Efficacy of heat-killed and formalin-killed vaccines against<i>Tilapia tilapinevirus</i>in juvenile Nile tilapia (<i>Oreochromis niloticus</i>)

Mai, Thao Thu; Kayansamruaj, Pattanapon; Taengphu, S; Senapin, Saengchan; Costa, Janina Z.; Del-Pozo, Jorge; Thompson, Kim D.; Rodkhum, Channarong; Dong, Ha Thanh

doi:10.1101/2021.06.03.447010

Cited by 3 publications

(14 citation statements)

References 66 publications

(107 reference statements)

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“…MHC class Iα gene, 91 and two MHC‐II molecules, MHC‐IIa and MHC‐IIb have been described for Nile tilapia 92 . Both CD4 and CD8 genes have also been identified in tilapia 93,94 . The CD8 + T cells (also referred to as cytotoxic T lymphocytes or CTLs) are an important immune defence against intracellular pathogens (viruses and bacteria) or tumour cells.…”

Section: Immune System In Tilapiamentioning

confidence: 99%

“…Although its function remains unclear, IgT plays a major role in mucosal immunity and is found predominantly in the mucus on mucosal surfaces of gills, skin and intestines 99 . IgM is frequently used as a measure of systemic antibody responses, while IgT is often used as a measure of a mucosal antibody response, including in tilapia 94,96,100 …”

Section: Immune System In Tilapiamentioning

confidence: 99%

“…Regarding viral vaccines, only one ISKNV vaccine has been developed and commercialized (AQUAVAC® MSD Animal Health) so far. Besides ISKNV, recent studies have shown the effectiveness of vaccines against TiLV in tilapia 94,178,179 . Different types of vaccine are currently under development for TiLV, such as live‐attenuated, inactivated, DNA and subunit vaccines 94,178,179 .…”

Section: Vaccinationmentioning

confidence: 99%

“…Besides ISKNV, recent studies have shown the effectiveness of vaccines against TiLV in tilapia 94,178,179 . Different types of vaccine are currently under development for TiLV, such as live‐attenuated, inactivated, DNA and subunit vaccines 94,178,179 . Evidence suggests tilapia that have survived an infection by TiLV develop antibody responses and have protection against subsequent TiLV infections, thus indicating the potential of an effective vaccine to protect tilapia from TiLV disease 180,181 .…”

Section: Vaccinationmentioning

confidence: 99%

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Strategies to enhance tilapia immunity to improve their health in aquaculture

Wang

Thompson

Wangkahart

et al. 2022

Reviews in Aquaculture

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Various emerging and re-emerging diseases, such as streptococcosis, tilapia lake virus disease and infectious spleen and kidney necrosis virus disease, have had a significant economic impact on the tilapia industry over the last decade. These diseases have resulted in high levels of morbidity and mortality, production losses and trade restrictions. In the absence of effective husbandry management, disease prevention strategies and appropriate biosecurity measures, infectious diseases will continue to challenge the sustainability of global tilapia aquaculture. Strategies used to reduce the impact of disease include feeding probiotic and prebiotic supplements to enhance tilapia health and to modulate the fish's gut microbiota to improve gut health. Herbal medicines and immunostimulants are also used to enhance immunity to disease, while vaccines are available, or are under development, for a number of economically important pathogens affecting tilapia culture. This review provides an overview of the benefits of enhancing the immune response of tilapia to improve their health, and in turn reduce the levels of pathogens within tilapia farming systems.

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Section: Immune System In Tilapiamentioning

confidence: 99%

Section: Immune System In Tilapiamentioning

confidence: 99%

Section: Vaccinationmentioning

confidence: 99%

Section: Vaccinationmentioning

confidence: 99%

See 2 more Smart Citations

Strategies to enhance tilapia immunity to improve their health in aquaculture

Wang

Thompson

Wangkahart

et al. 2022

Reviews in Aquaculture

View full text Add to dashboard Cite

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“…Tilapia lake virus (TiLV) has existed in tilapia farms since its first identification in Israel in 2013 (Eyngor et al., 2014). Vaccination or medication for TiLV is still under development for effective disease prevention or therapies (Mai et al., 2021; Zeng, Wang, Chen, et al., 2021; Zeng, Wang, Hu, et al., 2021). Probiotics have been promoted as one of the most promising dietary interventions to alleviate disease transmission in aquaculture by elevating the defence systems in farmed fish/shellfish (Hoseinifar et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Assessing the effect of probiotics on tilapia lake virus‐infected tilapia: Transmission and immune response

Yang

Yamkasem

Surachetpong

et al. 2022

Journal of Fish Diseases

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Probiotics have been used to alleviate disease transmission in aquaculture. However, there are limited studies on probiotic use in modulating tilapia lake virus (TiLV). We assessed commercially available probiotic supplements used in TiLV‐infected tilapia and performed mortality and cohabitation assays. We developed a mechanistic approach to predict dose–response interactions of probiotic effects on mortality and immune gene response. We used a susceptible–infected–mortality disease model to assess key epidemiological parameters such as transmission rate and basic reproduction number (R0) based on our viral load dynamic data. We found that the most marked benefits of probiotics are significantly associated with immune system enhancements (~30%) and reductions in disease transmission (~80%) and R0 (~70%) in tilapia populations, resulting in a higher tolerance of farming densities (~400 fold) in aquaculture. These findings provide early insights as to how probiotic use‐related factors may influence TiLV transmission and the immune responses in TiLV‐infected tilapia. Our study facilitates understanding the mode of action of probiotics in disease containment and predicting better probiotic dosages in diet and supplements to achieve the optimal culturing conditions. Overall, our analysis assures that further study of rationally designed and targeted probiotics, or mechanistic modelling is warranted on the basis of promising early data of this approach.

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