Efficacy of Dapsone 5% gel in treatment of Acne vulgaris

Abstract

<p class="abstract"><strong>Background:</strong> Acne vulgaris is chronic inflammatory disorder of pilosebaceous unit mainly characterized by comedones, papules and nodulocystic lesions affecting face and upper trunk. Topical dapsone 5% gel is approved to treat acne vulgaris because of its anti-inflammatory and anti-bacterial activities.</p><p class="abstract"><strong>Methods:</strong> A single center, open label interventional study was conducted during 1 year period in dermatology OPD of Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra. Patients were enrolled in the study considering inclusion criteria. Patients were asked to apply dapsone 5% gel twice daily on face for 12 week. Efficacy was evaluated by mean percent reduction in total, inflammatory and non-inflammatory lesions and success rate on change in investigator global acne severity assessment scale while tolerability was assessed by evaluating skin dryness, erythema, stinging or burning sensation and scaling at baseline, 1, 2, 4, 8 and 12 week.<strong></strong></p><p class="abstract"><strong>Results:</strong> At end of 12 week, success rate reached to 31.54%. Dapsone 5% gel was effective in reduction of total, non-inflammatory and inflammatory lesions by 57.75%, 52% and 63.1% respectively. Side effects with dapsone gel were tolerable, mild and transient.</p><p><strong>Conclusions:</strong> Dapsone 5% gel was efficacious and well tolerated in non-inflammatory as well as inflammatory acne lesions. </p>

Emerging Role of Dapsone in the Management of Acne Vulgaris: Review Article

“…Helpful and well-tolerated Dapsone 5 percent gel was found to be effective in both non-inflammatory and inflammatory acne lesions (19) .…”

“…Jawade & Singh (19) topical dapsone 5 percent gel for the treatment of acne vulgaris was the subject of research, After 12 weeks, the success rate was 31.54 percent. Overall lesions were reduced by 57%, noninflammatory lesions by 52%, and inflammatory lesions by 63% with the use of Dapsone 5 percent gel, respectively.…”

Formulation, Development and Evaluation of Antiacne Dapsone Gel

“…The prevalence of acne vulgaris reported from various countries ranges to 87% of adolescents and up to 54% of adults.1 Though acne is self limiting disease, the presence of active acne lesions impacts the physical appearance and creates negative effects on psycho-social function for individual. [7] Orally administered dapsone is known to cause hematologic reactions, including methemoglobinemia; hemolysis, especially in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency; and agranulocytosis. [8] In present research work, topical delivery of Dapsone as a drug of choice towards acne treatment and Gel was formulated using polymer carbopol 971P along with different excipients.…”