Efficacy of clindamycin in reducing pain following tonsillectomy in adults: a double-blind, randomised trial

Baradaranfar, Mohammad Hossein; Zand, Vahid; Dadgarnia, Mohammad Hossein; Atighechi, Saeid

doi:10.1017/s0022215113002351

Cited by 7 publications

(4 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eight eligible studies [126][127][128][129][130][131][132][133] reported inconclusive pain outcomes with the use of antibiotics. In studies reporting an analgesic effect, two tested antibiotic mouth wash.…”

Section: Other Therapiesmentioning

confidence: 99%

PROSPECT guideline for tonsillectomy: systematic review and procedure‐specific postoperative pain management recommendations

et al. 2020

View full text Add to dashboard Cite

Tonsillectomy is one of the most frequently performed surgical procedures; however, pain management remains challenging. Procedure-specific efficacy as well as specific risks of treatment options should guide selection of pain management protocols based on evidence and should optimise analgesia without harm. The aims of this systematic review were to evaluate the available literature and develop recommendations for optimal pain management after tonsillectomy. A systematic review utilising preferred reporting items for systematic reviews and meta-analysis guidelines with procedure-specific postoperative pain management (PROSPECT) methodology was undertaken. Randomised controlled trials published in the English language up to November 2019 assessing postoperative pain using analgesic, anaesthetic or surgical interventions were identified. Out of the 719 potentially eligible studies identified, 226 randomised controlled trials met the inclusion criteria, excluding the studies examining surgical techniques. Pre-operative and intra-operative interventions that improved postoperative pain were paracetamol; non-steroidal anti-inflammatory drugs; intravenous dexamethasone; ketamine (only assessed in children); gabapentinoids; dexmedetomidine; honey; and acupuncture. Inconsistent evidence was found for local anaesthetic infiltration; antibiotics; and magnesium sulphate. Limited evidence was found for clonidine. The analgesic regimen for tonsillectomy should include paracetamol; non-steroidal anti-inflammatory drugs; and intravenous dexamethasone, with opioids as rescue analgesics. Analgesic adjuncts such as intra-operative and postoperative acupuncture as well as postoperative honey are also recommended. Ketamine (only for children); dexmedetomidine; or gabapentinoids may be considered when some of the first-line analgesics are contra-indicated. Further randomised controlled trials are required to define risk and combination of drugs most effective for postoperative pain relief after tonsillectomy.

show abstract

Section: Other Therapiesmentioning

confidence: 99%

PROSPECT guideline for tonsillectomy: systematic review and procedure‐specific postoperative pain management recommendations

et al. 2020

View full text Add to dashboard Cite

show abstract

“…3 Furthermore, the studies to support topical antibiotics in reducing post-tonsillectomy morbidity are inconsistent and have several biases because of methodological flaws. 53,54 Although some studies show that antibiotics reduce the bacterial count in the post-operative tonsillar fossa, 16,55 a clinical correlation in terms of reduction in morbidity is lacking. Hence, Dhiwakar et al (2012) suggest that post-tonsillectomy complications primarily occur as a result of tissue injury and oedema induced by surgical technique, with minimal or nil additional morbidity conferred by bacterial inflammation.…”

Section: Discussionmentioning

confidence: 99%

Can probiotic gargles reduce post-tonsillectomy morbidity in adult patients? A pilot, triple-blind, randomised, controlled trial and feasibility study

et al. 2022

View full text Add to dashboard Cite

Objective This study aimed to determine the efficacy of probiotic gargles compared with placebo gargles on reducing post-tonsillectomy morbidity in adults. Method This was a triple-blind, randomised, controlled trial and feasibility study. Thirty adults underwent elective tonsillectomy and were randomly assigned to receive either probiotic or placebo gargles for 14 days after surgery. Daily pain scores and requirement of analgesia were measured for 14 days post-operatively. Secondary outcomes assessed probiotic safety and tolerability and the feasibility of the trial. Results The probiotic group experienced less pain at rest on day 2. However, the amount of oxycodone (5 mg) tablets used was greater in the probiotic group compared with placebo. There were no statistically significant differences in the frequency of adverse effects between both groups. This trial was feasible. Conclusion This pilot study suggested that probiotic gargles do not reduce post-tonsillectomy pain or bleeding, highlighting the importance of pilot and feasibility studies in clinical research.

show abstract

“…Local perioperative antibiotic prophylaxis remains an open issue, as some recent studies have confirmed reduced pain and postoperative bleeding in patients following local perioperative administration of clindamycin [37]. However, there is also research questioning this concept [38].…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Perioperative Antibiotic Therapy in Tonsillectomy Patients

Orłowski¹,

Lisowska²,

Misiołek³

et al. 2016

Adv Clin Exp Med

View full text Add to dashboard Cite

Efficacy of clindamycin in reducing pain following tonsillectomy in adults: a double-blind, randomised trial

Abstract: Topical clindamycin was not demonstrated to be more effective than normal saline in the reduction of throat pain following tonsillectomy in adults.

Cited by 7 publications

References 46 publications

PROSPECT guideline for tonsillectomy: systematic review and procedure‐specific postoperative pain management recommendations

PROSPECT guideline for tonsillectomy: systematic review and procedure‐specific postoperative pain management recommendations

Can probiotic gargles reduce post-tonsillectomy morbidity in adult patients? A pilot, triple-blind, randomised, controlled trial and feasibility study

The Efficacy of Perioperative Antibiotic Therapy in Tonsillectomy Patients

Contact Info

Product

Resources

About