Efficacy of Lithium as Acute Treatment of Manic-Depressive Illness

Stokes, P.; Shamoian, CharlesA.; Stoll, P.; Patton, MichaelJ.

doi:10.1016/s0140-6736(71)91886-1

Cited by 168 publications

(55 citation statements)

References 8 publications

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“…Three studies permitted the use of bipolar disorder [4][5][6][7][8][9][10][11][12]. Of these nine studies, only Stokes et al [7] were unable to demonstrate that lithium was mood stabilizers [15,16,19], but only one standardized their use [19]. Responder analyses were usually carried more effective than placebo, but this study was primarily designed to evaluate the lithium's acute efficacy in mania.…”

Section: Lithium Studies In Bipolar Depressionmentioning

confidence: 99%

Clinical Studies on the Use of Lamotrigine in Bipolar Disorder

et al. 1998

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New mood stabilizers that possess efficacy in the depressed phase of bipolar disorder are needed. The use of marketed antidepressants puts bipolar patients at some increased risk for drug-induced hypomania/mania and rapid cycling. During the development of the antiepileptic, lamotrigine, the drug was observed to improve mood, alertness, and social interactions in some patients with epilepsy. These early observations provided the rationale for investigations into lamotrigine’s potential efficacy in bipolar disorder. There are now 14 open clinical reports involving a total of 207 lamotrigine-treated patients with bipolar disorder that suggest this drug possesses a broad spectrum of efficacy in the management of the depressed, hypomanic, manic, and mixed phases of bipolar disorder. In an attempt to replicate and extend these preliminary open-label prospective findings, a series of multicenter, double-blind, placebo-controlled studies evaluating the efficacy and dose-response relationships of lamotrigine in the various phases of the illness, including both acute and maintenance designs in both bipolar I and II disorder, is ongoing.

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Section: Lithium Studies In Bipolar Depressionmentioning

confidence: 99%

Clinical Studies on the Use of Lamotrigine in Bipolar Disorder

et al. 1998

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“…One study of naturalistic LI treatment in mixed-age manic patients suggested that benefit was attenuated by increased age [112]; however, only four 854 YOUNG patients in this study were elderly. No age effect was reported in a placebocontrolled study of the efficacy of LI in mixed-age manic patients, 18% of whom were 60 years of age or older [113]. Apparently, no analyses address age effects on VAL or CBZ efficacy in mania.…”

Section: What Factors May Modify Acute Efficacy?mentioning

confidence: 99%

Evidence-Based Pharmacological Treatment of Geriatric Bipolar Disorder

Young

2005

Psychiatric Clinics of North America

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“…Stokes e cols. (1971) 101 conduziram um estudo controlado com 18 pacientes BP I e não encontraram resposta significativa do lítio, em relação ao placebo. Entretanto, esse estudo teve um período considerado curto (10 dias) para que se tivesse uma resposta antidepressiva esperada.…”

Section: Depressão Bipolarunclassified

Neurobiologia do transtorno de humor bipolar e tomada de decisão na abordagem psicofarmacológica

Machado‐Vieira

Schwartzhaupt²,

Frey

et al. 2003

Rev. psiquiatr. Rio Gd. Sul

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INTRODUÇÃOO Transtorno do Humor Bipolar (THB) caracteriza-se por oscilações do humor que causam prejuízos significativos no âmbito biopsicossocial, com critérios específicos para seus subdiagnósticos (DSM-IV). O surgimento de novos fármacos com propriedade de estabilizar o humor, o refinamento diagnóstico, as estimativas de uma maior prevalência, o risco de suicídio, assim como os prejuízos sociais causados para o indivíduo portador do transtorno, sua família e a sociedade enfatizam a importân-cia de cada vez mais este transtorno ser estudado de forma sistemática, continuada e críti-ca. Este artigo avalia criticamente as opções já estudadas para tratamento farmacológico dos diferentes subtipos de THB, avaliando sua eficácia para as indicações específicas, bem como as perspectivas de novos estudos com fárma-cos que ainda apresentam resultados limitados, especialmente devido à não sistematização dos estudos clínicos feitos até o presente momento. FÁRMACOS UTILIZADOS E MECANISMOS DE AÇÃO LítioO lítio interfere no metabolismo do inositol trifosfato, responsável pela liberação do cálcio de seus depósitos intracelulares, possivelmente através da inibição de enzimas na rota de formação do inositol2,3. Há também outras hipóteses que justificam seu uso como estabilizador do humor:-por sua similaridade com outros elementos (sódio, potássio, cálcio e magnésio), eleva Neurobiologia do transtorno de humor bipolar e tomada de decisão na abordagem psicofarmacológica

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Efficacy of Lithium as Acute Treatment of Manic-Depressive Illness

Cited by 168 publications

References 8 publications

Clinical Studies on the Use of Lamotrigine in Bipolar Disorder

Clinical Studies on the Use of Lamotrigine in Bipolar Disorder

Evidence-Based Pharmacological Treatment of Geriatric Bipolar Disorder

Neurobiologia do transtorno de humor bipolar e tomada de decisão na abordagem psicofarmacológica

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