent potential as a functional food [15,22] and for the prevention of age-related diseases, including cardiovascular disease, [23] neurodegenerative diseases, [24] type 2 diabetes, [25] and age-related macular degeneration.…”

Section: Introductionmentioning

confidence: 99%

“…[16] LBP, the main active ingredients in the fruit of L. barbarum, have been reported to have some health benefits, such as anti-inflammatory, [15] antioxidant, [17,18] hypoglycemic and hypolipidemic [19][20][21] properties in recent years. Because of these health properties, L. barbarum has excellent potential as a functional food [15,22] and for the prevention of age-related diseases, including cardiovascular disease, [23] neurodegenerative diseases, [24] type 2 diabetes, [25] and age-related macular degeneration. [26] Results from previous animal models and clinical studies have suggested that L. barbarum has the potential to lower lipid concentrations.…”

Section: Introductionmentioning

confidence: 99%

L. barbarum (Lycium barbarum L.) supplementation for lipid profiles in adults: A systematic review and meta-analysis of RCTs

Zeng,

Zhao,

Wang

et al. 2023

Medicine

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Background: Dyslipidemia is a global health concern with an increasing prevalence worldwide. Lycium barbarum (L. barbarum) is widely used as a medicinal and functional food, and evidence suggests that it may be beneficial for lipid management. In this study, we performed a systematic review and meta-analysis of randomized controlled trials investigating the effects of L. barbarum supplementation on lipid profiles in adults. Methods: PubMed, China National Knowledge Infrastructure, The Cochrane Library, Web of Science, and Wanfang Database were searched from inception until October 2022. The random-effect model was applied, and the pooled effect sizes were expressed as mean differences (MDs) and 95% confidence intervals (CIs). Results: The meta-analysis of 5 randomized controlled trials involving 259 subjects indicated that L. barbarum supplementation significantly decreased the triglyceride (TG) concentration (MD: 0.14 mmol/L, 95% CI: 0.08–0.20) and increased the high-density lipoprotein cholesterol concentration (HDL-C) (MD: −0.07 mmol/L, 95% CI: −0.13 to −0.01). However, the reductions in total cholesterol (TC) concentration (MD: 0.11 mmol/L, 95% CI: −0.37 to 0.59) and low-density lipoprotein cholesterol (LDL-C) concentration (MD: 0.21 mmol/L, 95% CI: −0.46 to 0.89) were not statistically significant. Conclusion: The present study showed that L. barbarum supplementation might have some beneficial effects on TG and HDL-C concentrations in adults, and L. barbarum fruit has an even greater effect on TG and HDL-C concentrations. Considering the sensitivity analyses and limitations of the study included, further large-scale studies are needed to confirm these findings.

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Supercharging metabolic health with Lycium barbarum L.: A review of the therapeutic potential of this functional food for managing metabolic syndrome

Sharifi‐Rad,

Quetglas‐Llabrés,

Sureda

et al. 2024

Food Frontiers

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Metabolic syndrome (MetS) is a common disorder involving a cluster of metabolic abnormalities, such as abdominal obesity, hypertension, dyslipidemia, insulin resistance, and atherogenic profile. MetS is characterized by an increase in oxidative stress and a chronic proinflammatory state, which are directly related to the development and progression of this pathology. It has been seen how a healthy lifestyle and good dietary practices are key to improving the different metabolic parameters and, therefore, play a fundamental role in reducing the risk of developing diabetes. The present review focuses on the research evidence related to the therapeutic properties of Lycium barbarum L. in MetS gathered in the last years. Several preclinical studies suggest that L. barbarum extracts are a good dietary supplement for the prevention of cardiovascular diseases in people with MetS. This compound has been used for years in traditional Chinese medicine for the treatment of atrophic gastritis, problems related to the lungs, kidneys, and liver, and as a supplement for eye health. In addition, different in vitro and in vivo studies have been carried out that support the properties attributed to metabolites derived from L. barbarum, such as polysaccharides that have been shown diverse biological activities. In conclusion, L. barbarum extracts have multiple benefits to increase general well‐being and immune function. However, there are a limited number of studies related to effect of L. barbarum in MetS, but they demonstrated effectiveness in the treatment of obesity, diabetes mellitus type 2, and prevention of diabetes mellitus type 2 complication.

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Lycium barbarum (Goji) as functional food: a review of its nutrition, phytochemical structure, biological features, and food industry prospects

Cited by 34 publications

References 94 publications

New Insights into Identification, Distribution, and Health Benefits of Polyamines and Their Derivatives

New Insights into Identification, Distribution, and Health Benefits of Polyamines and Their Derivatives

L. barbarum (Lycium barbarum L.) supplementation for lipid profiles in adults: A systematic review and meta-analysis of RCTs

Supercharging metabolic health with Lycium barbarum L.: A review of the therapeutic potential of this functional food for managing metabolic syndrome

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