Efficacy of cord blood platelet gel application for enhancing diabetic foot ulcer healing after lower limb revascularization

Volpe, Pietro; Marcuccio, Daniela; Stilo, Giuseppe; Alberti, Antonino; Foti, Giovanni; Volpe, Alberto; Princi, Domenica; Surace, Rosangela; Pucci, Giulia; Massara, Mafalda

doi:10.1053/j.semvascsurg.2017.12.001

Cited by 31 publications

(39 citation statements)

References 15 publications

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“…Platelets for PG come from patients' own blood, 5,8,54,55,57,60,65,68,71,76 donors' blood, 56,58,[61][62][63]67,69,72 and cord blood. 59,[73][74][75] Advantages of APG are no need for blood type matching, without risk of transfusionrelated infections, and easy to collect blood. However, for some special patients, such as infants, elderly, severely burned patients who are difficult for blood collection, patients with low platelet count, and cord blood should be produced under the standard norms and regulations on the preparation of blood components for topical use.…”

Section: Source Of Platelet For Pgmentioning

confidence: 99%

“…74 CBPG with higher GFs content is prepared for topical application and reported to improve tissue regeneration. 59,[73][74][75]87 There is few researches aimed at comparing the clinical efficacy of CBPG with traditional PG preparations obtained from autologous/allogeneic adult blood donors. Compared with the use of autologous/allogeneic blood platelet gel (ABPG), the number of patients has been treated with CPBG was limited.…”

Section: Source Of Platelet For Pgmentioning

confidence: 99%

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Current applications of platelet gels in wound healing—A review

Wang

Yang

Zhao

et al. 2021

Wound Repair Regeneration

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Human platelets play important roles in several physiologic and pathologic processes.Platelet concentrates are activated with thrombin or calcium, resulting in a viscous coagulum (platelet gel [PG]), composed of 95% platelets at least. PG is increasingly used for the treatment of a variety of soft and hard tissue defects, most notably in the management of chronic non-healing wounds. During wound healing, platelets not only play a critical role in primary hemostasis and thrombosis, but also release growth factors and cytokines to promote tissue regeneration, enhance collagen synthesis, and trigger an immune response. This review addresses a variety of aspects relevant to the functions of well-known platelet growth factors, animal and clinical studies of PG in the last decade, and different sources of platelets for PG. PG is used for nonhealing chronic wounds, such as oral ulcerations related to epidermolysis bullosa and chronic graft-versus-host disease, for those, the traditional treatment effect is poor.PG maybe provide a new therapeutic direction for these diseases. Nevertheless, some uncertainty is present, the number of clinical studies is not enough. Hence, randomized controlled trials are still required to study the potential of the use of PG in the near future. K E Y W O R D Splatelet gel, platelet growth factor, platelet-rich plasma, wound healing | INTRODUCTIONOver the past three decades, extensive cellular and molecular details were elucidated regarding the regulation of cutaneous wound healing. 1,2 Although platelets are fundamental components of the hemostatic response to vessel damage. It is worth noting that platelet rich plasma (PRP) gel/platelet gel (PG) is increasingly used for the treatment of a variety of soft and hard tissue defects, most notably in the management of chronic non-healing wounds and in accelerating bone formation. [3][4][5][6][7][8] Wound healing is a very intricate process involving the complex interplay of numerous humoral factors and cells. PG as a new application was proposed during the last 30 years, to favour wound healing through the growth factors (GFs) released by platelets during clotting. Platelet concentrates are activated with thrombin or calcium, which induces the release of GFs and also fibrin generation, resulting in a viscous coagulum (PG), composed of 95% platelets at least. 9 A wound is defined as damage or disruption to the normal anatomical structure and function, and it may cause damage in other structures such as tendons, muscles, vessels, nerves, parenchymal

