Efficacy of Low-Dose Corticosteroid Therapy Versus High-Dose Corticosteroid Therapy in Bell’s Palsy in Children

Arıcan, Pınar; Dündar, Nihal Olgaç; Gençpınar, Pınar; Çavuşoğlu, Dilek

doi:10.1177/0883073816668774

Cited by 13 publications

(14 citation statements)

References 24 publications

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“…However, steroid is widely used in the treatment of Bell's palsy in children, and the dosage is unclear. Arican et al 27 compared the patients treated with 1 mg/kg/d prednisolone to 2 mg/ kg/d prednisolone in terms of recovery rate, and they found no significant difference in complete recovery between the groups. In our study, although the early recovery rate was statistically significant in patients who received 1 mg/kg/d prednisolone (P ¼ .04), according to the multiple logistic regression model, the effect of steroid dosage (1 mg/kg/d vs 2 mg/kg/d) on early recovery was not detected.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors Associated With Recovery in Children With Bell’s Palsy

Karatoprak

Yılmaz

2019

J Child Neurol

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Objectives: The aim of the study was to determine the prognosis of children with Bell’s palsy and analyze the prognostic factors affecting early recovery. Methods: The records of children with a diagnosis of Bell’s palsy were retrospectively analyzed. Demographic and clinical features including age, gender, House-Brackmann Facial Nerve Grading System House-Brackmann Grading Scale (HBGS) grade at admission and follow-up, and the dosage and onset of steroid treatment were reviewed. Laboratory findings such as red blood cell distribution width and neutrophil-to-lymphocyte ratio were noted. The patients who were recovered within the first month (early recovery) were compared with the patients who were recovered after first month (late recovery) in terms of demographic, clinical characteristics, laboratory findings and treatment modalities in order to determine the risk factors affecting early recovery. Results: A total of 102 children (65 girls and 37 boys) with a mean age of 10.37 ± 4.2 years were included in the study. The complete recovery was detected in 101 children (%99) with Bell’s palsy. Statistically significant difference was found in terms of dosage and time of onset of steroid treatment ( P = .04, P = .035, respectively) and House-Brackmann Facial Nerve Grading System grade on the 10th day ( P = .001) between the early and late recovery groups. Conclusion: The prognosis of Bell’s palsy in children was very good. The prognostic factors affecting the early recovery were being House-Brackmann Facial Nerve Grading System grade 2 or 3 on the 10th day and receiving steroid treatment in the first 24 hours. Neutrophil-to-lymphocyte ratio and red blood cell distribution width were not found to be predictive factors for early recovery.

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Section: Discussionmentioning

confidence: 99%

Prognostic Factors Associated With Recovery in Children With Bell’s Palsy

Karatoprak

Yılmaz

2019

J Child Neurol

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“…Another prospective study of children <15 years of age from Germany showed a recovery rate of 97% without any use of steroids [ 1 ]. Unlike this previous study, Arican et al [ 11 ] reported that oral corticosteroid was highly effective in the treatment of Bell’s palsy in children, even at a dose of 1 mg/kg/day of oral prednisolone.…”

Section: Discussionmentioning

confidence: 63%

“…Chen and Wong [ 10 ] showed that the mean age of Bell’s palsy onset in children was 6 years 7 months, 52% of patients were male, and that 44.4% of patients had right-sided Bell’s palsy. In another study, Arican et al [ 11 ] reported that the mean age of Bell’s palsy onset was 11 years, 59% of patients were female, and that 47% of patients had right-sided Bell’s palsy. In our study, the mean age of Bell’s palsy onset was 7 years 4 months, 50% of patients were female, and 49% of patients showed right-sided Bell’s palsy.…”

Section: Discussionmentioning

confidence: 99%

Comparison of conservative therapy and steroid therapy for Bell’s palsy in children

et al. 2018

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PurposeBell’s palsy is characterized by sudden onset of unilateral facial weakness. The use of corticosteroids for childhood Bell’s palsy is controversial. This study aimed to identify clinical characteristics, etiology, and laboratory findings in childhood Bell’s palsy, and to evaluate the efficacy of corticosteroid treatment.MethodsWe conducted a retrospective analysis of children under 19 years of age treated for Bell’s palsy between January 2009 and June 2017, and followed up for over 1 month. Clinical characteristics, neuroimaging data, laboratory findings, treatments, and outcomes were reviewed. Patients with Bell’s palsy were divided into groups with (group 1) and without (group 2) corticosteroid treatment. Differences in onset age, sex, laterality, infection and vaccination history, degree of facial nerve palsy, and prognosis after treatment between the groups were analyzed.ResultsOne hundred patients were included. Mean age at presentation was 7.4±5.62 years. A total of 73 patients (73%) received corticosteroids with or without intravenous antiviral agents, and 27 (27%) received only supportive treatment. There was no significant difference in the severity, laboratory findings, or neuroimaging findings between the groups. Significant improvement was observed in 68 (93.2%) and 26 patients (96.3%) in groups 1 and 2, respectively; this rate was not significantly different between the groups (P=0.48).ConclusionChildhood Bell’s palsy showed good prognosis with or without corticosteroid treatment; there was no difference in prognosis between treated and untreated groups. Steroid therapy in childhood Bell’s palsy may not significantly improve outcomes.

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“…Once she was diagnosed with both conditions, she was prescribed a 10-day course of acyclovir 400 mg TID and a 14-day tapering course of PO prednisone. Corticosteroids for acute Bell's palsy are recommended to improve long-term recovery in adults and children,13 14 and recent research shows moderate evidence that corticosteroid plus antiviral treatment increases complete recovery with no significant adverse events 15. In addition, there has been some evidence, although not yet conclusive, that acyclovir may reduce the duration and pruritus of PR, and a low dose (as prescribed here) is as effective as a higher dose in achieving outcomes 16.…”

Section: Treatmentmentioning

confidence: 91%

Concurrent pityriasis rosea and Bell's palsy

Voss

Mattox

Guo³

2017

BMJ Case Reports

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Pityriasis rosea is a dermatological disease with a well-documented clinical appearance, but less is known about causes and treatment. Bell's palsy is a neurological condition leading to acute idiopathic hemifacial paralysis. Recent studies indicate that human herpesvirus (HHV) 6-7 reactivation may be a contributing factor to both conditions. We report a case of the 2 concurrent diagnoses that supports a common contributing factor and suggests further awareness and research into the role HHV 6-7 may play in the aetiology of both conditions.

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Efficacy of Low-Dose Corticosteroid Therapy Versus High-Dose Corticosteroid Therapy in Bell’s Palsy in Children

Cited by 13 publications

References 24 publications

Prognostic Factors Associated With Recovery in Children With Bell’s Palsy

Prognostic Factors Associated With Recovery in Children With Bell’s Palsy

Comparison of conservative therapy and steroid therapy for Bell’s palsy in children

Concurrent pityriasis rosea and Bell's palsy

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