Efficacy of low‐fat milk and yogurt fortified with encapsulated vitamin D₃on improvement in symptoms of insomnia and quality of life: Evidence from the SUVINA trial

Abstract

Introduction Sleep disorders are a common condition globally. Vitamin D receptors are present on cells in several regions of the brain. It is possible that vitamin D status may affect brain function, including sleep patterns. We aimed to evaluate the 1,500 IU of Nano‐encapsulated vitamin D fortified in dairy products on the symptoms of insomnia and associated improvement of quality of life. Methods A case series was undertaken as part of the Survey of ultraviolent intake by nutritional approach project. Subjects enrolled among adults with abdominal obesity. Twenty‐nine subjects with insomnia were selected according to the results of Insomnia Severity Index questionnaire and quality of life using a Short Form Health Survey (SF‐36) questionnaire. Subjects were allocated to four groups: low‐fat milk fortified by 1,500 IU vitamin D3 (n = 8), simple milk (n = 8), low‐fat yogurt fortified by 1,500 IU vitamin D3 (n = 7), and simple yogurt (n = 6) and were treated for 10 weeks. Results The insomnia score improved after the intervention in the group receiving vitamin D fortified milk compared to group receiving unfortified milk (p < .001). There were no significant differences between the two groups taking yogurt (fortified vs. unfortified). Comparison of quality of life scores between baseline and after intervention indicated significant improvements in both fortified and simple milk groups (p = .002 and p = .03, respectively); but no differences were found in the groups taking yogurt. Conclusion Fortified low‐fat milk containing 1,500 IU vitamin D3 can improve insomnia symptoms and subsequently quality of life. Trial registration number: IRCT20101130005280N27, http://www.IRCT.ir.

Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies

“…Out of the 19,051 screened records, 19 studies were included in this systematic review. Out of these studies, thirteen were RCTs [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ], one was an opportunistic addition to an established randomized, double-blind, placebo-controlled trial [ 37 ], four were pre–post studies [ 38 , 39 , 40 , 41 ], and one was a self-controlled before–after trial, analyzed retrospectively as a case series [ 42 ].…”

“…Table 1 demonstrates the characteristics of the included studies. Six of the studies were conducted in Iran [ 25 , 27 , 30 , 31 , 34 , 39 ], five in the USA [ 28 , 29 , 32 , 33 , 42 ], one in Ireland [ 26 ], one in New Zealand [ 37 ], one in KSA [ 35 ], one in China [ 36 ], one in Turkey [ 40 ], and one in the Netherlands [ 24 ]. The number of participants varied from 5 [ 31 ] to 18,353 [ 32 ].…”

“…One study was conducted in patients receiving maintenance methadone treatment [ 25 ], one in active-duty warfighters [ 29 ], one on veterans with multiple areas of chronic pain and low serum 25(OH)D [ 42 ], one on adult patients with urticarial [ 33 ], one on fibromyalgia syndrome patients [ 30 ], one in patients with chronic low back pain [ 41 ], and one on patients with depression with tied anxiety symptoms [ 36 ]. Finally, one study was conducted on adults with OSA [ 26 ], one on adults with sleep disorders [ 27 ], two in patients with RLS [ 35 , 38 ], and one on adults with vitamin D deficiency, abdominal obesity, and symptoms of insomnia [ 34 ].…”

Microencapsulation of Bioactive Ingredients for Their Delivery into Fermented Milk Products: A Review

“…Some publications presented research on yogurt fortification with vitamin D 3, which is fat-soluble and susceptible to the degradation by low pH, UV, and oxidation [ 46 , 47 , 48 ]. Vitamin D 3 was delivered in the form of spray-dried nanoliposomes [ 49 ], nanocapsules based on the lipid carrier precirol [ 50 ], oil-in-water emulsion stabilized by whey protein or by whey protein plus carboxymethylcellulose [ 51 ], or encapsulated in re-assembled casein micelles [ 50 ]. Encapsulated vitamin D 3 showed the high stability against deterioration during the shelf life of yogurt.…”

Use of alpha-casozepine (Lactium®) and vitamin B6 in clinical practice (literature review)

“…Встановлено, що білки, отримані з молочних продуктів, містять біоактивні пептидні послідовності з різними перевагами для здоров'я, з ефектами від трав ної системи до серцево судинної циркуляції, імунної системи та центральної нервової систе ми. Серед них -опіоїдні антагоністи, інгібіто ри ангіотензинперетворювального ферменту (АПФ), імуностимулюючі пептиди, інгібітори агрегації тромбоцитів, фосфопептиди -носії мінералів (Ca 2+ , Fe 2+ ), мітогенні пептиди, анти бактеріальні пептиди та інгібітори протеази [9,37,38]. Нещодавно повідомлялося про здат ність молочних білків модулювати метаболізм та апетит [16].…”