Efficacy of high-intensity interval- or continuous aerobic-training on insulin resistance and muscle function in adults with metabolic syndrome: a clinical trial

Gallo‐Villegas, Jaime; Castro-Valencia, Leonardo A.; Pérez, Laura; Restrepo, Daniel Isaza; Guerrero, Óscar Eduardo Gualdrón; Cardona, S Alvaro; Sánchez, Yeliana L; Yepes-Calderón, Manuela; Valbuena, Luis; Peña, Miguel Gil de la; Milán, Andrés F.; Trillos-Almanza, Maria Camila; Granados, Sergio; Aristizábal, Juan Carlos; Estrada-Castrillón, Mauricio; Narváez-Sánchez, Raúl; Osório, Jorge; Aguirre–Acevedo, Daniel Camilo; Calderón, Juan C.

doi:10.1007/s00421-021-04835-w

Cited by 13 publications

(16 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The uniqueness of this study, however, lay in including HIIT, alone or in combination with VLCHF diet, into consideration. An exercise intervention program proved to be effective in the treatment of insulin resistance in individuals with overweight/obesity ( 34 ), metabolic syndrome ( 35 ) or type 2 diabetes, i.e., reduces fasting insulin, HOMA-IR, fasting blood sugar, HbA1c, and body mass index ( 36 ). However, we did not show any or additional effect of HIIT on these variables after 12 weeks.…”

Section: Discussionmentioning

confidence: 99%

Very Low-Carbohydrate High-Fat Diet Improves Risk Markers for Cardiometabolic Health More Than Exercise in Men and Women With Overfat Constitution: Secondary Analysis of a Randomized Controlled Clinical Trial

et al. 2022

View full text Add to dashboard Cite

PurposeThis randomized controlled parallel-group study examined the effects of a very low-carbohydrate high-fat (VLCHF) diet and high-intensity interval training (HIIT) program over 12-weeks on cardiometabolic risk factors in individuals with overfat constitution.MethodsNinety-one participants out of 109 completed the study. The participants were randomly allocated to the HIIT (N = 22), VLCHF (N = 25), VLCHF+HIIT (N = 25), or control (N = 19) groups for 12 weeks. Fasting plasma samples were collected before the intervention and after 4 and 12 weeks. The analyzed outcomes included complete blood count, glucose, insulin, glycated hemoglobin, triglycerides (TG), cholesterol, high- and low-density lipoprotein (HDL-C and LDL-C), lipoprotein(a), adiponectin (Adpn), leptin (Lep), tumor necrosis factor α (TNF-α), other interleukins (hs-IL-6, IL-1β, and IL-10), and IL-1RA. The homeostasis model assessment of insulin resistance (HOMA-IR), Adpn/Lep ratio, TG/HDL-C ratio, and TyG index were calculated and analyzed. Blood pressure was measured before the intervention, after 4, 8, and 12 weeks (ClinicalTrials.gov: NCT03934476).ResultsAbsolute changes in HOMA-IR, Adpn/Lep ratio, LDL-C, and diastolic blood pressure after 12 weeks differed by study groups (p < 0.05). The most pronounced changes were revealed in the VLCHF (ΔM [95% CI]; HOMA-IR: −0.75 [−1.13; −0.55]; Adpn/Lep: 9.34 [6.33; 37.39]; LDL-C: 0.06 [−0.12; 0.50] mmol/l) and VLCHF+HIIT (HOMA-IR: −0.44 [−1.14; 0.12]; Adpn/Lep: 4.26 [2.24; 13.16]; LDL-C: 0.25 [−0.04; 0.50] mmol/l) groups.ConclusionsA 12-week VLCHF diet intervention in individuals with overfat constitution is effective for favorable changes in HOMA-IR (compared to HIIT), Adpn/Lep ratio, and diastolic blood pressure. HIIT, or HIIT combined with the VLCHF diet, had no additional benefits for the analyzed variables. No adverse side effects were observed.

show abstract

Section: Discussionmentioning

confidence: 99%

Very Low-Carbohydrate High-Fat Diet Improves Risk Markers for Cardiometabolic Health More Than Exercise in Men and Women With Overfat Constitution: Secondary Analysis of a Randomized Controlled Clinical Trial

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Physical activity was recorded with the Global Physical Activity Questionnaire (GPAQ) [ 44 ]. Cardiorespiratory fitness was assessed through an incremental treadmill ergospirometry test with an open circuit spirometer Oxycon Delta by Jaeger ® (VIASYS Health care GmbH, Pullach, Germany), as previously described [ 45 ]. Waist circumference was measured with fiberglass anthropometric tape at the midpoint between the lower edge of the rib cage and the iliac crest, according to the World Health Organization recommendations [ 46 ], and IR was estimated with the HOMA-IR [ 5 ].…”

Section: Methodsmentioning

confidence: 99%

“…The intramuscular lipid content was evaluated in the right vastus lateralis muscle (VLM) due to its association with the development of metabolic diseases in humans [ 51 , 52 ], using 1 H-MRS and a flexible coil [ 45 ], following international recommendations [ 53 ].…”

Section: Methodsmentioning

confidence: 99%

“…Spectra were acquired on a Magnetom Skyra magnet with a Flex large 4-channels, 3T receive only, 516 × 224 mm, coil interface and the SyngoMR D13 program (Siemens Healthcare, Erlangen, Germany) as previously reported [5,45,54]. The spectra were processed with jMRUI [55] v5.2 software (http://www.jmrui.eu, accessed on 1 February 2020).…”

