Efficacy of demineralized bone matrix paste for maxillary sinus augmentation: A histologic and clinical study in humans

Sohn, Dong-Seok; Bae, Min-Su; Choi, Byung Jin; An, Kyung-Mi; Shin, Hong‐In

doi:10.1016/j.tripleo.2009.06.042

Cited by 13 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Table S1 summarizes the characteristics of included studies. In all studies, implants were placed following a staged protocol, except 10 studies in which implants were placed at the same time of a sinus augmentation procedure . In four studies, implants were placed either simultaneously with or after healing of sinus augmentation .…”

Section: Resultsmentioning

confidence: 99%

Histomorphometric results of different grafting materials and effect of healing time on bone maturation after sinus floor augmentation: a systematic review and meta‐analysis

Danesh-Sani

Engebretson

Janal

2016

J of Periodontal Research

113

141

View full text Add to dashboard Cite

The aim of this systematic review was to evaluate histomorphometric variables, the amount of new bone (NB), residual graft (RG) particles and soft tissue (ST), related to various grafting materials and assess the effect of graft healing time on different histomorphometric outcomes. Studies that were published before October 2015 were electronically and manually searched in three databases. We included human studies that reported the amount of NB, RG and ST in the biopsies taken from the grafted sinuses. Based on the applied grafting materials, extracted data were categorized into different groups. Furthermore, extracted data were classified into three groups based on healing time: (i) ≤ 4.5 mo; (ii) 4.5-9 mo; and (iii) ≥ 9-13.5 mo. The search provided 791 titles. Full text analysis was performed for 258 articles resulting in 136 studies that met the inclusion criteria. Autogenous bone (AB) resulted in the highest amount of NB and lowest amount of RG compared to other grafting materials. Based on this meta-analysis, a significant difference was noticed in the amount of NB formation in grafts with a healing time of > 4.5 mo when compared to the grafts with less healing time. However, when comparing biopsies taken at 4.5-9 mo of healing (average = 6.22 mo) to the ones taken at ≥ 9-13.5 mo (average = 10.36 mo), no significant difference was noticed in the amount of NB formation of various grafts except allografts that resulted in a significantly higher percentage of NB at 9.5 mo of healing. Based on histomorphometric analysis, AB results in the highest amount of NB formation in comparison to the other grafting materials. Bone substitute materials (allografts, alloplastic materials and xenografts) seem to be good alternatives to autogenous bone and can be considered as grafting materials to avoid disadvantages related to AB, including morbidity rate, limited availability and high volumetric change. Combining AB with alloplastic materials and xenografts brings no significant advantages regarding NB formation.

show abstract

Section: Resultsmentioning

confidence: 99%

Histomorphometric results of different grafting materials and effect of healing time on bone maturation after sinus floor augmentation: a systematic review and meta‐analysis

Danesh-Sani

Engebretson

Janal

2016

J of Periodontal Research

113

141

View full text Add to dashboard Cite

show abstract

“…Shanbhag and coworkers confirmed that AB presents one of the greatest volumetric contraction among the various bone substitutes, followed by allografts [48]. According to the different formulations of allograft (demineralized freeze-dried bone allograft, mineralized freeze-dried bone allograft or FFB), different behaviors in the maxillary sinus have been reported, probably with higher resorption rate and lower volumetric stability for demineralized allografts, even if associated with an increased osteoinductive potential related to the direct effect of growth factors [49,50]. FFB blocks were associated with satisfactory volumetric bone maintenance, even in more challenging regenerative procedures, such as posterior mandible augmentation [51].…”

Section: Discussionmentioning

confidence: 99%

Fresh Frozen Allogeneic Bone Block in Maxillary Sinus Floor Elevation: Histomorphometric Analysis of a Bone Specimen Retrieved 15 Years after Grafting Procedure

et al. 2019

View full text Add to dashboard Cite

Nowadays implant-prosthetic rehabilitations are one of the best solutions for rehabilitating our patients. These allow obtaining rehabilitations with optimal functional and aesthetic performances. Often patients, who undergo implant-prosthetic therapy, have the conditions of edentulias, single or multiple, that have been going on for some time. This, according to the literature, produces resorption of the alveolar bone, a process that is complicated in the posterior area of the upper arch by a pneumatization of the maxillary sinuses. The loss of vertical height, so that the implant fixtures can be inserted, requires a maneuver called maxillary sinus floor elevation. This procedure, now safely performed with piezoelectric instruments, allows increasing bone height through bone grafting. In this study, the tissue obtained from a patient, after 15 years from the intervention, was evaluated by histological and SEM analyses. The bone healing in the patient has led to a perfect integration between the patient’s bone and the fresh frozen allograft used, however still present and detectable after 15 years.