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Section: Source Of Platelet For Pgmentioning

confidence: 99%

Section: Source Of Platelet For Pgmentioning

confidence: 99%

Current applications of platelet gels in wound healing—A review

Wang

Yang

Zhao

et al. 2021

Wound Repair Regeneration

View full text Add to dashboard Cite

show abstract

“…Pougatsch [17] made a pilot study using acceptable methods of cleansing combined with salt-based spray then gauze sponges soaked with the spray to dress the ulcer and then covered with dry foam or gauze and wrap with ACE to bring a wound closure. Volpe et al [18] used three groups for a non-blinded, consecutive series, randomized clinical trial where Group A is managed with standard wound care while Group B is managed with topical application of CBPG consisted of platelet gel application 2 times a week in 4 weeks and then once a week for an additional 4 weeks. The primary outcome resulted to ulcer area reduction.…”

Section: Primary Outcomementioning

confidence: 99%

Best and Effective Practices of Wound Care and Healing Among Patients with Diabetes Mellitus

2019

Endocrinol Diabetes Metab J

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Aim: With the continuing trend in the incidence of diabetic ulcer, current researches from evidence-based practice augment best and effective practices on wound care and healing among patients suffering from diabetes mellitus. Methods: This study utilized a systematic review of literatures in light of wound care through Pub Med database with the key words "Diabetes Mellitus," "wound practices," "wound healing," and "systematic review." The searched literatures were of case reports, interventional studies, and review papers whose main texts were in English. Results: There were 7,988 published articles yielded from the keywords used and 16 were included in this study. The practiced management and techniques in these literatures focused on comfortable and cost efficient means of wound care and healing with the involvement of group participation than individual plan of care. Conclusions: There are meager evidences for vigorous wound and healing options that needs further studies in resolving wound issues among patients with Diabetes Mellitus. This systematic review establishes the insufficiency of high level of evidence based studies on wound healing in DM patients and brings a track for continuity of rigid studies concerning this topic.

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“…Hence, an increasing number of topical treatments have been developed, particularly involving debridement methods including surgical, biological, and dressing debridement, and have been widely applied for the treatment of diabetic patients in the clinical setting (26). Debridement eliminates necrotic tissue, decreases chronic inflammatory factor levels, increases cytokine secretion, promotes the growth of granulation tissue and reduces the absorption of toxins during necrosis tissue decomposition and degradation (27–29). Therefore, debridement is widely used in the clinical setting to promote wound healing in patients with diabetes (30).…”

Section: Introductionmentioning

confidence: 99%

Low‑frequency ultrasound enhances vascular endothelial growth factor expression, thereby promoting the wound healing in diabetic rats

et al. 2019

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Diabetes is a chronic metabolic disease with a high prevalence worldwide, which typically delays or impairs wound healing, potentially causing death. Low-frequency ultrasound treatment promotes the repair of various injuries and may promote wound healing. The aim of the present study was to determine whether low-frequency ultrasound can accelerate wound healing, as well as investigate its effects on the expression of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in diabetic rats. A total of 45 Wistar rats were intraperitoneally injected with 1% streptozocin following intraperitoneal injection of pentobarbital sodium anesthesia. Subsequently an incision wound was created in the skin of back. The area of the wound was recorded to calculate the rate of wound healing. The expression of VEGF and TGF-β1 was determined via immunohistochemical analysis and their mRNA and protein levels were measured via reverse transcription-quantitative PCR analysis. The results revealed that when compared with the control group, low-frequency ultrasound treatment significantly increased wound healing rate in diabetic rats and markedly increased the mRNA and protein levels of VEGF and TGF-β1. US treatment also reduced the mRNA and protein levels of TNF-α and IL-6. In conclusion, the results of the present study indicated that low-frequency ultrasound promotes the expression of VEGF and TGF-β1, and inhibits the expression of IL-6 and TNF-α, thereby promoting wound healing in diabetic rats.

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Efficacy of cord blood platelet gel application for enhancing diabetic foot ulcer healing after lower limb revascularization

Cited by 31 publications

References 15 publications

Current applications of platelet gels in wound healing—A review

Current applications of platelet gels in wound healing—A review

Best and Effective Practices of Wound Care and Healing Among Patients with Diabetes Mellitus

Low‑frequency ultrasound enhances vascular endothelial growth factor expression, thereby promoting the wound healing in diabetic rats

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