Application of montmorillonite in bentonite as a pharmaceutical excipient in drug delivery systems

Park, Ju-Hwan; Shin, Hyeon-Jong; Kim, Min Hwan; Kim, Jisu; Kang, Nae‐Won; Lee, Jae-Young; Kim, Ki-Taek; Lee, Jangik Ike; Kim, Dae‐Duk

doi:10.1007/s40005-016-0258-8

Cited by 146 publications

(75 citation statements)

References 117 publications

(180 reference statements)

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“…Solubility, dissolution rate, adsorption, and bioavailability of hydrophobic drugs are enhanced by montmorillonite. The effects of montmorillonite in improving the drug delivery system were reviewed [36].…”

Section: Drug Delivery Systemmentioning

confidence: 99%

Montmorillonite: An Introduction to Properties and Utilization

Uddin¹

2018

Current Topics in the Utilization of Clay in Industrial and Medical Applications

113

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Clay mineral is an important material available in nature. With an increasing understanding of clay structure, montmorillonite is realized viable for an enhanced performance in a variety of materials and products in the areas of catalysis, food additive, antibacterial function, polymer, sorbent, etc. Significant development in the use and application of montmorillonite is seen in recent time. This chapter provides an overview of montmorillonite, structure, and properties and particularly discusses its recent utilization in important materials. Montmorillonite is introduced in terms of its natural sources, chemical structure, physical and chemical properties, and functional utilization. The important physical and chemical properties are summarized as particle and layered structure, molecular structure and cation exchange effect, barrier property, and water sorption. This is followed by the important functional utilizations of montmorillonite based on the effects of its chemical structure. The important functional utilization of montmorillonite includes food additive for health and stamina, for antibacterial activity against tooth and gum decay, as sorbent for nonionic, anionic, and cationic dyes, and the use as catalyst in organic synthesis. The environment concerns, to date, do not indicate the adversity for particles used as additive. Studies will be useful which are clearly based on any montmorillonite structure to describe environmental effects.A common characteristic of clay mineral is a fine-grained natural structure in a sheet-like geometry. The sheet-structured hydrous silicates are generally called phyllosilicates [3]. The natural clay particle is smaller than 0.004 mm in diameter that may range from 0.002 to 0.001 mm for quartz, mica, feldspar, iron, and aluminum oxides [4]. Colloidal clay particles are finer and found in layered silicates (<0.001 mm in diameter).Clay minerals may be grouped in four types, shown in Table 1. The group members vary mainly in the layered structure. These include the kaolinite group, the smectite group (montmorillonite group), the illite group, and the chlorite group [5].The kaolinite group has three members including kaolinite, dickite, and nacrite; the formula for kaolinite group is Al 2 Si 2 O 5 (OH) 4 .The illite group is represented by mineral illite, the only common clay type. The general formula for illite is (K, H)Al 2 (Si, Al) 4 O 10 (OH) 2 ⋅ XH 2 O. It is an important rock-forming mineral and main component of shales. The structure of this group is similar to the montmorillonite group with silicate layers sandwiching an aluminum oxide/hydroxide layer in the same stacking sequence.The chlorite group is relatively large. This group is not necessarily considered as part of clays; therefore, it is placed as a separate group in phyllosilicate. The members in chlorite group are mesite, chamosite, cookeite, and daphnite with varying formulas and structures. There is no general formula.The variety of clay minerals is based on the arrangement of tetrahedral and octahedral s...

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Section: Drug Delivery Systemmentioning

confidence: 99%

Montmorillonite: An Introduction to Properties and Utilization

Uddin¹

2018

Current Topics in the Utilization of Clay in Industrial and Medical Applications

113

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“…Addition of Ca 2+ , Mg 2+ , Ni 2+ , Cu 2+ and Zn 2+ divalent metal ions into the BNT increases the surface affinity throughout the entire concentration range of isotherm which shows that divalent metal ions increase the ionic strength of BNT which increase the ionic interactions between adsorbate and adsorbents. Further, this higher percentage of adsorption affinity towards the metal incorporated BNT may be attributed to increase in an interlamilar space between two successive layers of clay [13]. An increase in the interlamilar space may facilitate the absorption of higher numbers of adsorbate molecules.…”

Section: Resultsmentioning

confidence: 96%

“…Out of 6 adsorbents, Mg 2+ exchanged BNT has been observed to have higher selectivity for biologically available L-ala as compare to D-ala at pH 4.0. So, such studies might be helpful for a better insight into the enantiomeric selection of molecules present in living system and role of pH 13 with a view to understand the abiotic evolution of life on the surface of minerals in prebiotic era of Earth.…”

Section: Discussionmentioning

confidence: 99%

Affinity of Metal Ions Incorporated Bentonite for Enantiomeric Interactions with Alanine

Pandey¹,

Bhatt²,

Jia³

et al. 2017

Preprint

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Explanation of the homochirality of amino acids in the biosphere is one of the most important mysteries in the origin of life. Following the abiotic evolution of life on Earth, possible role of prebiotically available mineral and metal ion have been widely studied. In this communication an effort has been made to investigate the surface interaction of L-alanine (L-ala) and D-alanine (D-ala) on Bentonite (BNT) and its divalent metal ion (M=Ca 2+ , Mg 2+ , Ni 2+ , Cu 2+ and Zn 2+ ) incorporated BNT for the optimal condition of pH, time, concentration and enantiomeric selectivity for D-and L-ala. Cu 2+ , Ni 2+ and Zn 2+ exchanged BNT have higher affinity for both the ala but Mg 2+ exchanged BNT have shown the selective adsorption of L-ala in comparison to the D-ala at pH 4.0±0.1. Further, absolute value of metal ion affinities with ala (ala-M 2+ ) and hydration effect on the relative stability and geometry of the individual species of ala-M 2+ ×(H2O)n, (n =2 and 4) has also been evaluated using DFT calculation. Possible implications for the stability and selectivity of biomolecules in prebiotic era of Earth has been discussed.

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“…Interaction between two successive layers of clay [13]. An increase in the interlamilar space may facilitate the absorption of higher numbers of adsorbate molecules.…”

Section: Resultsmentioning

confidence: 99%

“…These include high surface area, swelling and hydration properties, as well as strong cation exchange capacities (CEC). These characteristic properties, thus, enhance its capabilities as adsorbent, catalysis as well as in drug delivery [13].…”

Section: Introductionmentioning

confidence: 99%