Efficacy of interferon α‐2b and lamivudine combination treatment in comparison to interferon α‐2b alone in chronic delta hepatitis: A randomized trial

Abstract

Interferon and lamivudine in combination is an encouraging treatment method and may be superior to IFN alone in chronic delta hepatitis.

Treatment of chronic hepatitis D: New advances, old challenges

“…More recently, a few small-size studies investigated the efficacy of standard IFN␣ alone or in combination with ribavirin or lamivudine. In contrast with the results obtained in chronic hepatitis C, the addition of ribavirin failed to show any beneficial effects, 21,22 whereas combination with lamivudine was of limited benefit 23 (Fig. 1).…”

Diagnosis, management and treatment of hepatitis delta virus infection: Turkey 2017 Clinical Practice Guidelines

“…If necessary, PegIFN dose adjustment should be considered. Several cases reported in the literature that interferon alpha treatment improved liver histology in patients with compensated cirrhosis (46). Notably, in the HIDIT-2 Study, virological response rates in cirrhotic patients were similar to non-cirrhotic patients.…”

“…The combination treatments performed so far have not been shown as more effective than interferon treatment alone (39,(41)(42)(43)(44)46). However, with new treatments currently under investigation in phase 2 studies combination treatment may become a viable option (47).…”

Management of HBV, HCV, and HDV coinfection

“…A study reported superiority of LMV/IFN-α combination therapy over IFN-α alone at the end of therapy, but the difference in SVR was not statistically signifi cant [59]. Recently, Yurdaydin et al [60••] compared the efficacy of 1-year treatment with IFN-α or LMV alone versus combination therapy with LMV-IFN-α.…”