2018
DOI: 10.4103/jrms.jrms_949_17
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Efficacy of herbal combination of sedge, saffron, and Astragalus honey on major neurocognitive disorder

Abstract: Background:Major neurocognitive disorder (MCD) is an acquired progressive decline in cognitive abilities that causes a drop in specific acquired performance compared to former performances. We tried to investigate the efficacy of herbal combination of sedge, saffron, and Astragalus honey on cognitive and depression score of patients with MCD.Materials and Methods:It was a randomized double-blind clinical trial conducted on sixty patients with MCD, who referred to the geriatric psychiatry clinic of Isfahan Univ… Show more

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Cited by 7 publications
(5 citation statements)
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“…A total of 7 publications with 368 patients were eligible for inclusion, and the intervention duration varied from 8 to 48 weeks (Abbaszadeh‐Mashkani et al, 2020; Akhondzadeh, Sabet, et al, 2010; Akhondzadeh, Shafiee Sabet, et al, 2010; Akouchekian et al, 2018; Farokhnia et al, 2014; Moazen‐Zadeh et al, 2018; Tsolaki et al, 2016). Six studies were conducted in Iran and one in Greece.…”
Section: Resultsmentioning
confidence: 99%
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“…A total of 7 publications with 368 patients were eligible for inclusion, and the intervention duration varied from 8 to 48 weeks (Abbaszadeh‐Mashkani et al, 2020; Akhondzadeh, Sabet, et al, 2010; Akhondzadeh, Shafiee Sabet, et al, 2010; Akouchekian et al, 2018; Farokhnia et al, 2014; Moazen‐Zadeh et al, 2018; Tsolaki et al, 2016). Six studies were conducted in Iran and one in Greece.…”
Section: Resultsmentioning
confidence: 99%
“…For placebo‐controlled studies (Abedimanesh et al, 2017; Agha‐Hosseini et al, 2008; Akhondzadeh et al, 2005; Akhondzadeh et al, 2020; Akouchekian et al, 2018; Ghaderi et al, 2019; Jalali & Hashemi, 2018; Kashani et al, 2018; Kell et al, 2017; Khalatbari‐Mohseni et al, 2019; Lopresti et al, 2018, 2020; Lopresti & Drummond, 2017; Mazidi et al, 2016; Milajerdi et al, 2018; Moazen‐Zadeh et al, 2018; Moshiri et al, 2006; Salek et al, 2021; Tabeshpour et al, 2017; Tajaddini et al, 2021; Tsolaki et al, 2016), the pooled analysis suggested that saffron showed a greater improvement in depression symptoms when compared with placebo, with an average net change in scores ranging from −8.96 to 1.13 and 12 of 22 trials reaching statistical significance (Figure 2a). After meta‐analysis, the overall effect size of saffron was −4.26 (95% CI: −5.76, −2.77), and high heterogeneity with an I 2 of 85.3% was observed.…”
Section: Resultsmentioning
confidence: 99%
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“…The results indicated that the combination could be useful to improve the cognitive and depression score. However, the extract used was not characterized, and the preparation method was not indicated [ 134 ]. The traditional Iranian herbal medicine, Davaie Loban, composed of C. rotundus , Zingiber officinale , Acorus calamus , Piper nigrum , and Boswellia carterii has also been tested against AD.…”
Section: Health-promoting Effects: Data From Clinical Findingsmentioning
confidence: 99%