Efficacy of fractionated microneedle radiofrequency with and without adding subcision for the treatment of atrophic facial acne scars: A randomized split‐face clinical study

Faghihi, Gita; Poostiyan, Nazila; Asilian, Ali; Abtahi‐Naeini, Bahareh; Shahbazi, Masoom; Iraji, Fariba; Naeini, Farahnaz Fatemi; Nilforoushzadeh, Mohammad Ali

doi:10.1111/jocd.12346

Cited by 36 publications

(35 citation statements)

References 25 publications

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“…Faghihi et al have performed a split face study comparing the efficacy of only MFR and combination of MFR and subcision in 25 patients with facial atrophic acne scar. They have found a significant improvement in the combination group than in only MFR group . Park et al have performed combined microneedle and sublative fractional radiofrequency in 20 Asian patients with acne scars and reported grade 2 or more clinical improvement according to physicians’ assessment in all patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy of microneedle fractional radiofrequency in Turkish patients with atrophic facial acne scars

Başkan

Belli

2018

J of Cosmetic Dermatology

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Summary Background Scarring is an undesirable and severe complication of acne resulting in loss of self‐esteem in young people. Although microneedle fractional radiofrequency (MFR) system has emerged as a good option to treat acne scars in recent years, it was examined in a few studies which were commonly from Asian countries. Aims We sought to evaluate the efficacy of MFR in Turkish patients with facial acne scars. Methods Nine patients with atrophic facial acne scars treated with MFR device were included in the study. The number of treatment sessions was varied from one to five (median three) with 4‐week intervals. Demographic and basal clinical features were recorded. Efficacy of the device was evaluated by the physicians’ global assessment and patients’ self‐assessment scales 4 weeks after the last treatment session. Results Of nine patients, two were male and seven were female (mean age, 31.33 years). Two patients had mild, four had moderate, and three had severe facial acne scars. Mean acne scar age was 13.22 ± 8.79 years. According to the predominant scar subtype, three patients had V‐shaped, three had U‐shaped, and three had M‐shaped atrophic acne scars. A clinical improvement of >25% has been reported in seven patients (77.7%) and eight patients (88.9%) by the physicians and patients, respectively. U‐shaped atrophic acne scars responded better to the treatment than the other types, as statistically nonsignificant. There were no severe side effects. Conclusions Microneedle fractional radiofrequency system showed a quite good efficacy and safety in the treatment of atrophic facial acne scars (Department of Dermato‐Cosmetology, Uludag University Medical School).

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Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy of microneedle fractional radiofrequency in Turkish patients with atrophic facial acne scars

Başkan

Belli

2018

J of Cosmetic Dermatology

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“…Subcision is an important procedure to include in minimally invasive multimodality regimens because it releases tethering of the epidermis to the dermis that is present in many atrophic scars, especially rolling scars, and enhances neocollagenesis. It has been combined successfully with needling, fractional CO 2 laser, and microneedling radiofrequency to enhance their efficacy in treating atrophic scars …”

Section: Discussionmentioning

confidence: 99%

“…It has been combined successfully with needling, fractional CO 2 laser, and microneedling radiofrequency to enhance their efficacy in treating atrophic scars. [7][8][9] Needling enhances neocollagenesis which continues for a few months after the procedure 10 ; therefore, there is evidence that needling provides more than a transient benefit for acne scars. 11 The number of melanocytes is not affected as there is no epidermal damage, and hence, needling can be used safely in darker skinned individuals.…”

Section: Discussionmentioning

confidence: 99%

Combination therapy using subcision, needling, and platelet‐rich plasma in the management of grade 4 atrophic acne scars: A pilot study

Bhargava

Kroumpouzos

Varma

et al. 2019

J of Cosmetic Dermatology

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Summary Background Multimodality therapies including minimally invasive modalities are increasingly used in atrophic scarring. Objective To evaluate the role of platelet‐rich plasma (PRP) as adjunctive therapy to a combined subcision and needling treatment in severe (grade 4) atrophic acne scarring. Methods A total of 30 patients with grade 4 acne scars were randomly divided into two groups, 15 patients each: Group A underwent three sequential treatments of subcision and needling while Group B, three sequential treatments of subcision, needling, and topical application of PRP that were performed at 3‐week intervals. Scar grading was assessed 3 months following the final session. Participant's assessment of treatment response was registered. Results Scar improvement ≥50% was reported significantly more often by Group B than Group A patients (P = 0.025). Regarding physician‐based assessment of scar grading post‐therapy (number of patients with two grades improvement vs one grade or no improvement), there was a trend toward more improvement in Group B (P = 0.195). Physician's evaluation of acne scar improvement correlated with the patient's assessment of improvement: 60% of Group A and 66.6% of Group B patients appreciated an improvement of 25%‐49% and 50%‐74%, respectively. Mean duration of postprocedure erythema/edema was shorter among Group B than Group A patients (16.1 vs 32.9 hours, respectively). Overall, substantial improvement was noticed in rolling and boxcar scars with only a mild change in icepick scars. Conclusion Platelet‐rich plasma appears to add to the improvement of grade 4 atrophic acne scars when combined with needling and subcision. These findings require further evaluation by future studies.

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“…In a recent study, combination of hydrogel scaffold with mouse adult DPCs and epidermal cells enhances de novo hair follicle formation in mice model. Some of the natural and individual biomaterials used as scaffolds for the ingenious treatment of hair loss include PRP [6,63,64]. The components of PRP include the PDGF, the FGF, and the VEGF, which can induce proliferation, differentiation, and maintenance of the hair inductivity in DPCs [65].…”

Section: Tissue Engineering Strategies For Human Hair Follicle Regenementioning

confidence: 99%

Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods

Taghiabadi

Nilforoushzadeh

Aghdami

2020

Skin Pharmacol Physiol

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The dermal papilla comprises mesenchymal cells in hair follicles, which play the main role in regulating hair growth. Maintaining the potential hair inductivity of dermal papilla cells (DPCs) and dermal sheath cells during cell culture is the main factor in in vitro morphogenesis and regeneration of hair follicles. Using common methods for the cultivation of human dermal papilla reduces the maintenance requirements of the inductive capacity of the dermal papilla and the expression of specific dermal papilla biomarkers. Optimizing culture conditions is therefore crucial for DPCs. Moreover, exosomes appear to play a key role in regulating the hair follicle growth through a paracrine mechanism and provide a functional method for treating hair loss. The present review investigated the biology of DPCs, the molecular and cell signaling mechanisms contributing to hair follicle growth in humans, the properties of the dermal papilla, and the effective techniques in maintaining hair inductivity in DPC cultures in humans as well as hair follicle bioengineering.

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Efficacy of fractionated microneedle radiofrequency with and without adding subcision for the treatment of atrophic facial acne scars: A randomized split‐face clinical study

Cited by 36 publications

References 25 publications

Evaluation of the efficacy of microneedle fractional radiofrequency in Turkish patients with atrophic facial acne scars

Evaluation of the efficacy of microneedle fractional radiofrequency in Turkish patients with atrophic facial acne scars

Combination therapy using subcision, needling, and platelet‐rich plasma in the management of grade 4 atrophic acne scars: A pilot study

Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods

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