Efficacy of Cranberry Juice on <i>Helicobacter pylori</i> Infection: a Double‐Blind, Randomized Placebo‐Controlled Trial

Ma, Junling; Pan, Kai-Feng; Go, Vay Liang W.; Chen, Junshi; You, Wei‐Cheng

doi:10.1111/j.1523-5378.2005.00301.x

Cited by 124 publications

(95 citation statements)

References 38 publications

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“…In the former case, there was a beneficial cran- berry effect in preventing urinary tract infections [15,16]. In the mixed populations, cranberry consumption significantly increased the eradication of H. pylori compared to placebo [22]. Nevertheless, the eradication rate of cranberry alone was far below that of triple therapy.…”

Section: Discussionmentioning

confidence: 95%

“…in a mice model of H. pylori infection caused a significant clearance of the H. pylori mass, but it had no effect on eradicating the pathogen from the gastric lumen [21]. In a randomized controlled study, cranberry juice alone accounted for a 15% of the H. pylori eradication, compared to 5% for placebo [22]. Although this effect in naturally infected humans was significant, the rate of eradication was still considerably lower than that of conventional triple therapy.…”

Section: Introductionmentioning

confidence: 97%

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Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics and a proton pump inhibitor

Shmuely

Yahav

Samra

et al. 2007

Molecular Nutrition Food Res

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Cranberry constituents are known to exert anti-adhesion activity on H. pylori in vitro. To determine their possible additive effect to triple therapy with omeprazole, amoxicillin and clarithromycin (OAC), a double-blind randomized clinical study was carried out. One-hundred-seventy-seven patients with H. pylori infection treated with OAC for 1 week were randomly allocated to receive 250 mL of either cranberry juice (cranberry-OAC, n = 89) or placebo beverage (placebo-OAC, n = 88) twice daily and only cranberry juice or placebo beverage for the next 2 weeks. Treatment outcome was determined with the(13)C urea breath test ((13)C-UBT). An additional control group consisted of patients referred to the same center during the same period who were treated with OAC alone for 1 week (non-placebo-OAC, n = 712). Overall, the rate of H. pylori eradication ((13)C-UBT < 3.5) was 82.5%, with no statistically significant difference among the three arms. Analysis by gender revealed that for female subjects, the eradication rate was higher in the cranberry-OAC arm (n = 42, 95.2%) than in the placebo-OAC arm (n = 53, 86.8%) and significantly higher than in the non-placebo-OAC group (n = 425, 80%; p = 0.03). For males, the rate was nonsignificantly lower in the cranberry-OAC arm (n = 35, 73.9%) than in the placebo-OAC arm (n = 45, 80.0%) and non-placebo-OAC group (n = 287, 85.0%). These results suggest that the addition of cranberry to triple therapy improves the rate of H. pylori eradication in females.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 97%

Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics and a proton pump inhibitor

Shmuely

Yahav

Samra

et al. 2007

Molecular Nutrition Food Res

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“…Antibacterial adhesion studies demonstrated that in addition to inhibiting E. coli adhesion, cranberry components also inhibit adhesion of H. pylori to human gastric mucus [78]. A randomized, double-blind placebo-controlled trial provided some clinical support for this finding, with significantly lower levels of H. pylori infection observed in adults consuming cranberry juice [79].…”

Section: Helicobacter Pylori Inhibitionmentioning

confidence: 95%

Anticancer activities of cranberry phytochemicals: An update

Neto¹,

Amoroso²,

Liberty³

2008

Mol. Nutr. Food Res.

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Studies employing mainly in vitro tumor models show that extracts and compounds isolated from cranberry fruit (Vaccinium macrocarpon) inhibit the growth and proliferation of several types of tumor including breast, colon, prostate, and lung. Proanthocyanidin oligomers, flavonol and anthocyanin glycosides and triterpenoids are all likely contributors to the observed anticancer properties and may act in a complementary fashion to limit carcinogenesis. Possible chemopreventive mechanisms of action by cranberry phytochemicals include induction of apoptosis in tumor cells, reduced ornithine decarboxylase activity, decreased expression of matrix metalloproteinases associated with prostate tumor metastasis, and anti-inflammatory activities including inhibition of cyclooxygenases. A review of recent studies suggests a potential role for cranberry as a dietary chemopreventive and provides direction for future research.

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“…However, in vivo studies with garlic (19), jalapeño peppers (20), cinnamon extract (21), broccoli (22), and cranberry juice (23) failed to eradicate H. pylori infection in spite of the wellreported antibacterial data obtained from in vitro experiments. With this concern in mind, researchers have recommended the consumption of these natural foods as chemopreventive agents (6) or in combination with antibiotics to eradicate the bacterial infection (24).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Activity of Olive Oil Polyphenols against Helicobacter pylori

Romero

Medina

Vargas

et al. 2007

J. Agric. Food Chem.

168

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Helicobacter pylori is linked to a majority of peptic ulcers and to some types of gastric cancer, and resistance of the microorganism to antibiotic treatment is now found worldwide. Virgin olive oil is an unrefined vegetable oil that contains a significant amount of phenolic compounds. Under simulated conditions, we have demonstrated that these substances can diffuse from the oil into the gastric juice and be stable for hours in this acidic environment. In vitro, they exerted a strong bactericidal activity against eight strains of H. pylori, three of them resistant to some antibiotics. Among the phenolic compounds, the dialdehydic form of decarboxymethyl ligstroside aglycon showed the strongest bactericidal effect at a concentration as low as 1.3 μg/mL. Although the experimental conditions are different from other reported works, this bactericidal concentration is much lower than those found for phenolic compounds from tea, wine, and plant extracts. These results open the possibility of considering virgin olive oil a chemopreventive agent for peptic ulcer or gastric cancer, but this bioactivity should be confirmed in vivo in the future. Keywords: Olive oil; phenolic compounds; simulated digestion, Helicobacter pylori; antimicrobial

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Efficacy of Cranberry Juice on Helicobacter pylori Infection: a Double‐Blind, Randomized Placebo‐Controlled Trial

Abstract: Regular consumption of cranberry juice can suppress H. pylori infection in endemically afflicted populations.

Cited by 124 publications

References 38 publications

Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics and a proton pump inhibitor

Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics and a proton pump inhibitor

Anticancer activities of cranberry phytochemicals: An update

In Vitro Activity of Olive Oil Polyphenols against Helicobacter pylori

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