Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

Shang, Chang; Lin, Hongchen; Fang, Xuqin; Wang, Yuling; Jiang, Zhilin; Qu, Yi; Xiang, Ming; Shen, Zihuan; Xin, Laiyun; Lu, Yingdong; Gao, Jialiang; Cui, Xiangning

doi:10.1039/d1fo01935j

Cited by 40 publications

(29 citation statements)

References 253 publications

(293 reference statements)

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“…It also stimulates the growth of beneficial bacteria Akkermansia, Bacteroides, Clostridium III, Psychrobacter, and Intestinimonas, and inhibits the growth of Ruminococcus and Escherichia-Shigella [151]. Cinnamon has also been found to lower blood glucose levels and prevents insulin resistance [152].…”

Section: Herbs and Spicesmentioning

confidence: 99%

The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes

et al. 2022

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Type 1 diabetes mellitus (T1DM) is a disease marked by oxidative stress, chronic inflammation, and the presence of autoantibodies. The gut microbiota has been shown to be involved in the alleviation of oxidative stress and inflammation as well as strengthening immunity, thus its’ possible involvement in the pathogenesis of T1DM has been highlighted. The goal of the present study is to analyze information on the relationship between the structure of the intestinal microbiome and the occurrence of T1DM. The modification of the intestinal microbiota can increase the proportion of SCFA-producing bacteria, which could in turn be effective in the prevention and/or treatment of T1DM. The increased daily intake of soluble and non-soluble fibers, as well as the inclusion of pro-biotics, prebiotics, herbs, spices, and teas that are sources of phytobiotics, in the diet, could be important in improving the composition and activity of the microbiota and thus in the prevention of metabolic disorders. Understanding how the microbiota interacts with immune cells to create immune tolerance could enable the development of new therapeutic strategies for T1DM and improve the quality of life of people with T1DM.

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Section: Herbs and Spicesmentioning

confidence: 99%

The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes

et al. 2022

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“…Evidently, appropriate weight loss, exercise training, and whole-food plant-based diets also have an important potential in this regard. Ample intakes of magnesium and zinc, and nutraceuticals such as chromium picolinate and cinnamon extract, may also be beneficial [ 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 ].…”

Section: Summing Upmentioning

confidence: 99%

Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity—Nutraceutical Options

McCarty

DiNicolantonio

2021

Healthcare

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In people with metabolic syndrome, episodic exposure of pancreatic beta cells to elevated levels of both glucose and free fatty acids (FFAs)—or glucolipotoxicity—can induce a loss of glucose-stimulated insulin secretion (GSIS). This in turn can lead to a chronic state of glucolipotoxicity and a sustained loss of GSIS, ushering in type 2 diabetes. Loss of GSIS reflects a decline in beta cell glucokinase (GK) expression associated with decreased nuclear levels of the pancreatic and duodenal homeobox 1 (PDX1) factor that drives its transcription, along with that of Glut2 and insulin. Glucolipotoxicity-induced production of reactive oxygen species (ROS), stemming from both mitochondria and the NOX2 isoform of NADPH oxidase, drives an increase in c-Jun N-terminal kinase (JNK) activity that promotes nuclear export of PDX1, and impairs autocrine insulin signaling; the latter effect decreases PDX1 expression at the transcriptional level and up-regulates beta cell apoptosis. Conversely, the incretin hormone glucagon-like peptide-1 (GLP-1) promotes nuclear import of PDX1 via cAMP signaling. Nutraceuticals that quell an increase in beta cell ROS production, that amplify or mimic autocrine insulin signaling, or that boost GLP-1 production, should help to maintain GSIS and suppress beta cell apoptosis in the face of glucolipotoxicity, postponing or preventing onset of type 2 diabetes. Nutraceuticals with potential in this regard include the following: phycocyanobilin—an inhibitor of NOX2; agents promoting mitophagy and mitochondrial biogenesis, such as ferulic acid, lipoic acid, melatonin, berberine, and astaxanthin; myo-inositol and high-dose biotin, which promote phosphatidylinositol 3-kinase (PI3K)/Akt activation; and prebiotics/probiotics capable of boosting GLP-1 secretion. Complex supplements or functional foods providing a selection of these agents might be useful for diabetes prevention.

