Efficacy of daily and monthly high-dose calciferol in vitamin D–deficient nulliparous and lactating women

Saadi, Hanane; Dawodu, Adekunle; Afandi, Bachar; Zayed, Reem; Benedict, Sheela; Nagelkerke, Nicolaas

doi:10.1093/ajcn/85.6.1565

Cited by 94 publications

(79 citation statements)

References 29 publications

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“…Recent supplementation studies have involved non-pregnant participants. Serum 25OHD was significantly increased by administration of 60 000 U of vitamin D2 per month for 3 months in lactating women (Saadi et al, 2007). However, levels 450 nmol/l were achieved only in 30% participants.…”

Section: Discussionmentioning

confidence: 85%

Vitamin D replacement in pregnant women in rural north India: a pilot study

et al. 2009

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Hypovitaminosis D is common in both urban and rural Indians. The dose of vitamin D needed for the treatment of its deficiency during pregnancy is not clear. We conducted a study in rural Indians to evaluate the effect of cholecalciferol supplementation during routine antenatal visits on maternal 25 hydroxyvitamin D (25OHD) at delivery. Pregnant women received either no cholecalciferol (Group A) or 60 000 U (Group B) in the fifth month of gestation or 120 000 U each in the fifth and seventh gestational months (Group C). Serum 25OHD was measured at baseline (n ¼ 139) and at delivery (n ¼ 84). Median (interquartile range) 25OHD

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Section: Discussionmentioning

confidence: 85%

Vitamin D replacement in pregnant women in rural north India: a pilot study

et al. 2009

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“…As described in the literature, keeping vitamin D levels in the normal range appears to require not waiting to intervene until levels fall below 75 nmol/L For example, in a study performed in the United Arab Emirates, Saadi et al reported a high prevalence of vitamin D deficiency (mean level of 19 nmol/L at inclusion) and also confirmed the importance of vitamin D supplementation in patients that are rarely exposed to the sun [9].…”

Section: Correction Of the Deficiency And Preservation Of The Levelmentioning

confidence: 84%

“…A bibliographic review by Vieth showed that hypercalcemia is always accompanied by serum vitamin D levels higher than 220 nmol/L [7][8][9][10][11].…”

Section: Innocuity Of Vitamin Dmentioning

confidence: 99%

Management of vitamin D deficiency in young women with 1-year follow up

Perdrix¹,

Large²,

Fauche³

et al. 2012

OJPM

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“…Majority of women who are deficient in vitamin D, are advised to take treatment for 4-6 weeks, either with cholecalciferol 20 000 IU a week or ergocalciferol 10 000 IU twice a week, followed by standard supplementation. 24,25 The women who require short-term repletion, 20 000 IU weekly appears to be an effective and safe treatment of vitamin D deficiency. A daily dose is likely to be appropriate to maintain subsequent repletion (1000 IU daily).…”

Section: Discussionmentioning

confidence: 99%

A Case of Neonatal Hypocalcaemia Due to Maternal Vitamin D Deficiency

Hasina

Hassan²

2017

Bangladesh J Child Health

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IntroductionNeonatal hypocalcaemia (NH) is a commonly reported metabolic abnormality in neonate. Ionized calcium is vital for various metabolic pathways like blood coagulation, neuronal depolarization, integrity of cell membrane, enzyme catalysis etc. Major part of the body calcium exists in bones and muscles (99%) and the rest of the calcium is present in extracellular fluid (1%). In extracellular fluid about 40% calcium is bound to albumin, another 10% is bound to citrate, phosphorus, lactate and sulfate and the rest (50%) exists as ionized free form, help in metabolic functions. 1,2 Hypocalcaemia has significant negative impact on newborn health. It is defined as total serum calcium of <8 mg/dL (2 mmol/L) or ionized calcium of <1.2 mmol/L in term neonates, and<7 mg/dL (1.75 mmol/L) of total calcium or <4 mg/dL (1 mmol/L) of ionized calcium in preterm infants. 3 Causes of neonatal hypocalcaemia is diverse like prematurity, perinatal asphyxia, cow milk feeding. Maternal Vitamin D deficiency has also been reported as a cause of neonatal hypocalcaemia. We are reporting a case of neonatal hypocalcaemia attributed to maternal Vitamin D deficiency in Asian context. Case Report 9 days old out born boy was admitted in NICU of Apollo Hospitals Dhaka on 3 rd September 2014 with h/o seizures. In immediate neonatal period, in a different hospital where he was born, the baby developed mild transient tachypnoea of newborn which required no active management. He was discharged from that hospital on 3 rd postnatal day. At 7 th day of age he developed convulsion and was re-admitted to that hospital. His convulsion was generalized in nature, 4-5 episodes with duration of approximately 10 seconds each. He was initially treated in that hospital with anticonvulsant, antibiotic and calcium gluconate but as condition was deteriorating, he was transferred to Apollo hospital at 9 th day of age. The pregnancy was unremarkable and the baby was born at term by an uncomplicated caesarian section. His birth weight was 2580 gram (10th to 25th percentile). Mother had bronchial asthma, otherwise family history was noncontributory. There was no history of fever, trauma or sepsis related risk factors. The baby was breastfed and supplemented with formula feed. The baby's weight was 2580gram. He was afebrile with normal vital signs. He had no dysmorphic features and physical examination was otherwise unremarkable. Twenty four hours after admission, the baby developed 2 episodes of focal convulsion for 10 seconds each. A Case of NeonatalInitial blood work showed normal septic screening, renal function and electrolytes with hypocalcemia (total calcium 6 mg/dl (8.5 to 10.5 mg/dl ) and hyperphosphataemia. Blood glucose level was 4.3mmol/L. The diagnosis was revealed after further maternal history and blood tests. On further query, the mother did not take any antenatal vitamin supplements. The baby had not been started on vitamin D supplements.Vitamin D deficiency in the infant was diagnosed on the basis of a low 25-hydroxy vitamin D level at 19 nmol/...

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Efficacy of daily and monthly high-dose calciferol in vitamin D–deficient nulliparous and lactating women

Cited by 94 publications

References 29 publications

Vitamin D replacement in pregnant women in rural north India: a pilot study

Vitamin D replacement in pregnant women in rural north India: a pilot study

Management of vitamin D deficiency in young women with 1-year follow up

A Case of Neonatal Hypocalcaemia Due to Maternal Vitamin D Deficiency

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