Efficacy of combined vaccination against Mycoplasma hyopneumoniae and porcine reproductive and respiratory syndrome virus in dually infected pigs

Bourry, Olivier; Fablet, C.; Simon, Gaëlle; Marois-Créhan, Corinne

doi:10.1016/j.vetmic.2015.09.015

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…A combined vaccine associating two major pathogens involved in Porcine respiratory disease complex are Mycoplasma hyopneumoniae (Mhp) and porcine reproductive and respiratory syndrome virus (PRRSV). In their research, Bourry et al, reveal that combining Mhp and PRRSV MLV1 vaccines did not induce any negative interference which would reduce the efficacy of each individual vaccine and that combined vaccination is more efficient than the single ones for controlling a dual Mhp/EU-PRRSV infection in pigs [57]. Another swine combined vaccine, this new ready to use combination vaccine is shown to be safe and efficacious against Porcine CircoVirus type 2 and Mhp single and combined infections [58].…”

Section: Discussionmentioning

confidence: 97%

Development and Evaluation of a Combined Contagious Bovine Pleuropneumonia (CBPP) and Lumpy Skin Disease (LSD) Live Vaccine

Safini

Elmejdoub

Bamouh

et al. 2022

Viruses

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Mycoplasma mycoides subsp. mycoides (Mmm) is the causative agent of contagious bovine pleuropneumonia (CBPP). Lumpy skin disease (LSD) is a viral disease of cattle caused by lumpy skin disease virus (LSDV). LSD and CBPP are both transboundary diseases spreading in the same areas of Africa and Asia. A combination vaccine to control CBPP and LSD offers significant value to small-scale livestock keepers as a single administration. Access to a bivalent vaccine may improve vaccination rates for both pathogens. In the present study, we evaluated the LSDV/CBPP live combined vaccine by testing the generation of virus neutralizing antibodies, immunogenicity, and safety on target species. In-vitro assessment of the Mycoplasma effect on LSDV growth in cell culture was evaluated by infectious virus titration and qPCR during 3 serial passages, whereas in-vivo interference was assessed through the antibody response to vaccination. This combined Mmm/LSDV vaccine could be used to protect cattle against both diseases with a single vaccination in the endemic countries. There were no adverse reactions detected in this study and inoculated cattle produced high levels of specific antibodies starting from day 7 post-vaccination, suggesting that this combination vaccine is both safe and effective.

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Section: Discussionmentioning

confidence: 97%

Development and Evaluation of a Combined Contagious Bovine Pleuropneumonia (CBPP) and Lumpy Skin Disease (LSD) Live Vaccine

Safini

Elmejdoub

Bamouh

et al. 2022

Viruses

View full text Add to dashboard Cite

show abstract

“…Other studies also implicated that a single-dose vaccination against Mhp alone decreased the levels of PRRSV viremia and PRRSV-associated pulmonary lesions, whereas single-dose vaccination against PRRSV alone did not decrease nasal shedding of Mhp and Mhp-associated pulmonary lesions in the co-infected pigs (S. J. . Combining vaccines with Mhp and PRRSV did not induce negative interaction which would reduce the efficacy of each individual vaccine (Bourry, Fablet, Simon, & Marois-Crehan, 2015). These results indicated that, the combined vaccination is more efficient than single ones, consequently, further research should focus on the developing of combined vaccine, which can improve the convenient and efficient pig production simultaneously.…”

Section: Porcine Reproductive and Respiratory Syndrome Virusmentioning

confidence: 88%

Co-Infection of Mycoplasma hyopneumoniae and other swine pathogens

Wang

Shu

et al. 2020

Preprint

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Mycoplasma hyopneumoniae (M. hyopneumoniae, Mhp) is an etiological agent that causes mycoplasma pneumonia of swine (MPS), this is a chronic respiratory disease present in every major swine-producing country worldwide. It is well elucidated, Mhp infections may downregulate the host immune system and enhance the infection and replication of other pathogens. However, the mechanisms of interaction between Mhp and other pathogens is still missing. Though, additional studies have reported that several cofactors such as bacteria, vaccination failure, stress or crowing and other swine viruses in combination with Mhp, lead to MPS. Aside these cofactors, the co-infection of Mhp with other viruses, such as Porcine Circovirus, Porcine Reproductive and Respiratory Syndrome Virus, Swine Influenza Virus, Pseudorabies Virus, and other bacteria, such as Pasteurella multocida, Actinobacillus pleuropneumoniae have been widely studied for many years. In this review, we summarized the co-infection of Mhp with other swine pathogens based our studies made, the co-infection with other viruses and bacteria, revealed the interaction mechanism of different pathogens with Mhp in the host Co-Infection of Mycoplasma hyopneumoniae and otherswine pathogens

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“…PRDC is one of the main causes of economic losses for swine producers worldwide. This complex is due to a combination of different pathogens and their interactions, Mhp and PRRSV are the two main pathogens involved in PRDC (19). Mhp and PRRSV are often infected simultaneously, infection with Mhp could potentiate and prolong PRRSV-induced pneumonia clinically (5).…”

Section: Discussionmentioning

confidence: 99%

A Candidate Multi-epitope Vaccine Against Porcine Reproductive and Respiratory Syndrome Virus and Mycoplasma Hyopneumoniae

Gao¹,

Chen²,

Pan³

et al. 2021

Preprint

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Background: Porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae (M. hyopneumoniae, Mhp) are two of the most common pathogens involved in the porcine respiratory disease complex (PRDC) which results in significant worldwide economic losses. Vaccination is reported to be the most effective approach to prevent the disease. Since PRRSV and Mhp co-infections are very common, an efficient dual vaccine against PRRSV and Mhp co-infections is required for the global swine industry. Compare with the traditional vaccine, the multi-epitope vaccines have several advantages, such as comparatively easy production and construction, chemical stability, and lack of infectious potential.Results: In this study, to develop a safe and effective vaccine, B cell epitopes and T cell epitopes of PRRSV-GP5, PRRSV-M, Mhp-P46 and Mhp-P65 protein had been screened to construct a recombinant epitope protein rEP-PM which has good hydrophilicity, strong antigenicity and high surface accessibility, and each epitope is independent and complete. After immunization in mice, rEP-PM could induce the production of high levels of antibodies and effective cellular immune response.Conclusions: Our results showed that the rEP-PM protein could be potential candidate to develop into a safe and effective multi-epitope peptide combined vaccine used in the control of PRRSV and Mhp infection.

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Efficacy of combined vaccination against Mycoplasma hyopneumoniae and porcine reproductive and respiratory syndrome virus in dually infected pigs

Cited by 9 publications

References 15 publications

Development and Evaluation of a Combined Contagious Bovine Pleuropneumonia (CBPP) and Lumpy Skin Disease (LSD) Live Vaccine

Development and Evaluation of a Combined Contagious Bovine Pleuropneumonia (CBPP) and Lumpy Skin Disease (LSD) Live Vaccine

Co-Infection of Mycoplasma hyopneumoniae and other swine pathogens

A Candidate Multi-epitope Vaccine Against Porcine Reproductive and Respiratory Syndrome Virus and Mycoplasma Hyopneumoniae

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