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“…The genus Cinnamomum , (known as cinnamon), belonging to lauraceae family, is a tropical tree originally cultivated in East and Middle Asia and Sri Lanka (Shang et al, 2021). Cinnamon is a common spice that has also been found to benefit diabetic patients due to its lowering of blood glucose.…”

Section: Introductionmentioning

confidence: 99%

“…Cinnamon has been used to improve blood circulation and respiration in traditional medicine (Mir Heidar, 2004; Zargari, 1997). In many studies, neuroprotective, lipid‐lowering, anti‐inflammatory, antioxidant, and hypoglycemic effects of cinnamon have been reported, which some of them are closely related to the development of diabetes and CVDs (Kumar et al, 2019; Shang et al, 2021). Cinnamon has also been shown to help with diabetes management in recent research.…”

Section: Introductionmentioning

confidence: 99%

Diabetic cardiomyopathy was attenuated by cinnamon treatment through the inhibition of fibro‐inflammatory response and ventricular hypertrophy in diabetic rats

Farazandeh

Mahmoudabady

Asghari

2022

Journal of Food Biochemistry

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Diabetic cardiomyopathy (DCM) is a chronic complication of diabetes that emphasizes the urgency of developing new drug therapies. With an illustrious history in traditional medicine to improve diabetes, cinnamon has been shown to possess blood lipids lowering effects and antioxidative and anti‐inflammatory properties. However, the extent to which it protects the diabetic heart has yet to be determined. Forty‐eight rats were administered in the study and grouped as: control; diabetic; diabetic rats given 100, 200, or 400 mg/kg cinnamon extract, metformin (300 mg/kg), valsartan (30 mg/kg), or met/val (combination of both drugs), via gavage for six weeks. Fasting blood sugar (FBS) and markers of cardiac injury including creatine kinase‐muscle/brain (CK‐MB), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) were evaluated in blood samples. Malondialdehyde (MDA) levels, the total contents of thiol, superoxide dismutase (SOD), and catalase (CAT) activities were measured. Histopathology study and gene expression measurement of angiotensin II type 1 receptor (AT1), atrial natriuretic peptide (ANP), beta‐myosin heavy chain (β‐MHC), and brain natriuretic peptide (BNP) were done on cardiac tissue. FBS and cardiac enzyme indicators were reduced in all treated groups. A reduction in MDA level and enhancement in thiol content alongside with increase of SOD and CAT activities were observed in extract groups. The decrease of inflammation and fibrosis was obvious in treated groups, notably in the high‐dose extract group. Furthermore, all treated diabetic groups showed a lowering trend in AT1, ANP, β‐MHC, and BNP gene expression. Cinnamon extract, in addition to its hypoglycemic and antioxidant properties, can prevent diabetic heart damage by alleviating cardiac inflammation and fibrosis. Practical applications This study found that cinnamon extract might protect diabetic heart damage by reducing inflammation and fibrosis in cardiac tissue, in addition to lowering blood glucose levels and increasing antioxidant activity. Our data imply that including cinnamon in diabetic participants' diets may help to reduce risk factors of cardiovascular diseases.

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Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

Abstract: Cardiovascular diseases (CVDs) and diabetes are the leading causes of death worldwide, which underlines the urgent necessity to develop new pharmacotherapies.

Cited by 40 publications

References 253 publications

The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes

The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes

Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity—Nutraceutical Options

Diabetic cardiomyopathy was attenuated by cinnamon treatment through the inhibition of fibro‐inflammatory response and ventricular hypertrophy in diabetic rats

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