Treatment of Traumatic Corneal Abrasions: A Three-Arm, Prospective, Randomized Study

Abstract

Purpose: To compare three different treatment modalities for traumatic corneal abrasions. Methods: We conducted a prospective, randomized, masked, three-arm clinical study of patients presenting with superficial corneal foreign bodies. Treatment modalities were: (1) pressure patching with ofloxacin ointment (patch group, PG, n = 18), (2) therapeutic contact lens with ofloxacin eye drops (contact lens group, CLG, n = 20) and (3) ofloxacin ointment alone (ointment group, OG, n = 28). Primary outcome measure was the difference of the mean corneal abrasion area between the three groups at 3 different time points (baseline, day 1 and day 7). Results: A total of 66 patients were included in the study over a period of 2 years. Mean initial corneal abrasion area was 3.6 ± 3.4 mm² in the PG, 4.2 ± 4.0 mm² in the CLG and 3.7 ± 3.1 mm² in the OG (p = 0.875). Differences in corneal abrasion area at any time point were not statistically significant (abrasion area decrease from presentation to day 1 was 3.4 ± 3.3 mm² in the PG, 4.1 ± 4.0 mm² in the CLG and 3.5 ± 3.1 mm² in the OG, p = 0.789). The epithelium was healed in all patients at day 7. Conclusions: Treating traumatic corneal abrasions by pressure patching, a bandage contact lens or ointment alone was equal in reducing the abrasion area or reducing pain. According to our results the treatment of choice for traumatic abrasions may be adapted to the needs and preferences of the patient.

Effect of Topically Administered Chitosan-N-acetylcysteine on Corneal Wound Healing in a Rabbit Model

“…Classically, the measurement of lesion size is performed using fluorescein staining of the corneal defect followed by the measurement of wound size by means of slit lamp examination or photography [26–29]. This approach is however limited by the need for a dye to perform corneal staining, which in turn may influence wound healing.…”

Epidemiologic Evaluation and Clinical Aspects of Superficial Corneal Foreign Body Injuries at a Tertiary Referral Center in İstanbul

“…Studies did not suggest a routine eye patch for corneal abrasions, because it does not have any effect on healing time and pain (10). It has also been indicated that smaller abrasions, as in CFB trauma, could be treated only with antibiotic ointments (11).…”

Diffuse Corneal Abrasion After Ocular Exposure to Laundry Detergent Pod

“…12,14 CONCLUSIONS Although ocular injury from laundry detergent pod contents is an acknowledged danger in the pediatric population, the significance and extent of injury, as well as appropriate management, is not well documented. Tetracycline antibiotics, such as tetracycline and doxycycline, as well as fluoroquinolones, are reported in case reports.…”