Efficacy of intratympanic corticosteroid, intravenous batroxobin and combined treatment for sudden sensorineural hearing loss with type-2 diabetes

Jia, Hongyan; Zhan, Yuan; Li, Xiping; Wang, Jianhong; Ge, Xiaohui; Chen, Zhiting; Huang, Xiande; Wei, Yongxiang

doi:10.1080/00016489.2019.1592221

Cited by 9 publications

(9 citation statements)

References 18 publications

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“…The result demonstrated that the comparison of the total effective rate and efficacy of the treatment of diabetes patients with SHL by posterior auricular and tympanum injection of dexamethasone showed no statistical differences. The outcome was consistent with the research result obtained by Jia et al (2019) [ 8 ]. The further analysis of pain and the incidence of adverse reactions among patients after the treatment by the two methods revealed that the VAS value in the retroauricular group decreased more remarkably than that in the tympanic group ( P < 0.01), and pain VAS score was obviously lower than that in tympanic group ( P < 0.001).…”

Section: Discussionsupporting

confidence: 93%

“…At the early stage of diabetes, minor damage to peripheral organs and dysfunction of the auditory center and peripheral nervous system may occur [ 7 ]. In some studies, it is pointed out that 16% of SHL patients suffer from combined diabetes [ 8 ]. The treatment of SHL patients with diabetes by glucocorticoid causes an increase in glyconeogenesis, the reduction in peripheral glucose utilization, and the aggravation of diabetes [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Mesotympanum Injection and Posterior Auricular Injection in Sudden Hearing Loss of Diabetes Patients

Liu

Wang

Xing

2022

BioMed Research International

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The efficacy of tympanum injection and posterior auricular injection in diabetes with sudden hearing loss (SHL) was analyzed. A mobile terminal-based portable pure tone audiometry system and its processing method were established. Based on mobile terminals, a portable pure tone audiometry system including an Android system, pure sound signal generation, pure tone hearing threshold, and client module was established. A masking model and self-adaptive algorithm were used to detect and reduce noise. Besides, the performance of the portable pure tone audiometry system was detected. A total of 46 diabetes patients with SHL diagnosed at the otolaryngology department in BeiChen Hospital between August 2019 and November 2021 were selected as the research objects and randomly divided into the retroauricular group (posterior auricular injection) and the tympanic group (tympanum injection). Each group included 23 cases. All patients received pure tone audiometry (PTA) before and after the treatment. The changes in fasting blood glucose (FPG), 2h postprandial blood glucose (2hPG), and glycosylated hemoglobin (HbA1c) of the patients were monitored before and after the treatment. Besides, tinnitus loudness visual analog scale (VAS), pain VAS, efficacy, and the incidence of adverse reactions of the patients in two groups were compared. The results indicated that the hear threshold error detected by the medical audiometer and a portable pure tone audiometry system was within 2dB. Before the optimization, there was an error of about 10dB between the hear thresholds detected by the self-adaptive algorithm and a medical audiometer. After the treatment, the hear threshold and average PTA of the patients in the retroauricular and the tympanic groups under different frequencies were both reduced compared with those before the treatment ( P < 0.05 ). The tinnitus VAS score in the retroauricular group was decreased more notably than that in tympanic group ( P < 0.01 ), and the pain VAS score was much lower than that in the tympanic group ( P < 0.001 ). The comparison of FPG, 2hPG, HbA1c, the proportions of cured, significantly effective, effective, ineffective patients, and the total effective rate in the patients in the retroauricular and the tympanic groups before and after the treatment all showed no statistical differences ( P > 0.05 ). The incidence of adverse reactions in tympanic group after the treatment was dramatically higher than that in retroauricular group ( P < 0.001 ). The above results demonstrated that posterior auricular injection showed potential application values in the treatment of SHL with diabetes and established a portable pure tone audiometry system as well as its noise processing method.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Efficacy of Mesotympanum Injection and Posterior Auricular Injection in Sudden Hearing Loss of Diabetes Patients

Liu

Wang

Xing

2022

BioMed Research International

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“…After assessing the remaining 99 full-text articles, 41 studies were excluded for the following reasons: foreign language (n = 3), case reports (n = 3), review or meta-analysis (n = 10), and no mention of complications (n = 25). Finally, 58 studies 1-5,9-61 were included in the systemic review and meta-analysis including 25 randomized controlled trials, 10 prospective studies, and 22 retrospective case-controlled studies ( Table 1 ). A total of 2824 patients served as participants in the meta-analysis wherein 2567 received ITSI via TC (54 articles) and 257 received ITSI via VT (4 articles).…”

Section: Resultsmentioning

confidence: 99%

Tympanic Membrane Perforation After Intratympanic Steroid Injection: A Systematic Review and Meta‐analysis

Kim

Lee

et al. 2021

Otolaryngol.--head neck surg.

