Efficacy of complete decongestive therapy and manual lymphatic drainage on treatment-related lymphedema in breast cancer

Koul, Rashmi; Dufan, Tarek A.; Russell, Catherine; Guenther, W.; Nugent, Zoan; Sun, Xuyan; Cooke, Andrew

doi:10.1016/j.ijrobp.2006.09.024

Cited by 82 publications

(76 citation statements)

References 14 publications

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“…Patients are required to wear tight, uncomfortable garments for the rest of their lives and risk worsening of the condition with repeated infections. 5 The development of effective treatment options for lymphedema has been hampered by the fact that the etiology of this disorder remains poorly understood. Thus, although it is clear that the initiating event in postsurgical lymphedema is injury to the lymphatic channels, it is unknown why some patients develop this complication while others who are identically treated do not.…”

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confidence: 99%

Blockade of Transforming Growth Factor-β1 Accelerates Lymphatic Regeneration during Wound Repair

Avraham

Daluvoy

Zampell

et al. 2010

The American Journal of Pathology

162

224

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Lymphedema is a complication of cancer treatment occurring in approximately 50% of patients who undergo lymph node resection. Despite its prevalence, the etiology of this disorder remains unknown. In this study, we determined the effect of soft tissue fibrosis on lymphatic function and the role of transforming growth factor (TGF)-␤1 in the regulation of this response. We determined TGF-␤ expression patterns in matched biopsy specimens collected from lymphedematous and normal limbs of patients with secondary lymphedema. To determine the role of TGF-␤ in regulating tissue fibrosis, we used a mouse model of lymphedema and inhibited TGF-␤ function either systemically with a monoclonal antibody or locally by using a Lymphedema is a dreaded complication of cancer management that results from the disruption of lymphatic channels. It is estimated that 3 to 5 million Americans have chronic lymphedema and suffer from chronic swelling, recurrent infections, pain, impaired function, and decreased quality of life.1-4 Remarkably, despite the prevalence and morbidity of lymphedema, there is currently no known cure and treatment remains primarily symptomatic in nature with the goal of preventing disease progression. Patients are required to wear tight, uncomfortable garments for the rest of their lives and risk worsening of the condition with repeated infections. 5The development of effective treatment options for lymphedema has been hampered by the fact that the etiology of this disorder remains poorly understood. Thus, although it is clear that the initiating event in postsurgical lymphedema is injury to the lymphatic channels, it is unknown why some patients develop this complication while others who are identically treated do not. In addition, it remains unknown why lymphedema develops in some patients after seemingly trivial lymphatic injury. None of the authors have any commercial associations or financial relationships that would create a conflict of interest with the work presented in this article.Address reprint requests to Babak J.

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mentioning

confidence: 99%

Blockade of Transforming Growth Factor-β1 Accelerates Lymphatic Regeneration during Wound Repair

Avraham

Daluvoy

Zampell

et al. 2010

The American Journal of Pathology

162

224

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“…The main objective of the lymphedema treatment is to reduce volume, restore function, and improve physical appearance of the affected limb 16 . Although the limb function was not evaluated, this study showed that in the studied sample there was a reduction of the lymphedema, after using the proposed protocol.…”

