Efficacy of Chlorin e6-Mediated Sono-Photodynamic Therapy on 4T1 Cells

Li, Qing; Wang, Xiaobing; Wang, Pan; Zhang, Kun; Wang, Haiping; Feng, Xiaolan; Liu, Quanhong

doi:10.1089/cbr.2013.1526

Cited by 57 publications

(50 citation statements)

References 29 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…24,36 Compared with UV light, US has a lot of advantages such as low phototoxicity, 37 deep tissue penetration ability, 38 etc. Therefore, in this study, focused US was used as an external stimulus to irradiate MTN@DTX-CD for controlling DTX release and SDT.…”

Section: Resultsmentioning

confidence: 99%

Reactive Oxygen Species-Manipulated Drug Release from a Smart Envelope-Type Mesoporous Titanium Nanovehicle for Tumor Sonodynamic-Chemotherapy

Shi

Chen

Wang

et al. 2015

ACS Appl. Mater. Interfaces

118

View full text Add to dashboard Cite

Despite advances in drug delivery systems (DDSs), the stimuli-responsive controlled release DDSs with high spatial/temporal resolution are still the best choice. Herein, a novel type of envelope-type mesoporous titanium dioxide nanoparticle (MTN) was developed for one-demand drug delivery platform. Docetaxel (DTX) was loaded in the pores of MTN with a high drug loading efficiency (∼26%). Then β-cyclodextrin (β-CD, a bulky gatekeeper) was attached to the outer surface of MTN via a reactive oxygen species (ROS) sensitive linker to block the pores (MTN@DTX-CD). MTN@DTX-CD could entrap the DTX in the pores and allow the rapid release until a focused ultrasound (US) emerged. A large number of ROS were generated by MTN under US radiation, leading to the cleavage of the ROS-sensitive linker; thus, DTX could be released rapidly since the gatekeepers (β-CD) were detached. Besides, the generation of ROS could also be used for tumor-specific sonodynamic therapy (SDT). Studies have shown the feasibility of MTN@DTX-CD for US-triggered DTX release and sonodynamic-chemotherapy. In the in vitro and in vivo studies, by integrating SDT and chemotherapy into one system, MTN@DTX-CD showed excellent antitumor efficacy. More importantly, this novel DDS significantly decreased the side effects of DTX by avoiding the spleen and hematologic toxicity to tumor-bearing mice.

show abstract

Section: Resultsmentioning

confidence: 99%

Reactive Oxygen Species-Manipulated Drug Release from a Smart Envelope-Type Mesoporous Titanium Nanovehicle for Tumor Sonodynamic-Chemotherapy

Shi

Chen

Wang

et al. 2015

ACS Appl. Mater. Interfaces

118

View full text Add to dashboard Cite

show abstract

“…49,55 This approach holds great potential as neither PDT nor ultrasound is inherently dose-limiting treatments, so applying this combination also as an adjuvant to chemo-or radiation therapy may be a very interesting option.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy and Its Role in Combined Modality Anticancer Treatment

Brodin

Guha

Tomé

2014

Technol Cancer Res Treat

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a relatively new modality for anticancer treatment and although the interest has increased greatly in the recent years, it is still far from clinical routine. As PDT consists of administering a nontoxic photosensitizing chemical and subsequently illuminating the tumor with visible light, the treatment is not subject to dose-limiting toxicity, which is the case for established anticancer treatments like radiation therapy or chemotherapy. This makes PDT an attractive adjuvant therapy in a combined modality treatment regimen, as PDT provides an antitumor immune response through its ability to elicit the release of damage-associated molecular patterns and tumor antigens, thus providing an increased antitumor efficacy, potentially without increasing the risk of treatment-related toxicity. There is great interest in the elicited immune response after PDT and the potential of combining PDT with other forms of treatment to provide potent antitumor vaccines. This review summarizes recent studies investigating PDT as part of combined modality treatment, hopefully providing an accessible overview of the current knowledge that may act as a basis for new ideas or systematic evaluations of already promising results.

show abstract

“…Sonodynamic therapy (SDT) is a relatively new therapeutic method in cancer treatment, and it has produced great progress in recent years [11, 12]. SDT is a noninvasive method utilizing the effect of low-intensity ultrasound and a sonosensitizer.…”

Section: Introductionmentioning

confidence: 99%

“…SDT is a noninvasive method utilizing the effect of low-intensity ultrasound and a sonosensitizer. Using this technique, sonosensitizer is activated by irradiation with low-intensity ultrasound of a suitable frequency, generating reactive oxygen species (ROS), such as free radicals and singlet oxygen, to kill target cells [11]. Based on the characteristic of ultrasound, SDT has many advantages over conventional periodontal treatment, such as no drug resistance, noninvasive, easy repeatability, and strong penetrating power [13].…”

Section: Introductionmentioning

confidence: 99%

Low-Intensity Ultrasound Combined with Hematoporphyrin Monomethyl Ether in the Treatment of Experimental Periodontitis in Rats

Zhuang

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

Objectives. This study aims to evaluate the efficacy of hematoporphyrin monomethyl ether- (HMME-) mediated sonodynamic therapy (SDT) on experimental periodontal disease in rats. Methods. Periodontal disease was induced by submerging ligatures at the first maxillary molar subgingival region in forty-eight male SD rats. After 30 days, the ligatures were removed. The rats were randomly allocated into four groups; the experimental SDT group was treated through hypodermic injection of 40 μg/mL HMME and 3 W/cm2 low-intensity ultrasound irradiation (1 MHz, 600 s). Those in control groups received 40 μg/mL HMME alone (control 1 group) or 3 W/cm2 ultrasound irradiation alone (control 2 group) or were subjected to neither HMME nor ultrasound (control 3 group). After 10 days of treatment, all rats were euthanized, the maxilla was obtained for histological examination, and the alveolar bone level was evaluated by histometric analysis. Results. The control groups showed more bone loss (P < 0.05) after 10 days of treatment than the SDT group. There is no significant difference among the control groups (P > 0.05). Conclusions. HMME mediated SDT was an effective therapy of experimental periodontal tissue in rats.

show abstract

Efficacy of Chlorin e6-Mediated Sono-Photodynamic Therapy on 4T1 Cells

Abstract: The findings demonstrated that Ce6-mediated SPDT enhanced the antitumor efficacy on 4T1 cells compared with SDT and PDT alone, a Caspase-dependent apoptosis and loss of MMP, generation of ROS may be involved.

Cited by 57 publications

References 29 publications

Reactive Oxygen Species-Manipulated Drug Release from a Smart Envelope-Type Mesoporous Titanium Nanovehicle for Tumor Sonodynamic-Chemotherapy

Reactive Oxygen Species-Manipulated Drug Release from a Smart Envelope-Type Mesoporous Titanium Nanovehicle for Tumor Sonodynamic-Chemotherapy

Photodynamic Therapy and Its Role in Combined Modality Anticancer Treatment

Low-Intensity Ultrasound Combined with Hematoporphyrin Monomethyl Ether in the Treatment of Experimental Periodontitis in Rats

Contact Info

Product

Resources

About