Efficacy of Cinnamon as an Adjuvant in Reducing the Glycemic Biomarkers of Type 2 Diabetes Mellitus: A Three-Month, Randomized, Triple-Blind, Placebo-Controlled Clinical Trial

Neto, José Cláudio Garcia Lira; Damasceno, Marta María Coelho; Ciol, Márcia A.; Freitas, Roberto Wagner Júnior Freire de; Araújo, Márcio Flávio Moura de; Teixeira, Carla Regina de Souza; Carvalho, Gerdane Celene Nunes; Lisboa, Kenya Waléria Siqueira Coelho; Marques, Regina Lúcio Lino; Alencar, Ana Maria Parente Garcia; Zanetti, María Lúcia

doi:10.1080/07315724.2021.1878967

Cited by 17 publications

(26 citation statements)

References 25 publications

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“…252 A randomized, placebo-controlled, triple-blind clinical trial was designed to evaluate the effects of cinnamon (3 g d −1 ) for 90 days in people with type 2 diabetes. 253 The cinnamon group exhibited statistically significant reductions in HbA1c and fasting venous glucose compared with the placebo group. 253 Consistent with this, supplementation with cinnamon decreased the HOMA index and FBG in patients with NAFLD.…”

Section: Reviewmentioning

confidence: 90%

“…253 The cinnamon group exhibited statistically significant reductions in HbA1c and fasting venous glucose compared with the placebo group. 253 Consistent with this, supplementation with cinnamon decreased the HOMA index and FBG in patients with NAFLD. 84 Despite this, studies have demonstrated that cinnamon does not contribute to glycaemic control and has no preventive or ameliorating effect on metabolic diseases.…”

Section: Reviewmentioning

confidence: 90%

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Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

et al. 2021

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Section: Reviewmentioning

confidence: 90%

Section: Reviewmentioning

confidence: 90%

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

et al. 2021

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“…A total of 104 abstracts were deemed possibly relevant, and the full-text articles were retrieved. Finally, 15 full-text articles ( Mang et al, 2006 ; Vanschoonbeek et al, 2006 ; Blevins et al, 2007 ; Crawford, 2009 ; Akilen et al, 2010 ; Wainstein et al, 2011 ; Lu et al, 2012 ; Vafa et al, 2012 ; Hasanzade et al, 2013 ; Azimi et al, 2014 ; Mirfeizi et al, 2016 ; Talaei et al, 2017 ; Zare et al, 2019 ; Mirmiranpour et al, 2020 ; Lira Neto et al, 2021 ) were included, which encompassed the use of cinnamon powder or aqueous cinnamon extracts. A total of 1,020 patients were included in these 15 randomized controlled trials, with follow-up ranging from 40 days to 4 months.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of cinnamon supplementation on glycolipid metabolism in T2DM diabetes: A meta-analysis and systematic review

Zhou

Lei

et al. 2022

Front. Physiol.

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Background: Cinnamon is a spice used in cooking and in large quantities as a medical complement with hypoglycemic and lipid-lowering properties. The potential pharmacological mechanisms underlying cinnamon’s anti-diabetic properties and its active ingredients have not been adequately determined. The current meta-analysis aims to systematically review the potential pharmacological mechanisms underlying the hypoglycemic and hypolipidemic efficacy of cinnamon administration and summarize clinical recommendations of cinnamon and its active ingredients.Method: Relevant randomized clinical trials (RCTs) were identified through a literature search that spanned the years January 2005 to April 2022. Retrieve electronic databases including Web of Science, PubMed, Embase, Medline, and the Cochrane Library. To obtain standardized mean differences (SMDs), continuous outcomes were pooled and 95 percent confidence intervals (CIs) were provided. Categorical outcomes were aggregated to calculate relative risks (RRs) and were accompanied by 95% CIs. Heterogeneity was measured using the Cochrane Q-test and I2 statistics, with a p < 0.05 considered as substantial heterogeneity. If I2 was less than 50%, a fixed effect model was employed; otherwise, a random effect model was used. Subgroup analyses and sensitivity analyses were performed to identify the origins of heterogeneity. Publication bias was retrieved by means of a funnel-plot analysis and Egger’s test. The data were analyzed using revman (V.5.3) and stata (V.15) software packages.Results: These 16 RCTs included a total of 1,020 patients who were followed for a duration ranging from 40 days to 4 months. According to the current meta-analysis results, glycolipid levels in diabetic individuals who received cinnamon were significantly improved as compared to those who got placebo (All p < 0.05). An adverse effect was only detected in one patient.Conclusion: These findings imply that cinnamon has a significant influence on lipid and glucose metabolism regulation. An even more pronounced effect was observed in patients with HbA1c of 8%. The results of this study suggested that cinnamon may be utilized as hypoglycemic and lipid-lowering supplement in clinical settings with a guaranteed safety profile.Systematic Review Registration: [PROSPERO], identifier [CRD42022322735].

