Efficacy of fixed daily 20 mg of isotretinoin in moderate to severe scar prone acne

Rasi, Abbas; Behrangi, Elham; Rohaninasab, Masoumeh; Nahad, Zahra Mehr

doi:10.4103/2277-9175.129693

Cited by 22 publications

(9 citation statements)

References 23 publications

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“…investigated the efficacy of low daily dose isotretinoin in moderate to severe acne patients. They found that low-dose isotretinoin was found to be a safe and effective choice for patients with moderate to severe scar prone acne vulgaris[ 17 ] so their results are consistent with our results.…”

Section: Discussionsupporting

confidence: 91%

Comparing the efficacy of low dose and conventional dose of oral isotretinoin in treatment of moderate and severe acne vulgaris

et al. 2017

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Objective:This study was conducted to compare the effect of low-dose isotretinoin with its conventional dose in patients with moderate and severe acne.Methods:This was a clinical trial conducted on 60 male and female patients with moderate and severe acne vulgaris. The patients were divided into two treatment groups: 0.5 mg/kg/day isotretinoin capsule and low-dose isotretinoin capsule (0.25 mg/kg/day). Patients in both groups received 6-month treatment. At the end of the 6th month and 12th month (6 months after the end of the treatment), they were examined again, and their improvement was determined and compared.Findings:The average severity of acne in the two treatment groups did not differ significantly within any of the study periods. The most common side effects were nose dryness in the low-dose group (17%) and hair thinning and loss in the conventional-dose group (33.2%), although all the patients had dry lips.Conclusion:According to the same severity of the acne in two groups in different study periods, as well as fewer side effects and more patients' satisfaction, the low-dose isotretinoin can be considered in the treatment of acne.

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Section: Discussionsupporting

confidence: 91%

Comparing the efficacy of low dose and conventional dose of oral isotretinoin in treatment of moderate and severe acne vulgaris

et al. 2017

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“…Among these 3 groups, patients in group C have developed more side effects than other two groups. The side effects were cheilitis (100%), xerosis (38.10%), dryness of mouth and dry, rough hair (4.76%), dandruff (14.28%), erythema over face and hair loss (4.76%), elevated liver enzyme (9.52%) and elevated serum triglycerides (23.8%) which was similar to previous studies 3,10,[13][14][15][16] .…”

Section: Discussionsupporting

confidence: 88%

Comparative Efficacy of Three Low - dose Isotretinoin Regimens in Treatment of Mild to Moderate Acne Vulgaris on the Face in Tertiary Care Institute

Shah¹,

Gugle²

2020

mvpjms

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Background: Acne is a disease that affects almost 100% of the population. The clinical presentation ranges from comedones, papules, pustules and nodules. Various systemic treatment modalities like oral antibiotics, retinoids, hormonal therapy and corticosteroids, are available with varied benefits and side effects. Aims: To study and compare the efficacy and safety profile of three low dose isotretinoin regimens in the treatment of mild to moderate acne vulgaris. Methods: 75 patients having mild to moderate acne vulgaris were randomized into three different low dose isotretinoin regimens. Each was consisting of 25 patients. Group A was prescribed 5 mg, Group B 10 mg and Group C 20 mg isotretinoin for 4 months. Clinical improvement and side effects were recorded. Results: All regimens showed clinical improvement in 4 months of therapy. Isotretinoin 20 mg was found to be superior in later half of therapy. But isotretinoin 10 mg and 20 mg both were statistically equally efficacious in mild to moderate acne vulgaris. Side effects were higher in Group C as compared to Group A and B. Conclusion: We conclude that all three low dose regimens were efficacious in mild to moderate acne vulgaris. Isotretinoin 10 mg was found to be an effective and safe treatment option in such cases.

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“…And in each tested formula amount of QRS was equal to that of ITT [1:1 ratio of ITT:QRS]. ( Table 4 ) [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Self-Nanoemulsion Loaded with a Combination of Isotretinoin, an Anti-Acne Drug, and Quercetin: Preparation, Optimization, and In Vivo Assessment

2020

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Acne vulgaris is a common skin disease that affects everybody at least once in their lives. The treatment is challenging because the stratum corneum contains rigid corneocytes surrounded by intercellular lamellae that are difficult to bypass. In the present study, we intended to formulate an effective nanoemulsion that could deliver isotretinoin (ITT) with enhanced solubility, permeability, and bioavailability across the skin. ITT can have a serious hepatotoxic effect if given too frequently or erratically. Therefore, to overcome the aforesaid limitation, quercetin (QRS), a hepatoprotective agent, was incorporated into the formulation. Initially, the ITT solubility was determined in various surfactants and cosurfactants to select the essential ingredients to be used in the formulation and to optimize a nanoemulsion that could enhance the solubility and permeability of ITT and its antimicrobial activity against Staphyloccocus aureus, which is the main microorganism responsible for acne vulgaris. The mixture design was applied to study the interactions and optimize the independent variables that could match the prerequisites of selected dependent responses. A formulation containing 0.25 g of rosehip oil, 0.45 g of surfactant (Lauroglycol-90), and 0.3 g of cosurfactant (propylene glycol) was chosen as an optimized desirable formulation. The optimized batch was loaded with QRS and evaluated for in vitro and ex vivo permeation. The in vivo hepatotoxicity was assessed through topical administration. Permeability studies confirmed the enhanced permeation percentage of ITT (52.11 ± 2.85%) and QRS (25.44 ± 3.18%) of the optimized formulation, with an enhanced steady-state flux (Jss). The in vivo studies conducted on experimental animals demonstrated superior hepatoprotective activity of the prepared optimized formulation compared with other formulations of drugs and commercially marketed products. We anticipate that this optimized ITT formulation, followed up with good clinical evaluations, can be a breakthrough in the safe treatment of acne vulgaris.

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Efficacy of fixed daily 20 mg of isotretinoin in moderate to severe scar prone acne

Cited by 22 publications

References 23 publications

Comparing the efficacy of low dose and conventional dose of oral isotretinoin in treatment of moderate and severe acne vulgaris

Comparing the efficacy of low dose and conventional dose of oral isotretinoin in treatment of moderate and severe acne vulgaris

Comparative Efficacy of Three Low - dose Isotretinoin Regimens in Treatment of Mild to Moderate Acne Vulgaris on the Face in Tertiary Care Institute

Self-Nanoemulsion Loaded with a Combination of Isotretinoin, an Anti-Acne Drug, and Quercetin: Preparation, Optimization, and In Vivo Assessment

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