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Objective We investigated the incidence of tympanic membrane (TM) perforations induced after intratympanic steroid injection (ITSI) in patients with sudden sensorineural hearing loss (SSNHL) through a systematic review and meta-analysis. Data Sources PubMed, Embase, and MEDLINE. Review Methods Primary database searches were performed, and 1901 records were identified. After removal of 1802 articles through abstract screening, the remaining 99 full-text journals were assessed for eligibility to be included in the study. Fifty-eight studies that used either ventilation tubing (VT) or tympanocentesis (TC) for ITSI were selected for analysis. The subjects were divided into VT and TC groups. The rate of TM perforation after ITSI in 2 groups, sites of ITSI, needle gauge, and influence on residual hearing were investigated. Results The cohorts comprised patients who underwent VT (n = 257, 9.6%) and TC (n = 2415, 90.4%). The proportion of TM perforation after ITSI in each group was 0.073 (95% CI, 0.0469-0.1113) and 0.010 (95% CI, 0.0045-0.0215), respectively, which suggested that the VT group showed a significantly higher TM perforation rate than the TC group ( P < .001). In the subgroup analyses, there was no significant difference in the odds ratio for the rate of TM perforation according to the injection site and needle gauge for TC. The proportion of surgical repair showed no significant difference between the 2 groups. Conclusion ITSI via VT may have a significantly higher risk of TM perforation than ITSI via TC, although those are relatively small overall. ITSI should be performed in the direction to minimize possible adverse effects.

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“…Reports have suggested to withhold batroxobin use if the brinogen is lowered below 80 mg/dL. For brinogen above 400 mg/dL, a batroxobin dose of 20 units per 250 mL saline has been used 50 . De brinogenation using batroxobin in addition to steroid therapy improved hearing as per the case report published by Narita et.…”

Section: Discussionmentioning

confidence: 99%

Association of Fibrinogen Levels with Sudden Sensorineural Hearing Loss Incidence and Prognosis: a Meta-Analysis

Bhattarai

Tharu

Sunar

et al. 2023

Preprint

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Objective This meta-analysis aimed to obtain the pooled estimate of fibrinogen levels in SSNHL cases and investigate its association with patient prognosis and recovery. Data sources We searched the databases PubMed, medRxiv, and Google Scholar for all relevant literature published until August 1, 2022. Review methods The primary objective of the meta-analysis was to assess the association of fibrinogen with the risk of SSNHL and recovery. The search results were screened and selected for review on the basis of eligibility criteria. SSNHL patients were defined as cases and healthy individuals as controls. Data on the level of fibrinogen in SSNHL and controls, as well as recovered and the non-recovered group were subjected to a meta-analysis on Review Manager Version 5.4.1 using a random and fixed-effects model. The pooled estimate was expressed as standardized mean difference (SMD) and forest plots were generated for interpretation Results Fourteen studies with a total of 2,077 participants fulfilled the eligibility. The overall risk of bias was moderate. The blood level of fibrinogen was significantly higher in SSNHL patients as compared to controls [SMD = 0.35; 95% CI = 0.04–0.67; p = 0.03]. Likewise, the recovered group had significantly lower fibrinogen prior to treatment as compared to the non-recovered group [SMD= -0.36; 95% CI= -0.58 to -0.14; p = 0.001]. Conclusion Higher fibrinogen levels were observed in SSNHL patients as compared to controls. Recovered patients had a lower fibrinogen level.

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Efficacy of intratympanic corticosteroid, intravenous batroxobin and combined treatment for sudden sensorineural hearing loss with type-2 diabetes

Cited by 9 publications

References 18 publications

Efficacy of Mesotympanum Injection and Posterior Auricular Injection in Sudden Hearing Loss of Diabetes Patients

Efficacy of Mesotympanum Injection and Posterior Auricular Injection in Sudden Hearing Loss of Diabetes Patients

Tympanic Membrane Perforation After Intratympanic Steroid Injection: A Systematic Review and Meta‐analysis

Association of Fibrinogen Levels with Sudden Sensorineural Hearing Loss Incidence and Prognosis: a Meta-Analysis

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