Section: Quantification Of Intramuscular Lipidsmentioning

confidence: 99%

See 1 more Smart Citation

Serum Levels of Myonectin Are Lower in Adults with Metabolic Syndrome and Are Negatively Correlated with Android Fat Mass

Petro

Fragozo-Ramos

Milán

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

Myonectin has shown beneficial effects on lipid regulation in murine models; therefore, it may have implications in the pathophysiology of metabolic syndrome (MS). We evaluated the relationship between serum myonectin and serum lipids, global and regional fat mass, intramuscular lipid content, and insulin resistance (IR) in adults with metabolic risk factors. This was a cross-sectional study in sedentary adults who were diagnosed with MS or without MS (NMS). Serum myonectin was quantified by enzyme-linked immunosorbent assay, lipid profile by conventional techniques, and free fatty acids (FFA) by gas chromatography. Body composition was assessed by dual-energy X-ray absorptiometry and intramuscular lipid content through proton nuclear magnetic resonance spectroscopy in the right vastus lateralis muscle. IR was estimated with the homeostatic model assessment (HOMA-IR). The MS (n = 61) and NMS (n = 29) groups were comparable in age (median (interquartile range): 51.0 (46.0–56.0) vs. 53.0 (45.5–57.5) years, p > 0.05) and sex (70.5% men vs. 72.4% women). MS subjects had lower serum levels of myonectin than NMS subjects (1.08 (0.87–1.35) vs. 1.09 (0.93–4.05) ng·mL−1, p < 0.05). Multiple linear regression models adjusted for age, sex, fat mass index and lean mass index showed that serum myonectin was negatively correlated with the android/gynoid fat mass ratio (R2 = 0.48, p < 0.01), but not with the lipid profile, FFA, intramuscular lipid content or HOMA-IR. In conclusion, serum myonectin is lower in subjects with MS. Myonectin negatively correlates with a component relevant to the pathophysiology of MS, such as the android/gynoid fat mass ratio, but not with other components such as FFA, intramuscular fat or IR.

show abstract

“…The therapeutic benefits of exercise training in patients with diabetes and metabolic syndrome is well-known (Colberg et al, 2010;American Diabetes Association, 2014;Gallo-Villegas et al, 2022). HIIT is a time-efficient alternative to moderate-intensity continuous training to improve various aspects of health in patients (Tjønna et al, 2008;Jung et al, 2015;Mendes et al, 2019) and in animal experiments (Chavanelle et al, 2017;Wang et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Effects of two workload-matched high intensity interval training protocols on regulatory factors associated with mitochondrial biogenesis in the soleus muscle of diabetic rats

et al. 2022

View full text Add to dashboard Cite

Aims: High intensity interval training (HIIT) improves mitochondrial characteristics. This study compared the impact of two workload-matched high intensity interval training (HIIT) protocols with different work:recovery ratios on regulatory factors related to mitochondrial biogenesis in the soleus muscle of diabetic rats.Materials and methods: Twenty-four Wistar rats were randomly divided into four equal-sized groups: non-diabetic control, diabetic control (DC), diabetic with long recovery exercise [4–5 × 2-min running at 80%–90% of the maximum speed reached with 2-min of recovery at 40% of the maximum speed reached (DHIIT1:1)], and diabetic with short recovery exercise (5–6 × 2-min running at 80%–90% of the maximum speed reached with 1-min of recovery at 30% of the maximum speed reached [DHIIT2:1]). Both HIIT protocols were completed five times/week for 4 weeks while maintaining equal running distances in each session.Results: Gene and protein expressions of PGC-1α, p53, and citrate synthase of the muscles increased significantly following DHIIT1:1 and DHIIT2:1 compared to DC (p ˂ 0.05). Most parameters, except for PGC-1α protein (p = 0.597), were significantly higher in DHIIT2:1 than in DHIIT1:1 (p ˂ 0.05). Both DHIIT groups showed significant increases in maximum speed with larger increases in DHIIT2:1 compared with DHIIT1:1.Conclusion: Our findings indicate that both HIIT protocols can potently up-regulate gene and protein expression of PGC-1α, p53, and CS. However, DHIIT2:1 has superior effects compared with DHIIT1:1 in improving mitochondrial adaptive responses in diabetic rats.

show abstract

Efficacy of high-intensity interval- or continuous aerobic-training on insulin resistance and muscle function in adults with metabolic syndrome: a clinical trial

Cited by 13 publications

References 55 publications

Very Low-Carbohydrate High-Fat Diet Improves Risk Markers for Cardiometabolic Health More Than Exercise in Men and Women With Overfat Constitution: Secondary Analysis of a Randomized Controlled Clinical Trial

Very Low-Carbohydrate High-Fat Diet Improves Risk Markers for Cardiometabolic Health More Than Exercise in Men and Women With Overfat Constitution: Secondary Analysis of a Randomized Controlled Clinical Trial

Serum Levels of Myonectin Are Lower in Adults with Metabolic Syndrome and Are Negatively Correlated with Android Fat Mass

Effects of two workload-matched high intensity interval training protocols on regulatory factors associated with mitochondrial biogenesis in the soleus muscle of diabetic rats

Contact Info

Product

Resources

About