Efficacy of Crosseal Fibrin Sealant (Human) in Rhytidectomy

Abstract

Crosseal is efficacious in reducing ecchymoses after rhytidectomy.

Fibrin sealants in soft tissue surgery of the head and neck: A systematic review and meta‐analysis of randomised controlled trials

“…included patients having central neck dissection, whereas Vidal‐Perez et al . included patients having central and lateral neck dissections), one at lateral neck dissection, one at parotidectomy and five at rhytidectomy . Only six of the included studies reported a sample size calculation and only three of these reached the planned sample size.…”

Comparison of Postoperative Eyelid Position Using Fibrin Sealant versus Suture for Wound Closure in Müllerʼs Muscle–Conjunctiva Resection Ptosis Repair

“…2 A previously described alternative sutureless technique was complicated by wound dehiscence, tarsal buckling, and undercorrection, and has since been largely abandoned. [5][6][7][8][9][10][11][12] The safety of Müller's muscle-conjunctiva resection ptosis repair using fibrin sealant for wound closure has previously been reported in the literature. The combination of these components produces a fibrin clot, which is adhesive to human tissues.…”

Efficacy and safety of fibrin sealant for tissue adherence in facial rhytidectomy

“…Case reports,11,12,31 large series,13,14,32–35 and randomized prospective trials27,36,37 support the value of using fibrin sealant in rhytidectomy. Several investigators question some of the reported advantages of this material 38–40.…”

“…In a small, FDA sponsored, single institution, randomized, prospective trial of patients (n = 9) with pressure dressings applied to all patients, reviewers blinded to treatment, and randomly varying the side of the face treated with fibrin sealant (Crosseal; Omrix, Brussels, Belgium),37 a significant reduction in the treated patient sides was found for ecchymosis score, 4.5 versus 6.2 ( P < 0.01). No significant reductions in hematoma or seroma formation were found.…”