show abstract

“…20 Biomaterials that were used in this study did not cause any foreign body reaction as in previous clinical and experimental studies. 20,22,45,46 In many studies that determine the bone healing mechanisms of the graft materials in sinus floor augmentation procedures, newly formed connective tissue and the formation of vascular and bone tissue were evaluated histologically. 19,23,34,38 The histologic findings of the present study corroborated Kim et al, 19 who reported that PRF increases osteoblastic proliferation in early bone formation, indicating that osteoblastic proliferation was seen in the PRF combined with CHBG group more than the CHBG-only group at the second week, and PRF may have a positive effect on bone healing when combined with CHBG.…”

Section: Discussionmentioning

confidence: 99%

Experimental Evaluation of the Effectiveness of Demineralized Bone Matrix and Collagenated Heterologous Bone Grafts Used Alone or in Combination with Platelet-Rich Fibrin on Bone Healing in Sinus Floor Augmentation

Peker¹,

Karaca²,

Yıldırım³

2016

Int J Oral Maxillofac Implants

View full text Add to dashboard Cite

The aim of this study was an experimental evaluation of the effectiveness of demineralized bone matrix (DBM) and collagenated heterologous bone graft (CHBG) used alone or in combination with platelet-rich fibrin on bone healing in sinus floor augmentation procedures. Materials and Methods: In this study, 36 New Zealand rabbits were used. The bilateral sinus elevation was performed, and 72 defects were obtained. The rabbit maxillary sinuses were divided into four groups according to the augmentation biomaterials obtained: demineralized bone matrix (Grafton DBM Putty, Osteotech; DBM group), DBM combined with platelet-rich fibrin (PRF; DBM + PRF group), collagenated heterologous bone graft (CHBG; Apatos Mix, OsteoBiol, Tecnoss; CHBG group), CHBG combined with PRF (CHBG + PRF group). All groups were sacrificed at 2, 4, and 8 weeks after surgery for histologic, histomorphometric, and immunohistochemical analyses. Results: The inflammatory reaction was moderate to intense at the second week in all groups and declined from 2 to 8 weeks. New bone formation was started at the second week and increased from 2 to 8 weeks in all groups. There was no significant difference in bone formation between the experimental groups that used PRF mixed graft material and control groups that used only graft material. The percentage of new bone formation showed a significant difference in DBM groups and DBM + PRF groups compared with other groups. There were osteoclasts around all the bone graft materials used, but the percentage of residual graft particles was significantly higher in CHBG groups and CHBG + PRF groups at the eighth week. Conclusion: There is no beneficial effect of the application of PRF in combination with demineralized bone matrix or collagenated heterologous bone graft on bone formation in sinus floor augmentation. The results of this study showed that both collagenated heterologous bone graft and demineralized bone matrix have osteoconductive properties, but demineralized bone matrix showed more bone formation than collagenated heterologous bone graft.

show abstract

Efficacy of demineralized bone matrix paste for maxillary sinus augmentation: A histologic and clinical study in humans

Cited by 13 publications

References 17 publications

Histomorphometric results of different grafting materials and effect of healing time on bone maturation after sinus floor augmentation: a systematic review and meta‐analysis

Histomorphometric results of different grafting materials and effect of healing time on bone maturation after sinus floor augmentation: a systematic review and meta‐analysis

Fresh Frozen Allogeneic Bone Block in Maxillary Sinus Floor Elevation: Histomorphometric Analysis of a Bone Specimen Retrieved 15 Years after Grafting Procedure

Experimental Evaluation of the Effectiveness of Demineralized Bone Matrix and Collagenated Heterologous Bone Grafts Used Alone or in Combination with Platelet-Rich Fibrin on Bone Healing in Sinus Floor Augmentation

Contact Info

Product

Resources

About