Efficacy of DL-α lipoic acid against systemic inflammation-induced mice: antioxidant defense system

Jesudason, E. Philip; Masilamoni, J. Gunasingh; Jebaraj, Charles E.; Paul, Solomon F.D.; Jayakumar, R.

doi:10.1007/s11010-008-9748-y

Cited by 43 publications

(17 citation statements)

References 63 publications

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“…Furthermore, significantly higher SOD-1 and CAT protein levels were observed in mice subjected to ET alone than in SED-Tg mice, indicating that LA led to an effective reduction in oxidative insults. This finding is in accordance with several previous studies (21,40,45). Notably, we recently (13,16) demonstrated that combined application of ET and LA in APPsw mice was associated with greater improvements in antioxidant enzyme function in the brain than either treatment alone.…”

Section: Discussionsupporting

confidence: 93%

The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

Cho¹

2010

Int J Mol Med

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Abstract. Exercise training was suggested as a practical therapeutic strategy for human subjects suffering from Alzheimer's disease (AD) in our previous study. Therefore, the purpose of this study was to investigate the effects of combining exercise training with the administration of antioxidants on the pathological phenotype of AD. To accomplish this, non-transgenic mice (Non-Tg) and NSE/ APPsw Tg mice were treated with ·-lipoic acid and treadmill exercised for 16 weeks, after which their brains were evaluated to determine whether any changes in the pathological phenotype-related factors occurred. The results indicated that (i) the combination-applied (COMA) Tg group with exercise training (ET) and ·-lipoic acid administration (LA) showed ameliorated spatial learning and memory compared to the sedentary (SED)-Tg and single-treatment groups; (ii) there were no differences in the level of Aß-42 peptides across groups; (iii) the level of glucose transporter-1 and brain-derived neurotrophic factor proteins were highly increased in the COMA group, (iv) ET and LA did not induce a synergistic effect on the expression of heat shock protein-70 and apoptotic proteins including Bax and caspase-3; (v) the levels of SOD-1 and CAT suppressing oxidative stress were extensively higher in the COMA than in the singletreated groups and (vi) there were no significant differences across groups regarding these serum characteristics, although these levels were lower than the SED-Tg group. Taken together, these results suggest that the combination with ET and LA may contribute to protect the neuron injury induced by Aß peptides and may be considered an effective therapeutic strategy for human subjects suffering from AD.

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Section: Discussionsupporting

confidence: 93%

The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

Cho¹

2010

Int J Mol Med

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“…It can reduce oxidative stress by scavenging free radicals, chelating transition metals, increasing intracellular GSH and the redox regeneration of other antioxidants such as vitamins C and E [13-15,33,34]. In addition, LA also decreases oxidative stress by restoring enzymatic antioxidant system in blood in different status [34,35]. …”

Section: Discussionmentioning

confidence: 99%

Flaxseed oil and α-lipoic acid combination reduces atherosclerosis risk factors in rats fed a high-fat diet

Yang

Deng

et al. 2012

Lipids Health Dis

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BackgroundAtherosclerosis is a major manifestation of the pathophysiology underlying cardiovascular disease. Flaxseed oil (FO) and α-lipoic acid (LA) have been reported to exert potential benefit to cardiovascular system. This study tried to assess the effect of supplement of FO and LA combination on the atherosclerosis risk factors in rats fed a high-fat diet.MethodsLA was dissolved in flaxseed oil to a final concentration of 8 g/kg (FO+LA) when used. The rodent diet contained 20% fat. One-fifth of the fat was soybean oil and the others were lard (HFD group), or 75% lard and 25% FO+LA (L-FO+LA group), or 50% lard and 50% FO+LA (M-FO+LA group), or FO+LA (H-FO+LA group). Animals were fed for 10 weeks and then killed for blood collection.ResultsSupplement of FO and LA combination significantly enhanced plasma antioxidant defense capacities, as evaluated by the marked increase in the activities of SOD, CAT and GPx as well as the level of GSH, and the significant reduction in lipid peroxidation. Simultaneous intake of FO and LA also reduced plasma TG, TC and LDL-C contents and elevated the ratio of HDL-C/LDL-C. Besides, in parallel with the increase of FO and LA combination, plasma IL-6 and CRP levels were remarkably reduced.ConclusionSupplement of FO and LA combination may contribute to prevent atherogenesis by improving plasma oxidative stress, lipid profile and inflammation.

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“…On the other hand, ElBeshbishy et al, (2011) observed that CAT, SOD and GPx activities in kidney homogenate increased following treatment with alpha lipoic acid. Also, Jesudason et al, (2008) reported that, increased activities of SOD, CAT, GPx and glutathione level were observed in systemic inflammation after alpha lipoic acid treatment.…”

Section: Discussionmentioning

confidence: 97%

Anti-Oxidative Role Of Lipoic Acid Against Lead-Induced Hepatic Toxicity In Japanese Quails

Ismail¹,

Taha²,

Mandour³

et al. 2017

AJVS

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Key words:Quails; Lead; Lipoic acid; Antioxidant; Malondialdehyde, Copper Quails are exposed to deleterious doses of lead from different sources which decrease the bird performance, and growth with economic loses. This work aimed to explore the antioxidative effect of alpha lipoic acid to counteract the adverse effects of lead in Japanese quails. Forty Japanese quails with both sex were grouped into control, lead acetate (100 ppm in drinking water), alpha lipoic acid (1 g/kg diet), and the final group which received both lipoic acid and lead acetate of the same doses. Lead acetate significantly increased the liver enzymatic biomarkers (ALT, AST, and ALP), and bilirubin levels with decline in the serum total protein and albumin concentrations. Also, lead, copper concentrations in liver tissue were significantly increased with decreased hepatic iron level and serum calcium and phosphorus levels following lead acetate administration. Moreover, lead significantly increased hepatic malondialdehyde level with attenuation of antioxidant enzymes; GPX, GST, CAT, and SOD activities and nonenzymatic antioxidant; GSH concentration. Co-administration of alpha-lipoic acid together with lead acetate significantly improved the liver functions, increased the antioxidant activities, and corrected the serum and hepatic major and trace element concentrations without any effect on hepatic lead level. Our results suggested that alpha lipoic acid can counteract the deleterious effects of lead in quails through attenuation of oxidative stress and enhancement of antioxidative capacity in liver tissues.Correspondence to:

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Efficacy of DL-α lipoic acid against systemic inflammation-induced mice: antioxidant defense system

Cited by 43 publications

References 63 publications

The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

Flaxseed oil and α-lipoic acid combination reduces atherosclerosis risk factors in rats fed a high-fat diet

Anti-Oxidative Role Of Lipoic Acid Against Lead-Induced Hepatic Toxicity In Japanese Quails

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