Efficacy of chlorophyll c2 for seasonal allergic rhinitis: single-center double-blind randomized control trial

Abstract

Chlorophyll c2 extracted from Sargassum horneri improved allergic symptoms in an animal model of allergic rhinitis. In the present study, we explored the efficacy of chlorophyll c2 in patients with seasonal allergic rhinitis. This was a single-center, randomized, double-blind placebo-controlled trial. Sixty-six patients aged 20-43 years, each with a 2-year history of seasonal allergic rhinitis, were randomly assigned to receive either a single daily dose (0.7 mg) of chlorophyll c2 or placebo for 12 weeks. The use of medications including H1-antihistamines and topical nasal steroids was recorded by rescue medication scores (RMSs) noted after 4, 8, and 12 weeks of treatment. Disease-specific quality of life was measured using the Japan Rhinitis Quality of Life Questionnaire (JRQLQ) both before and after 4, 8, and 12 weeks of treatment. The RMS at 8 weeks was significantly better in the chlorophyll c2 than the placebo group (mean RMS difference = -3.09; 95 % confidence interval = -5.96 to -0.22); the mean RMS at 4 weeks was only slightly better in the chlorophyll c2 group. The JRQLQ scores did not differ significantly between the two groups. Chlorophyll c2 would have a potential to be an alternative treatment for allergic rhinitis.

Variation in Lipid Components from 15 Species of Tropical and Temperate Seaweeds

“…Chl b and Chl c are also important chlorophylls found in seaweeds. They are accessory pigments in the antenna system of Chl a [62,63,64,65]. The present study revealed that the variation of these three kinds of chlorophylls was mainly affected by phylum, namely, Ochrophyta, Chlorophyta, and Rhodophyta, but not by sampling location (Table 2).…”

Silkworm dropping extract regulates food allergy symptoms via inhibition of Th2‐related responses in an ovalbumin‐induced food allergy model

“…Furthermore, chlorophyll C2 inhibited IgE-mediated allergic responses in rhinitis mouse model 36 and decreased the rescue medication scores in clinical double-blind trial of seasonal allergic rhinitis. 37 Therefore, we suggest that SD including various types of chlorophyll shows potential as an anti-allergic agent for treatment of allergic disorders like food allergies.…”

Wheatgrass Juice Administration and Immune Measures during Adjuvant Chemotherapy in Colon Cancer Patients: Preliminary Results

“…Hence, the increased concentration of anti-inflammatory cytokines IL-10 found in the WGJ intervention group can be elucidated by the high content of chlorophyll, flavonoids, and superoxide dismutase in wheatgrass [47]. Chlorophyll, which constitutes one of the major components of wheatgrass, may contribute to the treatment of various inflammation-related diseases, such as dengue [48], cholangiocarcinoma [49], allergic rhinitis [50], and acne vulgaris [51].…”