Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods

Taghiabadi, Ehsan; Nilforoushzadeh, Mohammad Ali; Aghdami, Nasser

doi:10.1159/000510152

Cited by 52 publications

(53 citation statements)

References 74 publications

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“…Gentile showed the HD-AFSCs show positivity for CD44, CD100, CD200, and S100A4 which represent the early progeny of stem cells and help in the expression with the growth of keratinocytes [ 34 ]. MSC cells express Wnt/ β -catenin signalling molecules which have been shown as a fundamental factor that augments hair growth [ 36 , 37 ]. There also occurs expression of VEGF, TGF- β , IGF-1, IGFBP-1to-6, M-CSF, M-CSFR, PDGF, PDGFR- β /- α 64, PGE2, and PGF2 α which all contributes in the hair regrowth [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Association between Mesenchymal Stem Cells and COVID-19 Therapy: Systematic Review and Current Trends

Javed

Karki

Sami

et al. 2022

BioMed Research International

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Background. The novel coronavirus first emerged in Wuhan, China, and quickly spread across the globe, spanning various countries and resulting in a worldwide pandemic by the end of December 2019. Given the current advances in treatments available for COVID-19, mesenchymal stem cell (MSC) therapy seems to be a prospective option for management of ARDS observed in COVID-19 patients. This present study is aimed at exploring the therapeutic potential and safety of using MSC obtained by isolation from health cord tissues in the treatment of patients with COVID-19. Methods. A systematic search was done based on the guidelines of the PRISMA 2020 statement. A literature search was executed using controlled vocabulary and indexing of trials to evaluate all the relevant studies involving the use of medical subject headings (MeSH) in electronic databases like PubMed, Embase, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and clinicaltrials.gov up to 31 December 2021. The protocol was registered in the PROSPERO register with ID CRD42022301666. Findings. After screening finally, 22 remaining articles were included in this systematic review. The studies revealed that MSC exosomes are found to be superior to MSC alone in terms of safety owing to being smaller with a lesser immunological response which leads to free movement in blood capillaries without clumping and also cannot further divide, thus reducing the oncogenic potential of MSC-derived exosomes as compared to MSC only. The studies demonstrated that the lungs healed with the use of exosomes compared to how they presented initially at the hospital. MSCs are found to increase the angiogenesis process and alveolar reepithelization, reducing markers like TNF alpha, TGF beta, and COL I and III, reducing the growth of myofibroblasts and increasing survivability of endothelium leading to attenuated pulmonary fibrosis and even reversing them. Interpretation. We can conclude that the use of mesenchymal stem cells or their derived exosomes is safe and well-tolerated in patients with COVID-19. It improves different parameters of oxygenation and helps in the healing of the lungs. The viral load along with different inflammatory cells and biomarkers of inflammation tend to decrease. Chest X-ray, CT scan, and different radiological tools are used to show improvement and reduced ongoing destructive processes.

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Section: Resultsmentioning

confidence: 99%

Association between Mesenchymal Stem Cells and COVID-19 Therapy: Systematic Review and Current Trends

Javed

Karki

Sami

et al. 2022

BioMed Research International

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“…DPCs can interact with other cells in hair follicles and are able to release various cytokines to activate several pathways which control the differentiation of the matrix cells and regulate hair growth and development. 36 With the capability to resist environmental pressure, the matrix cells can also respond more quickly to the regulation of cytokines and signaling pathways and fast differentiate into various structures of the hair follicle, such as outer root sheath cells, internal root sheath cells, keratinocytes.…”

Section: Discussionmentioning

confidence: 99%

Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles and Dermal Papilla Cells

Zhang¹,

Ni²,

Huang³

et al. 2021

CCID

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Background: Oxidative damage has been found in various types of hair loss. As a polyphenolic phytoalexin, resveratrol (RSV) is known as an antioxidant, anti-inflammatory and anti-apoptotic agent.Objective: Thus, we aim to examine the effects of RSV on hair growth. Methods: In vivo C57BL/6 mice were used to evaluate the effects of RSV on hair cycle, hair length, skin thickness, hair follicle diameter, hair cycle score and the percentage of hair cycle stage. Then hair shaft length and hair cycle were evaluated by human hair follicles (HFs) ex vivo. The proliferative activities of human dermal papilla cells (hDPCs) cultured in vitro with RSV were assessed using RTCA. The ability of RSV to protect hDPCs against H 2 O 2 -induced oxidative damage is examined by a ROS assay kit. Results: Topical application of RSV significantly promoted hair growth and stimulated the transition of hair cycle from telogen into the anagen phase on shaved C57BL/6 mice. Ex vivo experiments showed that RSV increased the hair shaft length of HFs and delayed the entry into catagen. In vitro experiments indicated that RSV proliferated hDPCs and prevented hDPCs from oxidative damage caused by H 2 O 2 . Conclusion: RSV can promote hair growth and may be a potential candidate for the treatment of hair loss.

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“…Human DPCs are mesenchymal cells isolated from the hair papilla of healthy scalp hair follicles. In the adult hair follicle, hair papilla plays a key role in controlling hair production and hair growth ( 113 ). PAM treatment at an appropriate concentration and duration was found to arrest cell proliferation and cell cycle of DPCs, which could gradually recover.…”

Section: Treatment Of Skin Disease Using Capmentioning

confidence: 99%

Plasma Dermatology: Skin Therapy Using Cold Atmospheric Plasma

et al. 2022

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Cold atmospheric plasma-based plasma medicine has been expanding the diversity of its specialties. As an emerging branch, plasma dermatology takes advantage of the beneficial complexity of plasma constituents (e.g., reactive oxygen and nitrogen species, UV photons, and electromagnetic emission), technical versatility (e.g., direct irradiation and indirect aqueous treatment), and practical feasibility (e.g., hand-held compact device and clinician-friendly operation). The objective of this comprehensive review is to summarize recent advances in the CAP-dominated skin therapy by broadly covering three aspects. We start with plasma optimisation of intact skin, detailing the effect of CAP on skin lipids, cells, histology, and blood circulation. We then conduct a clinically oriented and thorough dissection of CAP treatment of various skin diseases, focusing on the wound healing, inflammatory disorders, infectious conditions, parasitic infestations, cutaneous malignancies, and alopecia. Finally, we conclude with a brief analysis on the safety aspect of CAP treatment and a proposal on how to mitigate the potential risks. This comprehensive review endeavors to serve as a mini textbook for clinical dermatologists and a practical manual for plasma biotechnologists. Our collective goal is to consolidate plasma dermatology’s lead in modern personalized medicine.

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Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods

Cited by 52 publications

References 74 publications

Association between Mesenchymal Stem Cells and COVID-19 Therapy: Systematic Review and Current Trends

Association between Mesenchymal Stem Cells and COVID-19 Therapy: Systematic Review and Current Trends

Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles and Dermal Papilla Cells

Plasma Dermatology: Skin Therapy Using Cold Atmospheric Plasma

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