Efficacy of lifestyle interventions in reducing diabetes incidence in patients with impaired glucose tolerance: A systematic review of randomized controlled trials

Yoon, Uzung; Kwok, Lai Lai; Magkidis, Athanasios

doi:10.1016/j.metabol.2012.07.009

Cited by 113 publications

(77 citation statements)

References 62 publications

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“…The effect tended to tail away during the silent period, which is clearly seen in the trend of the Metabolic Syndrome (Figure 1). This "tailing away effect" has also been reported previously [47]. In the case of waist circumference, the results indicated that even a very strong motivator, such as knowledge of personal genetic risk may not be powerful enough to stimulate a permanent life style change for preventing lifestyle diseases.…”

Section: Discussionsupporting

confidence: 73%

Using Individual, ApoE Genotype-Based Dietary and Physical Activity Advice to Promote Healthy Lifestyles in Finland—Impacts on Cardiovascular Risk Markers

Hietaranta-Luoma¹,

Åkerman²,

Tahvonen³

et al. 2015

OJPM

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Aim: There is increasing demand for individualized health advice. The aim of this study was to assess the effects on cardiovascular risk markers of receiving personal genetic health information, using apoE genotypes as a tool for promoting lifestyle changes. ApoE was chosen because it had a significant impact on lipid metabolism and cholesterol absorption, all factors for CVD. Methods: This study was a one-year explanatory intervention study for healthy adults, aged between 20 -67 years old (n = 106). Their clinical markers (serum lipids, blood glucose, blood pressure, Body Mass Index, body fat percentage and waist circumference) were measured three times during the intervention. The clinical effects were assessed for three groups: a high risk group (Ɛ4+, n = 16); a low-risk group (Ɛ4−, n = 35); and a control group (n = 55). Results: The triglyceride values and waist circumference lowered more in Ɛ4+ compared with the control group (p < 0.05; alpha value 0.005) during the intervention. Conclusion: The personal genetic information, based on apoE, may have positive effects on cardiovascular risk markers (e.g., improvement in triglyceride values). The individual health information, based on genotyping could be a potential option in the prevention of CVD. More research is required on how to utilize genotype-based health information in the prevention of lifestyle-related diseases.

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Section: Discussionsupporting

confidence: 73%

Using Individual, ApoE Genotype-Based Dietary and Physical Activity Advice to Promote Healthy Lifestyles in Finland—Impacts on Cardiovascular Risk Markers

Hietaranta-Luoma¹,

Åkerman²,

Tahvonen³

et al. 2015

OJPM

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“…In routine clinical practice, the proportion of those not achieving permanent lifestyle changes is probably even greater, albeit with unclear consequences. Although a recent systematic review reported a rapid loss of beneficial effects on the onset of diabetes after lifestyle interventions have been stopped [60], some long-term observational data indicate that beneficial effects can be maintained for up to 23 years [59,61,62]. Despite such challenges, beneficial effects found in prevention trials are applicable to real world situations.…”

Section: Discussionmentioning

confidence: 99%

“…Fifth, we hardly found any data on sex-specific differences with respect to diabetes-related longterm complications, in particular cardiovascular disease and microvascular complications, or risk of harms. Observational studies on diabetes prevention analysing long-term complications of diabetes are rare [60] and were not analysed in our review. It is conceivable though that a reduction of the incidence of type 2 diabetes will lead to a reduction of long-term complications of the disease.…”

Section: Discussionmentioning

confidence: 99%

Sex-specific differences in diabetes prevention: a systematic review and meta-analysis

et al. 2014

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Aims/hypothesis In people with prediabetes, lifestyle interventions and glucose-lowering medications are effective in preventing the progression to type 2 diabetes. It is unclear whether differences in treatment effects between men and women need to be taken into consideration when choosing a preventive strategy for an individual person. Methods We systematically searched PubMed, the Cochrane Library, EMBASE, CINAHL, Web of Science, and reference lists of pertinent review articles from 1980 to June 2013. We conducted random effects meta-analyses of published and unpublished data to determine differences of treatment effects between men and women. Conclusions/interpretation Our study emphasises the importance of preventive interventions in people with prediabetes and indicates no differences of beneficial preventive effects on the incidence of type 2 diabetes and weight gain between men and women.

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“…There is increasing acknowledgement that the best way to do this is through studies which have an explicit focus on generalisation and feasibility and which report information on contextual variables such as representativeness, reach, implementation and adaption, costs and other outcomes important to policy makers [21,40,41].…”

Section: Diabetes Prevention Program Outcomes Study (Dppos)mentioning

confidence: 99%

Type 2 Diabetes Prevention Programs; How Far are we?

G¹

2014

J Diabetes Metab

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Efficacy of lifestyle interventions in reducing diabetes incidence in patients with impaired glucose tolerance: A systematic review of randomized controlled trials

Cited by 113 publications

References 62 publications

Using Individual, ApoE Genotype-Based Dietary and Physical Activity Advice to Promote Healthy Lifestyles in Finland—Impacts on Cardiovascular Risk Markers

Using Individual, ApoE Genotype-Based Dietary and Physical Activity Advice to Promote Healthy Lifestyles in Finland—Impacts on Cardiovascular Risk Markers

Sex-specific differences in diabetes prevention: a systematic review and meta-analysis

Type 2 Diabetes Prevention Programs; How Far are we?

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