Flaxseed oil and α-lipoic acid combination reduces atherosclerosis risk factors in rats fed a high-fat diet

Abstract

BackgroundAtherosclerosis is a major manifestation of the pathophysiology underlying cardiovascular disease. Flaxseed oil (FO) and α-lipoic acid (LA) have been reported to exert potential benefit to cardiovascular system. This study tried to assess the effect of supplement of FO and LA combination on the atherosclerosis risk factors in rats fed a high-fat diet.MethodsLA was dissolved in flaxseed oil to a final concentration of 8 g/kg (FO+LA) when used. The rodent diet contained 20% fat. One-fifth of the fat was soybean oil and the others were lard (HFD group), or 75% lard and 25% FO+LA (L-FO+LA group), or 50% lard and 50% FO+LA (M-FO+LA group), or FO+LA (H-FO+LA group). Animals were fed for 10 weeks and then killed for blood collection.ResultsSupplement of FO and LA combination significantly enhanced plasma antioxidant defense capacities, as evaluated by the marked increase in the activities of SOD, CAT and GPx as well as the level of GSH, and the significant reduction in lipid peroxidation. Simultaneous intake of FO and LA also reduced plasma TG, TC and LDL-C contents and elevated the ratio of HDL-C/LDL-C. Besides, in parallel with the increase of FO and LA combination, plasma IL-6 and CRP levels were remarkably reduced.ConclusionSupplement of FO and LA combination may contribute to prevent atherogenesis by improving plasma oxidative stress, lipid profile and inflammation.

Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard

“…The combination of FO and LA has been demonstrated to reduce atherosclerosis risk in our previous study [16]. The purpose of the present study was to determine whether the combination of FO and LA is able to decrease hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet.…”

Effect of fortification of milk with omega‐3 fatty acids, phytosterols and soluble fibre on the sensory, physicochemical and microbiological properties of milk

“…Owing to these problems encountered with fish oil, there is a need to look for alternative sources of omega‐3 fatty acids. Flaxseed oil usually contains more than 50% ALA and is one of the richest vegetarian sources of ALA . An effective avenue to increase the intake of omega‐3 fatty acids is through the incorporation of flaxseed oil in food products .…”

Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1

“…Due to its property as a safe, powerful antioxidant, ALA is widely used and well tolerated in the treatment of diabetic polyneuropathy (Coleman et al, 2001;Ziegler et al, 2006), atherosclerosis (Xu et al, 2012), Alzheimer's disease (Maczurek et al, 2008), acute Lung Injury (Lin et al, 2013). In the cardiovascular area, ALA attenuates cardiac dysfunction by reducing cardiomyocytes necrosis, apoptosis and inflammation after MI/R (Deng et al, 2013).…”