Efficacy of Dapsone in Disseminated Granuloma Annulare: A Case Report and Review of the Literature

Martín-Sáez, E.; Fernández‐Guarino, M.; Carrillo-Gijón, R.; Muñoz-Zato, Ernesto; Jaén‐Olasolo, Pedro

doi:10.1016/s1578-2190(08)70196-3

Cited by 8 publications

(8 citation statements)

References 12 publications

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“…Ma on podwójne działanie -przeciwbakteryjne lub przeciwpasożytnicze oraz przeciwzapalne. W dermatologii wykorzystuje się przede wszystkim jego działanie przeciwzapalne, które polega na hamowaniu chemotaksji leukocytów wielojądrzastych i aktywacji dopełniacza drogą alternatywną [21,22]. Dapson jest lekiem pierwszego wyboru w terapii m.in.…”

Section: Conflict Of Interestunclassified

“…Its action is of a dual nature: antibacterial or antiparasitic and antiinflammatory. In dermatology, its anti-inflammatory effect is primarily used, which consists in inhibition of chemotaxis of polynuclear leukocytes and activation of the complement via an alternative route [21,22]. Dapsone is the drug of first choice in the treatment of, among others: herpetiform dermatitis, IgA pemphigus, linear IgA bullous dermatosis, subcorneal pustular dermatosis as well as hemorrhagic and long-lasting erythema.…”

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Therapeutic difficulties in a patient with a generalized form of annular granuloma

Stroynowska-Kosik¹,

Biało-Wójcicka²

2021

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Section: Conflict Of Interestunclassified

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confidence: 99%

Therapeutic difficulties in a patient with a generalized form of annular granuloma

Stroynowska-Kosik¹,

Biało-Wójcicka²

2021

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“…În forma generalizată de GI, prima linie de tratament este reprezentată de dermatocorticoizi și corticosteroizi intralezional, inhibitori topici de calcineurină sau fototerapie (27)(28). Terapiile sistemice presupun administrarea de hidroxiclorochină, isotretinoin sau dapsonă (29)(30)(31)(32).…”

Section: Managementul Giunclassified

“…În ceea ce privește dapsona, 100 mg/zi, studiile au arătat o rată mai mare a recăderilor la întrerupe-rea tratamentului. Tratamentul durează de la câteva săptămâni la 4 luni (32,46).…”

Section: Discuţiiunclassified

Provocările terapeutice ale unui „mare imitator“ – granulomul inelar generalizat

Şandru¹,

Dermatologie²,

Popa³

et al. 2019

Ro Med J.

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REzumatGranulomul inelar (GI) reprezintă o patologie cutanată benignă, de etiologie necunoscută. Se poate manifesta sub mai multe forme clinice: localizat, generalizat, subcutanat sau perforant. Asocierea dintre GI și diabetul zaharat, dislipidemie sau neoplasme nu este încă elucidată. Deși diagnosticul este în mare parte clinic, uneori poate fi necesar examenul histopatologic. Prezentăm cazul unei paciente în vârstă de 52 de ani, diabetică, hipertensivă, care a dezvoltat o erupție maculă-papuloasă, pruriginoasă, localizată pe membrele inferioare și abdomen, în evoluție de 6 luni. Am efectuat biopisie cutanată cu examen histopatologic, care a relevat infiltrate nodulare dermice alcătuite din histiocite palisadate în jurul unor colecții de mucine și însoțite de limfocite cu dispoziție perivasculară, modificări tipice pentru o leziune de granulom inelar. Am inițiat tratament sistemic cu isotretinoin, asociat cu dermatocorticoizi, cu evoluție favorabilă. Atât diagnosticul, cât și managementul unei pacient cu GI generalizat pot fi uneori dificile. Examenul histopatologic, în asociere cu un tablou clinic sugestiv, tranșează diagnosticul. Tratamentul se indică în cazurile severe, cu leziuni multiple, simptomatice, persistente.Cuvinte cheie: granulom inelar, isotretinoin, dermatocorticoizi, dapsonă aBStRaCt Granuloma annulare (GA) is a benign skin condition of unknown etiology. It can manifest itself in several clinical forms: localized, generalized, subcutaneous or perforating. The association between GI and diabetes, dyslipidemia or neoplasms is not yet elucidated. Although the diagnosis is clinical in most cases, a histopathological examination may be necessary. We presented the case of a 52 years old patient, diabetic, hypertensive, who reffered to our clinic, with a rash or macular-papular, pruritic, eruption, localization on the lower limbs and abdomen, in the evolution of 6 months. We performed skin biopsy with histopathological examination, which revealed: dermal nodular infiltrates consisting of palisadiate histiocytes, in several mucin collections and signified by lymphocytes with perivascular arrangement, typical modifications for an annular granuloma lesion. We have initiated systemic treatment with isotretinoin, associated with dermatocorticoids, with favorable evolution. Diagnosis, aș well aș the management of a patient with generalized GI, can sometimes be difficult. The histopathological examination, in combination with a suggestive clinical picture, makes the diagnosis. Treatment is indicated in severe cases, with multiple, symptomatic, persistent lesions.

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“…Elsősorban szulfon, antituberculotikum, és tetraciklin hatásosságát emelik ki (3,26,27). Per os alkalmazott dapsone napi 100 mg dózisban hatásos lehet (23). Orális isotretinoinnal is történtek próbálkozások, és az esetek többségében a betegség regreszsziójához is vezetett.…”

Section: Esetismertetésunclassified

Disseminated granuloma annulare in one case

Licskai¹,

Somogyi²,

Gyömörei³

et al. 2019

BVSZ

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ÖSSZEFOGLALÁSA granuloma anulare egy ismeretlen etiológiájú ritka bőrgyógyászati kórkép. A szerzők egy 51 éves nőbeteg esetét ismertetik, akinek mindkét lábszárán, kézfejek feszítő felszínén kiterjedten centrifugálisan terjedő anularis erythemas plakkokkal jelentkezett. Szövettani vizsgálat granuloma anulare diagnózisát állította fel. A beteg kivizsgálása során a gócés tumorkutatása negatív eredményt adott. Krónikus vírusinfekciót nem verifikáltak. Tünetei ezidő alatt az alkalmazott szisztémás és lokális kezelések ellenére fennálltak. Irodalmi adatok alapján, a további progresszió miatt a betegnél biológiai therápiát (TNF-alfa gátlót) indítottak. A szerzők jelen közleményükben összefoglalták a beteg esete kapcsán a granuloma anulare kezelési lehetőségeit.

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Efficacy of Dapsone in Disseminated Granuloma Annulare: A Case Report and Review of the Literature

Cited by 8 publications

References 12 publications

Therapeutic difficulties in a patient with a generalized form of annular granuloma

Therapeutic difficulties in a patient with a generalized form of annular granuloma

Provocările terapeutice ale unui „mare imitator“ – granulomul inelar generalizat

Disseminated granuloma annulare in one case

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