Efficacy of cyclosporin in the treatment of atopic dermatitis in dogs ‐ combined results from two veterinary dermatology referral centres

Burton, Gregory G.; Burrows, Arthur; Walker, Russell; Robson, David; Bassett, R J; Bryden, Sharon L.; Hill, Andrew

doi:10.1111/j.1751-0813.2004.tb12153.x

Cited by 15 publications

(23 citation statements)

References 16 publications

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“…According to Burton et al (2004), statistically significant differences are observed after 27-42 days of the treatment with the use of cyclosporine at a dose of 0.5 mg/kg b.w./day administered orally.…”

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confidence: 99%

The evaluation of Canine Atopic Dermatitis Extent and Severity Index (CADESI) test in dogs with Atopic Dermatitis (AD) treated with cyclosporine or prednisone

Taszkun

2010

Polish Journal of Veterinary Sciences

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The purpose of this study was to assess the clinical state of dogs with atopic dermatitis (AD) by use of CADESI test in own modification during the first visit in the Dermatology Consult Room as well as during the treatment. The study was performed in two groups (I-E and II-C) of 20 dogs in each group. In dogs which were qualified to the I-E group, as antiallergic, anti-inflammatory and antipruritic treatment, prednisone (oral preparation Encorton -Polfa Pabianice) at dose 0.5 mg/kg b.w./day was administered, while in dogs qualified to the II-C group -cyclosporine (oral preparation Sandimmun Neoral -Novartis Pharma) at a dose of 5 mg/kg b.w./day; the treatment was continued for 6 weeks in both groups. During the study, skin lesions were assessed in 15 specified body areas using 4 parameters and 5-point scale. In group I-E and II-C the amount of received points in CADESI test was decreased by 82.26% and by 83% respectively, after the treatment. Statistical analyses of the results obtained revealed no statistically significant (P=0.05) differences between means of I-E and II-C groups in consecutive examinations, which indicates comparable clinical efficacy of both drugs. Statistically significant differences (P=0.05) of the parameters assessed were found after secondary dermatoses treatment, and after every two weeks of antipruritic and anti-inflammatory treatment.

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confidence: 99%

The evaluation of Canine Atopic Dermatitis Extent and Severity Index (CADESI) test in dogs with Atopic Dermatitis (AD) treated with cyclosporine or prednisone

Taszkun

2010

Polish Journal of Veterinary Sciences

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“…As reações adversas (gastroentéricas) observadas no estudo, associadas à administração de ciclosporina foram baixas, e prevalecem em relação a outros sintomas, porém, geralmente, são comuns, discretas, transitórias e não exigem tratamento ou interrupção precoce da terapia, corroborando com outros estudos (Fontaine & Olivry 2001, Olivry et al 2002a, 2002b, Olivry & Mueller 2003, Burton et al 2004, Radowicz & Power 2005, Steffan et al 2006, Lucas et al 2007, Yazbek & Larsson 2012.…”

Section: Discussionunclassified

“…No presente ensaio, mesmo com a retirada dos corticóides, a ciclosporina se manteve eficaz no controle sintomato-lesional a partir do 14º até o 60º dia de tratamento, coincidindo com os resultados obtidos por Fontaine & Olivry (2001), Olivry et al (2002aOlivry et al ( , 2002b, Burton et al (2004), Steffan et al (2005), Steffan et al (2006), Lucas et al (2007), Yazbek & Larsson (2012). .…”

Section: Discussionunclassified

“…A eficácia e segurança da ciclosporina no controle da DAC foi documentada por diversos autores (Fontaine & Olivry 2001, Olivry et al 2002a, 2002b, Olivry & Mueller 2003, Burton et al 2004, Radowicz & Power 2005, Steffan et al 2006, Lucas et al 2007, Yazbek & Larsson 2012), e com taxas de 71 a 75% de satisfação do proprietário (Yazbek & Larsson 2012).…”

Section: Introductionunclassified

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Eficácia da ciclosporina no controle da dermatite atópica em cães

Neto

Farias²,

Pimpão

et al. 2017

Pesq. Vet. Bras.

