Efficacy of continuous wear PureVision contact lenses for therapeutic use

Arora, Ritu; Jain, Shyama; Monga, Sumit; Narayanan, Raja; Raina, Usha K; Mehta, Dinesh

doi:10.1016/j.clae.2003.09.004

Cited by 65 publications

(39 citation statements)

References 5 publications

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“…4 ) minimizes side effects like foreign body sensation, irritation, and inflammation in the cornea of the eye. Good stability and centration of the lens are important factors in facilitating corneal epithelial healing [56] . Minimal lens loss shows that SCBL adheres well on the cornea and patients tolerated the lens well without any complications.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Evaluation of Succinylated Collagen Bandage Lenses for Ophthalmic Applications

et al. 2008

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Aim: To study whether succinylated collagen bandage lenses (SCBL) prepared from modified bovine collagen (succinylated collagen) can replace other bandage lenses presently employed to treat various corneal conditions like filamentary keratitis, dry eyes, recurrent corneal erosions, foreign body removal and epithelial trauma. Methods: This observational case study included 32 patients (22 female and 10 male): 8 patients for filamentary keratitis (25%), 10 patients for dry eyes (31%), 4 patients for recurrent corneal erosions (13%), 7 patients for foreign body removal (22%) and 3 patients for epithelial trauma (9%). Their eyes were evaluated for biocompatibility, in vivo transparency, patient comfort, corneal fit, best corrected visual acuity (BCVA), tear fluid level and dissolution rate of SCBL. This was carried out over a 24-hour period of time. Results: SCBL exhibited good transparency and remained transparent throughout the period of study (between 0 and 24 h) in the eyes of patients. SCBL did not cause any irritation, discomfort and foreign body sensation in the eye and eyes remained comfortable throughout the experiment. BCVA in the control group of patients was 1.00 (20/20). Mean (±SD) BCVA before inserting SCBL (in decimal equivalent) was 0.31 (20/60) ± 0.18 (range 0.1– 0.66). BCVA (±SD) changed to 0.25 (20/80) ± 0.18 4 h after the application of SCBL and 0.27 (20/70) ± 0.18 24 h after the application of SCBL, with a safety index of 1.20. The mean (±SD) tear fluid level before application of SCBL was 11.9 ± 5.39 h (range 3–24 mm) and changed to 13.9 ± 5.68 h (range 5–28 mm) after 4 h of application of SCBL and 15.9 ± 5.72 h (range 7–30 mm) after 24 h with a safety index of 13 mm. The mean (±SD) dissolution rate of SCBL in the control group of patients was 17.8 ± 8.65 h (range 10–24 h) and the mean (±SD) dissolution rate in the experimental group was 22.2 ± 9.29 h (range 10–24 h). We report the use of SCBL in various corneal conditions. Conclusion: The present study showed that SCBL has complete corneal fit and good comfort in human eyes. Transparency was maintained for a longer period along with fair visual acuity and improvement in tear fluid levels. The disadvantages of other bandage lenses presently used to treat various corneal conditions could be overcome by the use of SCBL lenses.

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Section: Discussionmentioning

confidence: 99%

“…The thickness of the SCBL is around 0.05-0.1 mm, which minimizes discomfort during blinking of eyes, closure of eyelids and eye movement. Oxygen permeability of the lens is an essential requirement to prevent corneal edema and to enhance wound healing in the eye [52,56] . Oxygen permeability of the SCBL is 27-30 !…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Succinylated Collagen Bandage Lenses for Ophthalmic Applications

et al. 2008

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“…However, they observed that many of the studies did not declare a proper randomization process and had a high number of dropouts. The application of a soft therapeutic contact lens has been considered in various studies[16,17,18,19,20,21], among the first being reports from outcomes of treatment of corneal abrasions following excimer laser photorefractive keratectomy [16,21]. Contact lenses have been associated with a greater relief of pain and photophobia as well as vision increase compared to ‘traditional' methods of treatment.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Traumatic Corneal Abrasions: A Three-Arm, Prospective, Randomized Study

