Efficacy of Diosmectite (Smecta)^®in the Treatment of Acute Watery Diarrhoea in Adults: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study

Abstract

Background. Although diosmectite has demonstrated efficacy in the treatment of acute watery diarrhoea in children, its efficacy in adults still needs to be assessed. The objective of this study was therefore to assess the efficacy of diosmectite on the time to recovery in adults with acute diarrhoea. Methods. A total of 346 adults with at least three watery stools per day over a period of less than 48 hours were prospectively randomized to diosmectite (6 g tid) or placebo during four days. The primary endpoint was time to diarrhoea recovery. Results. In the intention-to-treat population, median time to recovery was 53.8 hours (range [3.7–167.3]) with diosmectite (n = 166) versus 69.0 hours [2.2–165.2] with placebo, (n = 163; P = .029), which corresponds to a difference of 15.2 hours. Diosmectite was well tolerated. Conclusion. Diosmectite at 6 g tid was well tolerated and reduced the time to recovery of acute watery diarrhoea episode in a clinically relevant manner.

Application of montmorillonite in bentonite as a pharmaceutical excipient in drug delivery systems

“…Other toxic substances, such as nitroaromatic compounds, are strongly adsorbed by smectite clay, including montmorillonite (Haderlein and Schwarzenbach 1993;Boyd et al 2001;Li et al 2004;Roberts et al 2007). With this adsorption activity, a clay mineral group which has the montmorillonite structure, dioctahedral smectite (SMECTA Ò ) has been developed and is commercially available for treating of acute infectious diarrhea (Khediri et al 2011).…”

Experimental Study of the Antidiarrhoeal Activity of Montmorillonite-Containing Enterosorbent

“…Благодаря своим свойствам диоктаэдрический смектит обладает противодиарейным, цитомукопротекторным дей-ствием, имеет высокую сорбционную активность в отношении токсинов бактерий при пероральном применении [6,7]. Диосмектит с успехом исполь-зуется в качестве адъювантной терапии диарей, включая вирусную, в том числе у детей [8][9][10][11][12][13][14][15].…”

Diarrhées infectieuses aiguës de l’adulte : épidémiologie et prise en charge

“…Les diarrhées aiguës nosocomiales sont dans la majorité des cas dues à une infection intestinale. [16,17], le racécadotril (antisécrétoire) [18,19] ou certains produits inertes supposés renforcer la barrière muqueuse intestinale (diosmectite) [20] Le traitement comporte, après les prélèvements microbiologiques et ceux évaluant les pertes hydroélectrolytiques : un traitement antibiotique probabiliste en urgence ; la compensation par voie intraveineuse des pertes hydroélectrolytiques : hydriques sur la base de la perte de poids soudaine ; sodées sur la base d'une perte d'environ 50 mmol/L de sodium dans les selles ; potassiques si besoin (diarrhée profuse, vomissements associés) Une alcalinisation (par du bicarbonate 14%) peut être néces-saire, la diarrhée aiguë étant une des causes possibles des rares acidoses métaboliques avec hypokaliémie.…”