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RESUMO.-A dermatite atópica é uma dermatopatia inflamatória, pruriginosa, crônica, de origem genética, resultante da perda da função de barreira física da pele e da hiperreatividade à alérgenos ambientais, trofoalérgenos, alérgenos microbianos e a irritantes primários. Este estudo avaliou a eficácia da ciclosporina no controle do prurido e das lesões associadas à dermatite atópica em cães. Selecionaram-se 24 cães com diagnóstico de dermatite atópica ba- Atopic dermatitis is an itchy, chronic inflammatory skin disease of genetic origin, resulting from loss of the physical barrier function of the skin and hyper-reactivity to environmental allergens, trofoallergens, microbial allergens and to primary irritants. The efficacy of cyclosporine in the control of pruritus and lesions associated with atopic dermatitis in dogs was evaluated. Twenty-four dogs with atopic dermatitis were selected, based on Favrot et al.'s criteria (2010). They were divided into two groups of 12 dogs, where Group 1 received cyclosporine (5mg/kg/vo/24h), and Group 2 was treated with prednisone (0.5mg/kg/ vo/24h) in decreasing doses, both for 60 days. The animals were continuously evaluated, and theirits lesional symptomatology scores were based on a Cadesi-03 scale, set on days 0, 30 and 60. Pruritus scores of each dog, based on Rybnicek´s criteria, were weekly evaluated, from day 0 to day 63. All collected data were analyzed by the nonparametric Kruskal--Wallis´ test, followed by Dunn's test, and for the analysis between the groups, considered the minimum significance level of 5%, t-test was used. Cyclosporin had similar efficacy in lesional control in the group which received prednisone on day (+30) (p<0.05) and on the day (+60) (p<0.001) of treatment, compared with day zero. A significant difference of the itching score was observed on days +28, +35, +42, +49, +56 and +63 (p<0.001), and on day +21 (p<0.01) when compared to initial treatment. However, its efficacy was lower than Group 2, from 42 days of evaluation on, keeping such difference on days +49, +56 and +63 (p>0.05). Although cyclosporin have been less effective in controlling itching, it remained at acceptable levels, and its continued use was not associated with significant side effects.

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“…Lesion severity, 1 pruritus severity, 2 intradermal test reactivity, 12 and global assessment scales, 13 are examples of ordered categorical scales used in veterinary dermatology. Many scales are used in an ad hoc manner for lack of a validated alternative.…”

Section: Introductionmentioning

confidence: 99%

Frequency of appropriate and inappropriate presentation and analysis methods of ordered categorical data in the veterinary dermatology literature from January 2003 to June 2006

Plant

Giovanini

Villarroel

2007

Veterinary Dermatology

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What is known about the topic of this paper • Ordered categorical level data do not contain as much information as interval level data.• Ordered categorical scales require statistical methodology different than that required for continuous data in order to be consistent with the structure of the data.• Ordinal data are frequently presented and analysed with inappropriate methods in the human medical literature.

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Efficacy of cyclosporin in the treatment of atopic dermatitis in dogs ‐ combined results from two veterinary dermatology referral centres

Abstract: Cyclosporin was well tolerated and efficacious in the symptomatic treatment of atopic dermatitis in dogs attending two veterinary dermatology referral centres in Australia, under Australian field conditions, when administered at 5 mg/kg/day for 6 weeks.

Cited by 15 publications

References 16 publications

The evaluation of Canine Atopic Dermatitis Extent and Severity Index (CADESI) test in dogs with Atopic Dermatitis (AD) treated with cyclosporine or prednisone

The evaluation of Canine Atopic Dermatitis Extent and Severity Index (CADESI) test in dogs with Atopic Dermatitis (AD) treated with cyclosporine or prednisone

Eficácia da ciclosporina no controle da dermatite atópica em cães

Frequency of appropriate and inappropriate presentation and analysis methods of ordered categorical data in the veterinary dermatology literature from January 2003 to June 2006

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