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“…T A B L E 1 Characteristics of included studies in meta-analysis. (Akilen et al, 2010;Azimi et al, 2014;Davari et al, 2020;Hasanzade et al, 2013;Hendre et al, 2019;Hosseini et al, 2014;Khadem et al, 2011;Khan et al, 2003;Lira Neto et al, 2022;Lu et al, 2012;Mang et al, 2006;Mirfeizi et al, 2016a;Mirmiran et al, 2019;Sengsuk et al, 2016;Soni & Bhatnagar, 2009;Talaei et al, 2017;Tangvarasittichai et al, 2015;Vafa et al, 2012;Vanschoonbeek et al, 2006;Wainstein et al, 2011;Zahedifar et al, 2018;Zahmatkesh et al, 2012;Zare et al, 2019) 2b). Therefore, trim and fill methods were performed with 30 effect size (four imputed trials) and the findings were still significant (SMD: À1.82; 95% CI: À2.39, À1.25, p < 0.05).…”

Section: Risk Of Bias Assessment and Quality Of Evidencementioning

confidence: 99%

The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes mellitus: An updated systematic review and dose‐response meta‐analysis of randomized controlled trials

Moridpour,

Kavyani,

Khosravi

et al. 2023

Phytotherapy Research

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Although many randomized controlled trials (RCTs) have revealed the benefits of cinnamon on type 2 diabetes mellitus (T2DM), the effects of cinnamon supplementation on glycemic control in patients with T2DM are inconclusive. Therefore, the aim of this meta‐analysis of RCTs was to assess the effects of cinnamon supplementation in managing glycemic control in patients with T2DM. Scientific international databases including Scopus, Web of Sciences, PubMed, Embase, and the Cochrane Library were searched till December 2022. For net changes in glycemic control, standard mean differences (SMDs) were calculated using random‐effects models. Findings from 24 RCTs revealed that cinnamon supplementation had a statistically significant reduction in fasting blood sugar (SMD: −1.32; 95% CI: −1.77, −0.87, p < 0.001), Homeostatic Model Assessment for Insulin Resistance (SMD: ‐1.32; 95% CI: −1.77, −0.87, p < 0.001), and hemoglobin A1C (SMD: −0.67; 95% CI: −1.18, −0.15, p = 0.011) compared with the control group in patients with T2DM. Additionally, cinnamon did not change the serum levels of insulin (SMD: −0.17; 95% CI: −0.34, 0.01, p = 0.058) significantly. Our analysis indicated that glycemic control indicators are significantly decreased by cinnamon supplementation. Together, these findings support the notion that cinnamon supplementation might have clinical potential as an adjunct therapy for managing T2DM.

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Efficacy of Cinnamon as an Adjuvant in Reducing the Glycemic Biomarkers of Type 2 Diabetes Mellitus: A Three-Month, Randomized, Triple-Blind, Placebo-Controlled Clinical Trial

Cited by 17 publications

References 25 publications

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

Efficacy of cinnamon supplementation on glycolipid metabolism in T2DM diabetes: A meta-analysis and systematic review

The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes mellitus: An updated systematic review and dose‐response meta‐analysis of randomized controlled trials

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