Background: Skin illness Acne Vulgaris (AV) is characterized by excessive sebum production, follicular hyperkeratinization, and long-term pilosebaceous unit irritation. Acne can persist into adulthood in 12-14% of instances, resulting in deformity and chronic scarring that can have psychological and social consequences. Acne scars, feelings of negative effects on psychology, isolation from society, and depression can all be long-term repercussions of the condition. In a small percentage of patients with nodulocystic acne, the anti-inflammatory drug Dapsone, developed in the 1950s, was found to be beneficial. However, the risk of systemic side effects has limited the use of dapsone in clinical practice. Topical dapsone gel was licensed for acne treatment following two double-blind, randomized trials that established its therapeutic efficacy. Objective: Summarize the role that Dapsone plays in the treatment of Acne Vulgaris. Methods: The databases were searched for articles published in English in 3 databases [PubMed -Google scholarscience direct] and Boolean operators (AND, OR, NOT) had been used such as [Management of Acne Vulgaris AND Dapsone OR Acne Vulgaris] and in peer-reviewed articles between March 2001 and April 2020. Conclusion: Acne vulgaris can be effectively treated with topical Dapsone, according to clinical trials.
Background: Long-term treatment with low to moderate dosages of the antimetabolite and antifolate medication methotrexate (MTX) has been shown to be effective, safe, and well-tolerated for a wide range of autoimmune diseases. As a result, methotrexate may be used to treat vitiligo and other autoimmune disorders. The hepatotoxic and hematologic side effects of the drug's topical formulations, which were developed for the treatment of localized lesions, were deemed to be clinically insignificant. Objective: This review article aimed to assess the possible role of topical methotrexate in the management of vitiligo. Methods: Methotrexate, and the vitiligo were all looked for in PubMed, Google scholar, and Science direct. References from relevant literature were also evaluated by the authors, but only the most recent or complete studies from January 2005 to May 2021 were included. Due to the lack of sources for translation, documents in languages other than English were ruled out. Papers that did not fall under the purview of major scientific investigations, such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations, were omitted. Conclusion: Topical methotrexate use could be an effective and safe treatment modality of vitiligo.
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