et al. 2013

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Purpose: To compare three different treatment modalities for traumatic corneal abrasions. Methods: We conducted a prospective, randomized, masked, three-arm clinical study of patients presenting with superficial corneal foreign bodies. Treatment modalities were: (1) pressure patching with ofloxacin ointment (patch group, PG, n = 18), (2) therapeutic contact lens with ofloxacin eye drops (contact lens group, CLG, n = 20) and (3) ofloxacin ointment alone (ointment group, OG, n = 28). Primary outcome measure was the difference of the mean corneal abrasion area between the three groups at 3 different time points (baseline, day 1 and day 7). Results: A total of 66 patients were included in the study over a period of 2 years. Mean initial corneal abrasion area was 3.6 ± 3.4 mm² in the PG, 4.2 ± 4.0 mm² in the CLG and 3.7 ± 3.1 mm² in the OG (p = 0.875). Differences in corneal abrasion area at any time point were not statistically significant (abrasion area decrease from presentation to day 1 was 3.4 ± 3.3 mm² in the PG, 4.1 ± 4.0 mm² in the CLG and 3.5 ± 3.1 mm² in the OG, p = 0.789). The epithelium was healed in all patients at day 7. Conclusions: Treating traumatic corneal abrasions by pressure patching, a bandage contact lens or ointment alone was equal in reducing the abrasion area or reducing pain. According to our results the treatment of choice for traumatic abrasions may be adapted to the needs and preferences of the patient.

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“…Whereas the primary cosmetic role of contact lenses is vision correction, therapeutic indications for use of bandage lenses include pain relief, corneal protection and enhancement of corneal wound healing [10][11][12]. Bandage contact lenses play a key role in corneal transplant surgery, and are routinely used in penetrating keratoplasties, pterygia, total superficial keratectomies and corneal ring segment procedures [13,14].…”

Section: Introductionmentioning

confidence: 99%

Structural design of contact lens-based drug delivery systems; in vitro and in vivo studies of ocular triggering mechanisms

Mahomed

Wolffsohn

Tighe

2016

Contact Lens and Anterior Eye

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This study identifies and investigates the potential use of in-eye trigger mechanisms to supplement the widely available information on release of ophthalmic drugs from contact lenses under passive release conditions. Ophthalmic dyes and surrogates have been successfully employed to investigate how these factors can be drawn together to make a successful system. The storage of a drug-containing lens in a pH lower than that of the ocular environment can be used to establish an equilibrium that favours retention of the drug in the lens prior to ocular insertion. Although release under passive conditions does not result in complete dye elution, the use of mechanical agitation techniques which mimic the eyelid blink action in conjunction with ocular tear chemistry promotes further release. In this way differentiation between passive and triggered in vitro release characteristics can be established. Investigation of the role of individual tear proteins revealed significant differences in their ability to alter the equilibrium between matrix-held and eluate-held dye or drug. These individual experiments were then investigated in vivo using ophthalmic dyes. Complete elution was found to be achievable in-eye; this demonstrated the importance of that fraction of the drug retained under passive conditions and the triggering effect of in-eye conditions on the release process. Understanding both the structure-property relationship between drug and material and in-eye trigger mechanisms, using ophthalmic dyes as a surrogate, provides the basis of knowledge necessary to design ocular drug delivery vehicles for in-eye release in a controllable manner.

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Efficacy of continuous wear PureVision contact lenses for therapeutic use

Cited by 65 publications

References 5 publications

Clinical Evaluation of Succinylated Collagen Bandage Lenses for Ophthalmic Applications

Clinical Evaluation of Succinylated Collagen Bandage Lenses for Ophthalmic Applications

Treatment of Traumatic Corneal Abrasions: A Three-Arm, Prospective, Randomized Study

Structural design of contact lens-based drug delivery systems; in vitro and in vivo studies of ocular triggering mechanisms

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