Section: Discussionmentioning

confidence: 99%

Linfedema pós-mastectomia: um protocolo de tratamento

et al. 2013

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| Lymphedema is still considered as one of the main sequela resulting from surgical treatment of breast cancer. The aim of this study was to evaluate the efficacy of a protocol that included use of a high-voltage electrical stimulation (HVES) associated with therapeutic exercises, self-massage, and self-care for the treatment of lymphedema of the upper limbs in women who underwent surgery for breast cancer treatment. This study included 17 volunteers (60.9_ +11.72 years of age) submitted to unilateral mastectomy, with lymphedema of the upper limb, ipsilateral to surgery. The treatment consisted of application of 14 HVES, to the patients, twice a week, supplemented by guidance on self-care, self-massage, and physical exercises. The evolution of this treatment was assessed by perimetry, calculation of the volume difference (VD) between the limbs, and calculation of the volume increase percentage (VIP) of the affected limb compared to the contralateral limb. Data were analyzed using the statistical method for paired T and dependent variables, which showed a significant reduction of 14.13% (p=0.0067) in VIP and 13.8% (p=0.0089) in VD, as well as perimetry at the following three points: 7 cm above the elbow (p=0.0138), 7 cm below the elbow (p=0.0282), and at the wrist (p=0.0476). It was concluded that the use of HVES associated with the exercises and guidance on self-care and self-massage was effective to reduce the lymphedema in the evaluated group. RESUMO | O linfedema ainda é uma das principais sequelas decorrentes do tratamento cirúrgico do cânc-er de mama. O objetivo do estudo foi avaliar a eficácia de um protocolo que inclui a utilização da estimulação elétrica de alta voltagem (EEAV) associada a exercícios terapêuticos, automassagem e autocuidados no tratamento do linfedema de membros superiores em mulheres submetidas a cirurgia para tratamento do câncer de mama. Participaram do estudo 17 voluntárias (60,9_ +11,72 anos) submetidas à mastectomia unilateral, portadoras de linfedema de membro superior, homolateral à cirurgia. O tratamento constituiu-se de 14 aplicações da EEAV, duas vezes por semana, complementadas por orientações quanto ao autocuidado, automassagem e exercícios físicos. A evolução do tratamento foi avaliada por perimetria, cálculo da diferença de volume (DV) entre os membros, e percentual de aumento do volume (PAV) do membro afetado em relação ao contralateral. Os dados foram analisados por meio do método estatís-tico T pareado para variáveis dependentes e revelaram redução significativa de 14,13% (p=0,0067) do PAV e de 13,8% (p=0,0089) da DV, bem como da perimetria em três pontos: sete centímetros acima do cotovelo (p=0,0138), sete centímetros abaixo do cotovelo (p=0,0282) e no punho (p=0,0476). Pôde-se concluir que a utilização da estimulação elétrica de alta voltagem associada a exercícios e orientações foi eficaz na redução do linfedema do grupo avaliado. Keywords | breast neoplasms; lymphedema; rehabilitationDescritores | neoplasias da mama; linfedema; reabilitação. Barros et al. ...

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“…In this case, annual lymphatic drainage was used in an attempt to accelerate the resolution of the process. Manual lymphatic drainage can be used to reduce the lymphedema associated with neoplasias 15,17 . There were no reports related to its use for the clinical picture described here.…”

Section: Discussionmentioning

confidence: 99%

Enfisema subcutâneo causado por sonda nasofaríngea para administração de oxigênio suplementar: relato de caso

Gasparini¹,

Ferreira

Rangel

2010

Rev. Bras. Anestesiol.

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Summary: Gasparini JR, Ferreira LC, Rangel VHM -Subcutaneous Emphysema Induced by Supplementary Oxygen Delivery Nasopharyngeal Cannula. Case report. Background and objectives:The development of subcutaneous emphysema involving face, neck, and thorax has been well-documented in cases of odontologic procedures, head and/or neck surgery, and craniofacial trauma. Its development without known damage to the mucosa is rare. This report describes the case of a patient who developed emphysema without an obvious lesion.

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Efficacy of complete decongestive therapy and manual lymphatic drainage on treatment-related lymphedema in breast cancer

Cited by 82 publications

References 14 publications

Blockade of Transforming Growth Factor-β1 Accelerates Lymphatic Regeneration during Wound Repair

Blockade of Transforming Growth Factor-β1 Accelerates Lymphatic Regeneration during Wound Repair

Linfedema pós-mastectomia: um protocolo de tratamento

Enfisema subcutâneo causado por sonda nasofaríngea para administração de oxigênio suplementar: relato de caso

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