Efficacy of Cryotherapy versus Intralesional Meglumine Antimoniate (Glucantime) for Treatment of Cutaneous Leishmaniasis in Children

Abstract

We compared intralesional glucantine and cryotherapy for treatment of children with cutaneous leishmaniasis in Iran. We observed that cryotherapy is an effective treatment for cutaneous leishmaniasis in children. No serious post-treatment side effects were observed in either group. At six months of follow-up, no recurrence of disease was observed in cured patients in either group. Because of its simplicity, lower cost, low rate of serious complications, and greater tolerability, cryotherapy should be recommended as an appropriate alternative treatment for leishmaniasis in children.

Treatment Patterns and Effectivness of Anti-Leishmaniasis Agents for Patients with Cutaneous Leishmaniasis at Boru Meda Hospital, South Wollo, North East Ethiopia, 2017/18

“…This might be due to both researches were conducted on old world cutaneouse leishmaniasis cases with administration of parental SSG and local therapy (IL SSG). But the result was relatively low when compared to a study conducted in United States [13] and report from Medicines and Health care products Regulatory Agency (90%) [14]. This might be due to different etiological agents that cause leishmaniasis in New world and Old world.…”

“…Local treatments based on intralesional pentavalent antimonials, topical paromomycin, thermotherapy, or cryotherapy are used for certain cases of cutaneous leishmaniasis. But as few studies in the New world cutaneouse leishmaniasis revealed that the combined therapies between systemic sodium stibogluconate (SSG) with Allopurinol, ketoconazol, cryotherapy and intra-lesional SSG showed promising effects for patients with cutaneouse leishmaniasis [12][13][14]. Thus, this study was aims to assess the patterns of treatment and its effectiveness among patients with six categories of cutaneouse leishmaniasis for treatment type under study.…”

Topical Treatment Modalities for Old World Cutaneous Leishmaniasis: A Review

“…Simplicity, lower cost, low rate of serious complications and greater tolerability can make cryotherapy an appropriate alternative treatment for cutaneous leishmaniasis in children (Layegh et al, 2009).…”

Successful Treatment with Intralesional Meglumine Antimoniate in Recurrent Cutaneous Leishmaniasis: Case Report

“…There are cases and series of cases in the literature of cutaneous leishmaniasis treated with intralesional antimonials showing divergent results, some with satisfactory results, with cure rates as high as 70-80% [7,8] and others with poor cure rates [9,10].…”